Effects of voluntary exercise, diet, and selenium on hypothalamic adult neurogenesis.
Overview
- School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK
- School of Optometry and Vision Sciences, Cardiff University, Cardiff CF24 4HQ, UK
Abstract
Hypothalamic adult neurogenesis is implicated in energy homeostasis; however, the impact of physical exercise, particularly under high-fat diet (HFD) conditions, on this process remains unclear. To address this, we subjected mice to short-term and long-term voluntary running under control and HFD conditions. We show that long-term, but not short-term, running upregulates hypothalamic neurogenesis in Control mice. Conversely, short-term running rescues HFD-induced neurogenesis in the median eminence (ME), promoting the differentiation and survival of newly generated neurons. This rescue effect is absent with long-term running. Furthermore, we show that selenium mimics the effects of short-term running on ME neurogenesis and increases the activation and proliferation of hypothalamic adult neural stem cells, suggesting its role as a hypothalamic exerkine. Our findings indicate that voluntary exercise differentially influences adult neurogenesis in the hypothalamus compared to the hippocampus, with its neurogenic effects being modulated by diet, exercise duration, and regional differences within hypothalamic compartments.
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.
The paper's code and data availability statement is in the Data section.
Tracing map
A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.
Data
No dataset and no data link were found in the paper.
Data and code availability
Any additional information required to reanalyze the data reported in this paper is available from the lead contact, David Petrik, upon request.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 2, 28 September 2026
- Authors: added David Petrik (0000-0003-3026-0770); removed David Petrik
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 5 authors, 6 keywords, 13 MeSH terms, 1 funder, 44 references, 11 RRIDs.
Cite
This paper
Jörgensen, S. K., Martin, R. E., Want, A., Morgan, J., & Petrik, D. (2026). Effects of voluntary exercise, diet, and selenium on hypothalamic adult neurogenesis. Stem cell reports, 21(7), 102953. https://
BibTeX
@article{jorgensen2026ef
author = {Jörgensen, Sara KM and Martin, Rachel E and Want, Andrew and Morgan, James and Petrik, David},
title = {{Effects of voluntary exercise, diet, and selenium on hypothalamic adult neurogenesis}},
journal = {Stem cell reports},
year = {2026},
month = jun,
volume = {21},
number = {7},
pages = {102953},
publisher = {Elsevier},
issn = {2213-6711},
doi = {10.1016/
url = {https://
pmid = {42276060},
pmcid = {PMC13385432}
}
RIS
TY - JOUR
AU - Jörgensen, Sara KM
AU - Martin, Rachel E
AU - Want, Andrew
AU - Morgan, James
AU - Petrik, David
TI - Effects of voluntary exercise, diet, and selenium on hypothalamic adult neurogenesis
T2 - Stem cell reports
J2 - Stem Cell Reports
PY - 2026
DA - 2026/
VL - 21
IS - 7
SP - 102953
SN - 2213-6711
PB - Elsevier
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1016/
"type": "article-journal",
"title": "Effects of voluntary exercise, diet, and selenium on hypothalamic adult neurogenesis",
"container-title": "Stem cell reports",
"author": [
{
"family": "Jörgensen",
"given": "Sara KM"
},
{
"family": "Martin",
"given": "Rachel E"
},
{
"family": "Want",
"given": "Andrew"
},
{
"family": "Morgan",
"given": "James"
},
{
"family": "Petrik",
"given": "David"
}
],
"container-title-short":
"volume": "21",
"issue": "7",
"page": "102953",
"DOI": "10.1016/
"PMID": "42276060",
"PMCID": "PMC13385432",
"ISSN": "2213-6711",
"publisher": "Elsevier",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
6,
11
]
]
}
}
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.1016/j.celrep.2026.117685
- Tanycyte BMAL1 regulates high-fat diet weight gain and shapes arcuate neurogenesis in female mice.Journal: Cell reportsIn common: developmental, mouse, 6 references
- [2] doi:10.1038/s41467-026-74598-5 [code]
- A synaptoid connectome differentiates tanycytic subpopulations and underlies neuroglial communication and neuroendocrine regulation.Journal: Nature communicationsIn common: mouse, 3 references
- [3] doi:10.1002/advs.76479
- RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle-Brain Communication.Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)In common: developmental, 2 references
- [4] doi:10.1016/j.stemcr.2026.102958 [code]
- Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders.Journal: Stem cell reportsIn common: 2 references
- [5] doi:10.1126/sciadv.adt2527
- NPAS3-regulated astrocyte mitochondrial bioenergetics is required for cognition.Journal: Science advancesIn common: mouse, 2 references
- [6] doi:10.1111/jnc.70448
- Hydroxytyrosol Mitigates Anxiety-Like Behaviors After a Traumatic Experience in Aged Mice in Parallel With Increased Neurogenesis in the Ventral and Dorsal Dentate Gyrus, and Preservation of Gut Microbiota Composition.Journal: Journal of neurochemistryIn common: developmental, mouse, 1 reference
- [7] doi:10.1038/s41467-026-75063-z
- Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming.Journal: Nature communicationsIn common: developmental, mouse, 1 reference
- [8] doi:10.1523/jneurosci.0019-26.2026 [code]
- Endothelial &
lt;i& gt;Adgrl2& lt;/ i& gt; Expression and Alternative Splicing Controls the Cerebrovasculature. Journal: The Journal of neuroscience : the official journal of the Society for NeuroscienceIn common: mouse, 2 references - [9] doi:10.1016/j.cub.2026.03.031 [code]
- Acute requirement for the hippocampus in putatively conscious vision revealed by a mouse model of blindsight.Journal: Current biology : CBIn common: mouse, 2 references
- [10] doi:10.1002/hipo.70099 [code]
- The Dentate Gyrus Grows Throughout Life Despite Turnover of Developmentally-Born Neurons.Journal: HippocampusIn common: developmental, 1 reference
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Request its removal
To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).
Discussion, reproductions, activity
Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.
Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.