OSCR

Persistent histone H3K27 acetylation contributes to excessive scar formation after spinal cord injury through the regulation of microglial cholesterol accumulation.

Overview

Authors: Qiujiang Qiao1,2,3,4, Qing Gong2,3,4, Ning Li5, Haowei Sun1, Xufang Ru2,3,4, Ning Mu2,3,4, Beike Chen2,3,4, Wenyan Li2,3,4, Tunan Chen2,3,4, Hua Feng2,3,4, Yujie Chen2,3,4, Huilin Cheng1,6
ORCID iDs: Yujie Chen
  1. Department of Neurosurgery, Zhongda Hospital, Southeast University, Nanjing, 210009, China
  2. Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China
  3. Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China
  4. Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China
  5. College of Future Technology, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, 511453, China
  6. Department of Neurosurgery, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210009, China
Institutions: Army Medical University (China); Zhongda Hospital Southeast University (China); Southwest Hospital (China); The Hong Kong University of Science and Technology (Guangzhou) (China); Southeast University (China); Nanjing University (China)
Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, volume 23, issue 2, article e00868
Dates: received 26 November 2025; accepted 24 February 2026; published online 12 March 2026; in print March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.neurot.2026.e00868 · PMID 41825230 · PMCID PMC12996649 · OpenAlex W7135054965
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning
Keywords: Spinal cord injury, H3k27ac, Microglia, Cholesterol metabolism, Scar formation
MeSH: Cholesterol*, Cicatrix*, Histones*, Microglia*, Spinal Cord Injuries*, Acetylation, Animals, Female, Mice, Mice, Inbred C57BL (* major topic)
Topic: Spinal Cord Injury Research (Pathology and Forensic Medicine, Medicine), according to OpenAlex
Funding: National Natural Science Foundation of China (82371333, 82071393); Chongqing Municipal Health Commission (YXGD202451); Natural Science Foundation Project of Chongqing; Natural Science Foundation of Chongqing Municipality (CSTB2025NSCQ-LZX0044); Jiangsu Province Natural Science Foundation (BK20242099)
Citations: cited by 3 papers (Europe PMC); 43 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

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Read it in the paper: doi.org/10.1016/j.neurot.2026.e00868.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 5 keywords, 10 MeSH terms, 5 funders, 43 references.

Cite

This paper

Qiao, Q., Gong, Q., Li, N., Sun, H., Ru, X., Mu, N., Chen, B., Li, W., Chen, T., Feng, H., Chen, Y., & Cheng, H. (2026). Persistent histone H3K27 acetylation contributes to excessive scar formation after spinal cord injury through the regulation of microglial cholesterol accumulation. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 23(2), e00868. https://doi.org/10.1016/j.neurot.2026.e00868

BibTeX

@article{qiao2026persistent,
author = {Qiao, Qiujiang and Gong, Qing and Li, Ning and Sun, Haowei and Ru, Xufang and Mu, Ning and Chen, Beike and Li, Wenyan and Chen, Tunan and Feng, Hua and Chen, Yujie and Cheng, Huilin},
title = {{Persistent histone H3K27 acetylation contributes to excessive scar formation after spinal cord injury through the regulation of microglial cholesterol accumulation}},
journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
year = {2026},
month = mar,
volume = {23},
number = {2},
pages = {e00868},
publisher = {Elsevier},
issn = {1933-7213},
doi = {10.1016/j.neurot.2026.e00868},
url = {https://doi.org/10.1016/j.neurot.2026.e00868},
pmid = {41825230},
pmcid = {PMC12996649}
}

RIS

TY - JOUR
AU - Qiao, Qiujiang
AU - Gong, Qing
AU - Li, Ning
AU - Sun, Haowei
AU - Ru, Xufang
AU - Mu, Ning
AU - Chen, Beike
AU - Li, Wenyan
AU - Chen, Tunan
AU - Feng, Hua
AU - Chen, Yujie
AU - Cheng, Huilin
TI - Persistent histone H3K27 acetylation contributes to excessive scar formation after spinal cord injury through the regulation of microglial cholesterol accumulation
T2 - Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
J2 - Neurotherapeutics
PY - 2026
DA - 2026/03/12
VL - 23
IS - 2
SP - e00868
SN - 1933-7213
PB - Elsevier
DO - 10.1016/j.neurot.2026.e00868
UR - https://doi.org/10.1016/j.neurot.2026.e00868
LA - en
ER -

CSL-JSON

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