miR-151-5p regulates neural stem cell fate by targeting APH1A to modulate Notch signaling gradients.
Overview
- State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry & Molecular Biology, Medical Primate Research Center, Neuroscience Center, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China
- State Key Laboratory of Respiratory Health and Multimorbidity, National Center of Technology Innovation for Animal Model, National Human Diseases Animal Model Resource Center, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Institute of Laboratory Animal Sciences, CAMS & PUMC, Beijing 100021, China
Abstract
The precise regulation of neural stem cell (NSC) fate is fundamental to neocortical development. MicroRNAs (miRNAs) are critical post-transcriptional regulators in this process, yet the functions of many remain unknown. Here, we found miR-151-5p is expressed in NSCs of the developing mouse cerebral cortex. Conditional knockout of miR-151-5p increased SOX2 expression in NSCs and enhanced their proliferative capacity. Mechanistically, we identified APH1A, a core subunit of the γ-secretase complex, as a direct target of miR-151-5p. Notably, overexpression of APH1A phenocopied the effects of miR-151-5p knockout, promoting NSC proliferation by elevating NICD levels. These findings demonstrate that miR-151-5p biases NSC fate specification by targeting APH1A to modulate the Notch signaling pathway, thereby fine-tuning the balance between NSC maintenance and differentiation. In summary, our study unveils a novel miR-151-5p/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.
The paper's code and data availability statement is in the Data section.
Tracing map
A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.
Data
No dataset and no data link were found in the paper.
Data and code availability
The RNA-seq data generated in this study have been deposited in GEO (GSE327779). No original code is involved. Additional information required to reanalyze the data in this study is available from the lead contact upon request.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 2, 28 September 2026
- Authors: added Xiaozhong Peng (0000-0002-9592-9554); removed Xiaozhong Peng
Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 5 keywords, 11 MeSH terms, 2 funders, 55 references, 21 RRIDs.
Cite
This paper
Wang, X., Li, L., Chen, Z., Zeng, Y., Shu, P., Hou, L., Yin, B., Liu, W., & Peng, X. (2026). miR-151-5p regulates neural stem cell fate by targeting APH1A to modulate Notch signaling gradients. Stem cell reports, 21(6), 102927. https://
BibTeX
@article{wang2026mir,
author = {Wang, Xinrun and Li, Li and Chen, Zhuo and Zeng, Yi and Shu, Pengcheng and Hou, Lin and Yin, Bin and Liu, Wei and Peng, Xiaozhong},
title = {{miR-151-5p regulates neural stem cell fate by targeting APH1A to modulate Notch signaling gradients}},
journal = {Stem cell reports},
year = {2026},
month = may,
volume = {21},
number = {6},
pages = {102927},
publisher = {Elsevier},
issn = {2213-6711},
doi = {10.1016/
url = {https://
pmid = {42167224},
pmcid = {PMC13261887}
}
RIS
TY - JOUR
AU - Wang, Xinrun
AU - Li, Li
AU - Chen, Zhuo
AU - Zeng, Yi
AU - Shu, Pengcheng
AU - Hou, Lin
AU - Yin, Bin
AU - Liu, Wei
AU - Peng, Xiaozhong
TI - miR-151-5p regulates neural stem cell fate by targeting APH1A to modulate Notch signaling gradients
T2 - Stem cell reports
J2 - Stem Cell Reports
PY - 2026
DA - 2026/
VL - 21
IS - 6
SP - 102927
SN - 2213-6711
PB - Elsevier
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1016/
"type": "article-journal",
"title": "miR-151-5p regulates neural stem cell fate by targeting APH1A to modulate Notch signaling gradients",
"container-title": "Stem cell reports",
"author": [
{
"family": "Wang",
"given": "Xinrun"
},
{
"family": "Li",
"given": "Li"
},
{
"family": "Chen",
"given": "Zhuo"
},
{
"family": "Zeng",
"given": "Yi"
},
{
"family": "Shu",
"given": "Pengcheng"
},
{
"family": "Hou",
"given": "Lin"
},
{
"family": "Yin",
"given": "Bin"
},
{
"family": "Liu",
"given": "Wei"
},
{
"family": "Peng",
"given": "Xiaozhong"
}
],
"container-title-short":
"volume": "21",
"issue": "6",
"page": "102927",
"DOI": "10.1016/
"PMID": "42167224",
"PMCID": "PMC13261887",
"ISSN": "2213-6711",
"publisher": "Elsevier",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
5,
21
]
]
}
}
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.1002/advs.76695
- NSD2 Coordinates the Neurogenic-to-Gliogenic Transition via H3K36me2-Dependent Activation of the EGFR-ERK Pathway.Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)In common: mouse, cellular / molecular, 2 references, author Xiaozhong Peng
- [2] doi:10.1126/sciadv.adw5487 [code]
- Early fate diversification of radial glial progenitors during corticogenesis.Journal: Science advancesIn common: mouse, 4 references
- [3] doi:10.1101/gad.352886.125
- Independent control of neurogenesis and dorsoventral patterning by NKX2-2.Journal: Genes & developmentIn common: mouse, 3 references
- [4] doi:10.1038/s44318-026-00806-z [code]
- Interspecific diversity in the neuronal composition of the mammalian cortex arises from heterochrony in neurogenesis.Journal: The EMBO journalIn common: 3 references
- [5] doi:10.1016/j.stemcr.2026.102930 [code]
- ZFHX4 is necessary for dopaminergic neuron differentiation and controls cell cycle by regulating LIN28A.Journal: Stem cell reportsIn common: cellular / molecular, 2 references
- [6] doi:10.1186/s40478-026-02228-8
- microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer's disease patients.Journal: Acta neuropathologica communicationsIn common: mouse, cellular / molecular, 2 references
- [7] doi:10.7554/elife.107531 [code]
- CellCover defines marker gene panels capturing developmental progression in neocortical neural stem cell identity.Journal: eLifeIn common: mouse, cellular / molecular, 2 references
- [8] doi:10.1101/gad.353090.125 [code]
- Neural stem cell epigenomes and fate bias are temporally coordinated during mouse cortical development.Journal: Genes & developmentIn common: mouse, 2 references
- [9] doi:10.1038/s41420-026-02977-4
- WWP1 gain-of-function drives developmental anoikis through TGFβ pathway during neurodevelopment.Journal: Cell death discoveryIn common: mouse, 2 references
- [10] doi:10.1038/s42003-026-10802-y
- Transcriptome of fetal cortex of tree shrew underlying the emergence of outer subventricular zone.Journal: Communications biologyIn common: 2 references
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Request its removal
To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).
Discussion, reproductions, activity
Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.
Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.