OSCR

DNA-based delivery of incretin receptor agonists using MYO Technology leads to durable weight loss in a diet-induced obesity model.

Overview

Authors: Linda Sasset1, Andrew D. Cameron1, Carleigh Sussman1, Luisa Rubinelli1, Debnath Maji1,2, Robert Miller1, Andy Thompson1, Delcora Campbell1, Melanie R. Walker1, Marek M. Drozdz1, Rachel A. Liberatore1
ORCID iDs: Marek M. Drozdz, Rachel A. Liberatore
  1. RenBio Inc., Long Island City, New York, NY 11101, USA
  2. Department of Biological and Agricultural Engineering, Louisiana State University, Baton Rouge, LA 70803, USA
Institutions: RenBio (United States) (United States); Louisiana State University (United States)
Journal: Molecular therapy. Nucleic acids, volume 37, issue 2, article 102946
Dates: received 7 November 2025; accepted 28 April 2026; published online 1 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.omtn.2026.102946 · PMID 42211692 · PMCID PMC13213231 · OpenAlex W4411036133
Open access: gold, a free copy (OpenAlex)
Preprint: doi:10.1101/2025.05.30.656889
Status: code on request (how the code is found and verified)
Categories: other condition (population), cellular / molecular (subfield)
Methods: Statistics, fMRI & imaging
Keywords: MT: RNA/DNA editing, obesity, diabetes, GLP-1, incretin receptor agonist, blood-brain barrier, electroporation, plasmid DNA, DNA platform, MYO technology, DNA medicine
Topic: Photochromic and Fluorescence Chemistry (Materials Chemistry, Materials Science), according to OpenAlex
Funding: RenBio Inc
Citations: not cited yet (Europe PMC); 57 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

The paper's code and data availability statement is in the Data section.

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Data

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Code and data availability statement

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  • it says that the code is available on request

Read it in the paper: doi.org/10.1016/j.omtn.2026.102946.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 11 keywords, 1 funder, 57 references.

Cite

This paper

Sasset, L., Cameron, A. D., Sussman, C., Rubinelli, L., Maji, D., Miller, R., Thompson, A., Campbell, D., Walker, M. R., Drozdz, M. M., & Liberatore, R. A. (2026). DNA-based delivery of incretin receptor agonists using MYO Technology leads to durable weight loss in a diet-induced obesity model. Molecular therapy. Nucleic acids, 37(2), 102946. https://doi.org/10.1016/j.omtn.2026.102946

BibTeX

@article{sasset2026dna,
author = {Sasset, Linda and Cameron, Andrew D. and Sussman, Carleigh and Rubinelli, Luisa and Maji, Debnath and Miller, Robert and Thompson, Andy and Campbell, Delcora and Walker, Melanie R. and Drozdz, Marek M. and Liberatore, Rachel A.},
title = {{DNA-based delivery of incretin receptor agonists using MYO Technology leads to durable weight loss in a diet-induced obesity model}},
journal = {Molecular therapy. Nucleic acids},
year = {2026},
month = may,
volume = {37},
number = {2},
pages = {102946},
publisher = {American Society of Gene \& Cell Therapy},
issn = {2162-2531},
doi = {10.1016/j.omtn.2026.102946},
url = {https://doi.org/10.1016/j.omtn.2026.102946},
pmid = {42211692},
pmcid = {PMC13213231}
}

RIS

TY - JOUR
AU - Sasset, Linda
AU - Cameron, Andrew D.
AU - Sussman, Carleigh
AU - Rubinelli, Luisa
AU - Maji, Debnath
AU - Miller, Robert
AU - Thompson, Andy
AU - Campbell, Delcora
AU - Walker, Melanie R.
AU - Drozdz, Marek M.
AU - Liberatore, Rachel A.
TI - DNA-based delivery of incretin receptor agonists using MYO Technology leads to durable weight loss in a diet-induced obesity model
T2 - Molecular therapy. Nucleic acids
J2 - Mol Ther Nucleic Acids
PY - 2026
DA - 2026/05/01
VL - 37
IS - 2
SP - 102946
SN - 2162-2531
PB - American Society of Gene & Cell Therapy
DO - 10.1016/j.omtn.2026.102946
UR - https://doi.org/10.1016/j.omtn.2026.102946
LA - en
ER -

CSL-JSON

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