Investigating the prognostics and theranostic cell cycle-related genes of Hinokinin in high-grade glioma: an integrated network pharmacology, bioinformatics, and molecular docking approach.

Overview

Authors: Oukhdouch Anass^1,2, Nadir Youssef³, Salman El mostafa^4,5, Jebhi Khalid⁶, Zinbi Basma², Sellami Souad², Rais Hanane^1,2

Morphoscience Research Laboratory, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco
Anatomic Pathology Department, Biopathology laboratory, Clinical Research Center, University Hospital Mohammed VI, Marrakech, Morocco
Biological Engineering Laboratory, Faculty of Science and Technology, Sultan Moulay Slimane University, Beni Mellal 23000, Morocco
Genetics department, Clinical Research Center, University Hospital Mohammed VI, Marrakech, Morocco
Research Center for Childhood, Health and Sustainable Development, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco
Histology, Embryology and Cytogenetics Laboratory, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco

Institutions: Cadi Ayyad University (Morocco); Centre Hospitalier Universitaire Mohammed VI (Morocco); Université Sultan Moulay Slimane (Morocco)

Journal: Journal, genetic engineering & biotechnology, volume 24, issue 3, article 100724

Dates: received 14 January 2026; accepted 30 May 2026; published online 17 June 2026; in print September 2026

Type: Research article · Language: English

License: CC BY-NC-ND

Identifiers: DOI 10.1016/j.jgeb.2026.100724 · PMID 42749405 · PMCID PMC13311168 · OpenAlex W7165035347

Open access: gold, a free copy (OpenAlex)

Status: data only

Categories: other condition (population), cellular / molecular (subfield)

Methods: Statistics

Keywords: Glioblastoma, Hinokinin, Cell-cycle kinases, Network pharmacology, Molecular docking

Topic: Berberine and alkaloids research (Pharmacology, Medicine), according to OpenAlex

Citations: not cited yet (Europe PMC); 50 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

geo:GPL570, at NCBI GEO; found in the text, “Hub genes validation”
rcsb.org/structure/https:, at PDB; found in the resources table

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 5 keywords, 50 references.

Cite

This paper

Anass, O., Youssef, N., El mostafa, S., Khalid, J., Basma, Z., Souad, S., & Hanane, R. (2026). Investigating the prognostics and theranostic cell cycle-related genes of Hinokinin in high-grade glioma: an integrated network pharmacology, bioinformatics, and molecular docking approach. Journal, genetic engineering & biotechnology, 24(3), 100724. https://doi.org/10.1016/j.jgeb.2026.100724

BibTeX

@article{anass2026investigating, author = {Anass, Oukhdouch and Youssef, Nadir and El mostafa, Salman and Khalid, Jebhi and Basma, Zinbi and Souad, Sellami and Hanane, Rais}, title = {{Investigating the prognostics and theranostic cell cycle-related genes of Hinokinin in high-grade glioma: an integrated network pharmacology, bioinformatics, and molecular docking approach}}, journal = {Journal, genetic engineering \& biotechnology}, year = {2026}, month = jun, volume = {24}, number = {3}, pages = {100724}, publisher = {Academy of Scientific Research and Technology, Egypt}, issn = {1687-157X}, doi = {10.1016/j.jgeb.2026.100724}, url = {https://doi.org/10.1016/j.jgeb.2026.100724}, pmid = {42749405}, pmcid = {PMC13311168} }

RIS

TY - JOUR AU - Anass, Oukhdouch AU - Youssef, Nadir AU - El mostafa, Salman AU - Khalid, Jebhi AU - Basma, Zinbi AU - Souad, Sellami AU - Hanane, Rais TI - Investigating the prognostics and theranostic cell cycle-related genes of Hinokinin in high-grade glioma: an integrated network pharmacology, bioinformatics, and molecular docking approach T2 - Journal, genetic engineering & biotechnology J2 - J Genet Eng Biotechnol PY - 2026 DA - 2026/06/17 VL - 24 IS - 3 SP - 100724 SN - 1687-157X PB - Academy of Scientific Research and Technology, Egypt DO - 10.1016/j.jgeb.2026.100724 UR - https://doi.org/10.1016/j.jgeb.2026.100724 LA - en ER -

CSL-JSON

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