Long-term safety and clinical outcomes from a single-site phase 1 study of neural stem cell transplantation for chronic cervical spinal cord injury.
Overview
- Department of Neurological Surgery, University of California, San Diego, La Jolla, CA 92037, USA
- Department of Neurological Surgery, Orlando Health, Orlando, FL 32806, USA
- Department of Medicine, Division of Regenerative Medicine and CIRM Alpha Stem Cell Clinic, University of California, San Diego, La Jolla, CA 92037, USA
- Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92037, USA
Abstract
Neural stem cell transplantation offers a promising avenue for spinal cord injury (SCI) repair, but demonstrating safety and feasibility in human populations remains a critical step. In this phase 1 trial, we investigate the long-term outcomes of cervical spinal cord implantation of NSI-566, a human spinal cord-derived neural stem cell line. With prospective data collection over 60 months, we assess adverse events, functional outcomes, and neurophysiological measures in a small cohort (N = 3) of chronic AIS-A SCI patients. We report a favorable safety profile with no evidence of tumorigenicity or procedure-related complications. Subclinical neurophysiological changes and limited functional gains were observed, although interpretation is constrained by the absence of a control group and the confounding effects of post-operative rehabilitation. These findings support the feasibility of intraparenchymal stem cell delivery for chronic SCI and underscore the need for larger, controlled trials to clarify efficacy and optimize therapeutic parameters.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 6 keywords, 13 MeSH terms, 2 funders, 40 references.
Cite
This paper
Abraham, M. E., Martin, J. R., Seaton, M., Brandel, M. G., Forseth, K. J., Jamieson, C., Marsala, M., & Ciacci, J. D. (2026). Long-term safety and clinical outcomes from a single-site phase 1 study of neural stem cell transplantation for chronic cervical spinal cord injury. Stem cell reports, 21(6), 102926. https://
BibTeX
@article{abraham2026long
author = {Abraham, Mickey E and Martin, Joel R and Seaton, Margaret and Brandel, Michael G and Forseth, Kiefer J and Jamieson, Catriona and Marsala, Martin and Ciacci, Joseph D},
title = {{Long-term safety and clinical outcomes from a single-site phase 1 study of neural stem cell transplantation for chronic cervical spinal cord injury}},
journal = {Stem cell reports},
year = {2026},
month = may,
volume = {21},
number = {6},
pages = {102926},
publisher = {Elsevier},
issn = {2213-6711},
doi = {10.1016/
url = {https://
pmid = {42167221},
pmcid = {PMC13261865}
}
RIS
TY - JOUR
AU - Abraham, Mickey E
AU - Martin, Joel R
AU - Seaton, Margaret
AU - Brandel, Michael G
AU - Forseth, Kiefer J
AU - Jamieson, Catriona
AU - Marsala, Martin
AU - Ciacci, Joseph D
TI - Long-term safety and clinical outcomes from a single-site phase 1 study of neural stem cell transplantation for chronic cervical spinal cord injury
T2 - Stem cell reports
J2 - Stem Cell Reports
PY - 2026
DA - 2026/
VL - 21
IS - 6
SP - 102926
SN - 2213-6711
PB - Elsevier
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
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"author": [
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"language": "en",
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