HuR-HuB autoregulatory network governs inflammatory factors expression.
Overview
Abstract
Short-lived mRNAs harbor AU-rich elements (AREs) in their 3′ untranslated regions (3′UTRs) that are tightly regulated by ARE-binding proteins. While the Hu family stabilizes target mRNAs, our understanding is largely confined to HuR due to its ubiquitous expression. Other Hu members, long considered neuron-specific, remain incompletely characterized in non-neuronal cells. Notably, HuB is markedly upregulated in various tumors and under cellular stress, but the molecular mechanisms and functional significance underlying its upregulation remain elusive. Here, we show that inflammatory stimulation induces cytoplasmic translocation of HuR. HuR binds directly to the 3′UTR of HuB mRNA, thereby enhancing HuB mRNA stability. Upregulated HuB binds to the HuR nucleocytoplasmic shuttling sequence (HNS) through its RNA recognition motif 3 (RRM3) domain, thereby retaining HuR in the cytoplasm. Collectively, HuB and HuR form a heteromeric complex that coordinately regulates the stability of inflammatory factor mRNAs. Our study identifies HuB as a key post-transcriptional regulator of inflammatory genes and highlights the critical role of the HuB-HuR regulatory network in modulating the stability of inflammation-related mRNAs.
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Datasets cited
- geo:GSM741173, at NCBI GEO; found in the text, “HuR upregulates HuB expression at the…”
Data availability
Raw data for blots and source data for graphs can be found in Supplemental File Sets (uncropped gel images and the source data behind the graphs in the paper). All data generated or analyzed during this study are available from the lead contact on reasonable request.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 2, 28 September 2026
- Authors: added Yueshuang Ke (0000-0003-1518-4271); removed Yueshuang Ke
Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 5 keywords, 8 MeSH terms, 3 funders, 52 references.
Cite
This paper
Fu, X., Lu, Y., Kong, L., Qi, Y., Zhong, X., Ba, X., & Ke, Y. (2026). HuR-HuB autoregulatory network governs inflammatory factors expression. The Journal of biological chemistry, 302(7), 113175. https://
BibTeX
@article{fu2026hur,
author = {Fu, Xingyue and Lu, Yuhan and Kong, Leying and Qi, Yijun and Zhong, Xiyue and Ba, Xueqing and Ke, Yueshuang},
title = {{HuR-HuB autoregulatory network governs inflammatory factors expression}},
journal = {The Journal of biological chemistry},
year = {2026},
month = may,
volume = {302},
number = {7},
pages = {113175},
publisher = {American Society for Biochemistry and Molecular Biology},
issn = {0021-9258},
doi = {10.1016/
url = {https://
pmid = {42167574},
pmcid = {PMC13276331}
}
RIS
TY - JOUR
AU - Fu, Xingyue
AU - Lu, Yuhan
AU - Kong, Leying
AU - Qi, Yijun
AU - Zhong, Xiyue
AU - Ba, Xueqing
AU - Ke, Yueshuang
TI - HuR-HuB autoregulatory network governs inflammatory factors expression
T2 - The Journal of biological chemistry
J2 - J Biol Chem
PY - 2026
DA - 2026/
VL - 302
IS - 7
SP - 113175
SN - 0021-9258
PB - American Society for Biochemistry and Molecular Biology
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
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"language": "en",
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