OSCR

Tanycyte BMAL1 regulates high-fat diet weight gain and shapes arcuate neurogenesis in female mice.

Overview

Authors: Daniel Maxim Iascone1,2, Pavel Pivarshev1, Jianing Yang1, Mariela Lopez Valencia1, Sara B. Noya1, Hongtong Lin1, Corey D. Holman3, Ron C. Anafi4, Joseph L. Bedont1,5, Amita Sehgal1,6
ORCID iDs: Daniel Maxim Iascone, Hongtong Lin, Amita Sehgal
  1. Howard Hughes Medical Institute, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  2. Present address: Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA
  3. Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  4. Department of Medicine, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  5. Present address: Department of Biological Sciences, Kent State University, Kent, OH, USA
  6. Lead contact
Institutions: Howard Hughes Medical Institute (United States); University of Pennsylvania (United States)
Journal: Cell reports, volume 45, issue 7, article 117685
Dates: published online 13 July 2026; in print 28 July 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1016/j.celrep.2026.117685 · PMID 42441404 · PMCID PMC13470997 · OpenAlex W7168168871
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: mouse (organism), developmental (subfield)
Methods: Statistics
Keywords: Hypothalamus, Sex, Neurogenesis, Feeding, Weight, tanycyte, Glia, Circadian, Arcuate, Bmal1, Cp: Neuroscience
MeSH: Arcuate Nucleus of Hypothalamus*, ARNTL Transcription Factors*, Diet, High-Fat*, Ependymoglial Cells*, Neurogenesis*, Weight Gain*, Animals, Female, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Neurons (* major topic)
Topic: Circadian rhythm and melatonin (Endocrine and Autonomic Systems, Neuroscience), according to OpenAlex
Funding: NIMH NIH HHS (F32 MH125600); National Institute of Mental Health and Neurosciences; National Institute of Neurological Disorders and Stroke; NIA NIH HHS (R01 AG068577, F32 AG056081); Howard Hughes Medical Institute; National Institute of Diabetes and Digestive and Kidney Diseases; NINDS NIH HHS (R00 NS118561, K99 NS118561); NICHD NIH HHS (U54 HD086984); National Institute on Aging; NIDDK NIH HHS (K99 DK142063); NIH HHS (S10 OD025098)
Citations: cited by 1 paper (Europe PMC); 70 references in the paper
Research resources: Goat anti-NPY RRID:AB_10009813, Rabbit anti-BMAL1 RRID:AB_2258598, Rabbit anti-POMC RRID:AB_2307442, Alexa Fluor® 488 Donkey Anti-Goat IgG RRID:AB_2534102, Alexa Fluor® 647 Donkey Anti-Rabbit IgG RRID:AB_2536183, Alexa Fluor® 488 Donkey Anti-Rabbit IgG RRID:AB_2762833, C57BL/6J RRID:IMSR_JAX:000664, RRID:IMSR_JAX:007668, RRID:IMSR_JAX:007914, RRID:IMSR_JAX:009100, Raxtm1.1(cre/ERT2)Sbls/J (RaxCreER) RRID:IMSR_JAX:025521, FIJI (ImageJ) RRID:SCR_002285, Prism 10 GraphPad RRID:SCR_002798, Clocklab RRID:SCR_014309, CalR2 RRID:SCR_015849, JTK_CYCLE RRID:SCR_017962, RRID:SCR_022427, MetaCycle R RRID:SCR_025729

Abstract

The hypothalamic radial-glia-like tanycyte population plays important and intertwined roles in metabolism, reproduction, and seasonality. Although these processes are circadian-regulated, the role of the molecular clock in tanycytes themselves has not yet been examined. We report that clock genes cycle with much higher amplitude in ventral tanycytes compared to more dorsal ependymocytes and that adult, tanycyte-specific knockout of core clock gene Bmal1 reduces diet-associated weight gain and fat mass in female mice. Fate mapping studies show that female mice have higher baseline tanycyte-derived neurogenesis than males, with many of the resulting neurons localizing to the feeding-relevant arcuate nucleus. Female but not male mice show reduced tanycyte-derived arcuate neurogenesis after adult Bmal1 deletion, with an increased proportion of newborn neurons acquiring a feeding-suppressing POMC neuropeptidergic fate. Together, our data support a role for tanycyte BMAL1 as a sex-specific regulator of body composition and hypothalamic adult neurogenesis.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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Data

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Data and code availability

Data reported in this paper will be shared by the lead contact upon request.

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Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Publisher: — → Cell Press

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 11 keywords, 13 MeSH terms, 11 funders, 68 references, 18 RRIDs.

Cite

This paper

Iascone, D. M., Pivarshev, P., Yang, J., Valencia, M. L., Noya, S. B., Lin, H., Holman, C. D., Anafi, R. C., Bedont, J. L., & Sehgal, A. (2026). Tanycyte BMAL1 regulates high-fat diet weight gain and shapes arcuate neurogenesis in female mice. Cell reports, 45(7), 117685. https://doi.org/10.1016/j.celrep.2026.117685

BibTeX

@article{iascone2026tanycyte,
author = {Iascone, Daniel Maxim and Pivarshev, Pavel and Yang, Jianing and Valencia, Mariela Lopez and Noya, Sara B. and Lin, Hongtong and Holman, Corey D. and Anafi, Ron C. and Bedont, Joseph L. and Sehgal, Amita},
title = {{Tanycyte BMAL1 regulates high-fat diet weight gain and shapes arcuate neurogenesis in female mice}},
journal = {Cell reports},
year = {2026},
month = jul,
volume = {45},
number = {7},
pages = {117685},
publisher = {Cell Press},
issn = {2211-1247},
doi = {10.1016/j.celrep.2026.117685},
url = {https://doi.org/10.1016/j.celrep.2026.117685},
pmid = {42441404},
pmcid = {PMC13470997}
}

RIS

TY - JOUR
AU - Iascone, Daniel Maxim
AU - Pivarshev, Pavel
AU - Yang, Jianing
AU - Valencia, Mariela Lopez
AU - Noya, Sara B.
AU - Lin, Hongtong
AU - Holman, Corey D.
AU - Anafi, Ron C.
AU - Bedont, Joseph L.
AU - Sehgal, Amita
TI - Tanycyte BMAL1 regulates high-fat diet weight gain and shapes arcuate neurogenesis in female mice
T2 - Cell reports
J2 - Cell Rep
PY - 2026
DA - 2026/07/13
VL - 45
IS - 7
SP - 117685
SN - 2211-1247
PB - Cell Press
DO - 10.1016/j.celrep.2026.117685
UR - https://doi.org/10.1016/j.celrep.2026.117685
LA - en
ER -

CSL-JSON

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