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Brain corticogenesis promotes SARS-CoV-2 neuro-glial tropism through lipid-dependent viral replication.

Overview

Authors: Byoung-San Moon1, Dae-Gyun Ahn2, Jieun Park3, Nhu Thi Quynh Mai1, Da-Jin Jeong1, Hyowon Hong4, Sae-Bom Yoon4, Sunhee Lee2, Gun Young Yoon2, Chonsaeng Kim2, Keun Bon Ku2, Hye Jin Nam4, Ihn-Sil Kwak5, Seong-Jun Kim6,7, Heeyeong Cho4
ORCID iDs: Byoung-San Moon, Dae-Gyun Ahn
  1. Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea
  2. Department of Convergent Research of Emerging Virus Infection, Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Korea
  3. Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
  4. Drug Discovery Platform Research Center, Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Korea
  5. Department of Ocean Integrated Science, Chonnam National University, Yeosu 59626, Korea
  6. Untreatable Infectious Disease Institute, Kyungpook National University, Daegu 41944, Korea
  7. Department of Microbiology, School of Medicine, Kyungpook National University, Daegu 41944, Korea
Institutions: Yeungnam University (South Korea); Korea Research Institute of Chemical Technology (South Korea); University of North Carolina at Chapel Hill (United States); Chonnam National University (South Korea); Kyungpook National University (South Korea)
Journal: Stem cell reports, volume 21, issue 8, article 103020
Dates: received 29 March 2025; accepted 23 June 2026; published online 23 July 2026; in print August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.stemcr.2026.103020 · PMID 42492515 · PMCID PMC13476884 · OpenAlex W7170130958
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Connectivity
Keywords: human induced pluripotent stem cell, hIPSC, brain organoid, SARS-CoV-2, corticogenesis, gliogenesis, lipid metabolism, neurotropism
MeSH: Brain*, Cerebral Cortex*, COVID-19*, Neuroglia*, SARS-CoV-2*, Viral Tropism*, Virus Replication*, Animals, Humans, Induced Pluripotent Stem Cells, Lipid Metabolism (* major topic)
Topic: Long-Term Effects of COVID-19 (Neurology, Medicine), according to OpenAlex
Funding: Ministry of Health & Welfare; Ministry of Food and Drug Safety (RS-2024-00332014); Korea Health Technology; Korea Health Industry Development Institute; Republic of Korea (RS-2025-02303821); National Research Foundation of Korea; Korean government (RS-2024-00455950, RS-2024-00338945, NRF-2018-R1A6A1A-03024314); Korea Research Institute of Chemical Technology (KK2631-10); National Research Council of Science & Technology; Korea government; Ministry of Science and ICT, South Korea (GTL24022-000)
Citations: not cited yet (Europe PMC); 80 references in the paper
Research resources: Rabbit monoclonal anti-SOX2 RRID:AB_10585428, Rabbit monoclonal anti-TMPRSS2 RRID:AB_10863728, Rabbit monoclonal anti-ACE2 RRID:AB_10864415, Rat monoclonal anti-CTIP2 RRID:AB_2064130, Rabbit polyclonal anti-TBR1 RRID:AB_2200219, RRID:AB_2576208, RRID:AB_2630356, Rabbit monoclonal anti-GAPDH RRID:AB_2630358, RRID:AB_2650513, RRID:AB_2687594, RRID:AB_2722511, RRID:AB_2722519, Rabbit polyclonal anti-FADS2 RRID:AB_2804393, Rabbit monoclonal anti-FDFT1 RRID:AB_2860018, Rabbit polyclonal anti-MSMO1 RRID:AB_2860020, Rabbit monoclonal anti-MBP RRID:AB_2895537, Rabbit polyclonal anti-PAX6 RRID:AB_291612, Mouse monoclonal anti-Ki67 RRID:AB_2934265, Mouse monoclonal anti-MAP2 RRID:AB_3094449, Mouse monoclonal anti-GFAP RRID:AB_449329, Mouse monoclonal anti-SREBP1 RRID:AB_628282, Rabbit monoclonal anti-ClCas3 RRID:AB_725946, Rabbit polyclonal anti-LDLR RRID:AB_881272, Mouse monoclonal anti-SATB2 RRID:AB_882455, Human: SH-SY5Y neuroblastoma RRID:CVCL_0019, Human: IMR-90 hiPSC RRID:CVCL_0347, Green monkey: Vero E6 (VERO C1008) RRID:CVCL_0574, Human: MO3.13 Oligodendrocyte RRID:CVCL_D357, Human: hFmiPSC2 (KSCBi002-B-1) RRID:CVCL_IT65, Mouse: C57BL/6J RRID:IMSR_JAX:000664

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

Tracing map

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Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1016/j.stemcr.2026.103020.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Authors: added Byoung-San Moon (0000-0002-5405-6048); removed Byoung-San Moon

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 15 authors, 8 keywords, 11 MeSH terms, 11 funders, 80 references, 30 RRIDs.

Cite

This paper

Moon, B.-S., Ahn, D.-G., Park, J., Mai, N. T. Q., Jeong, D.-J., Hong, H., Yoon, S.-B., Lee, S., Yoon, G. Y., Kim, C., Ku, K. B., Nam, H. J., Kwak, I.-S., Kim, S.-J., & Cho, H. (2026). Brain corticogenesis promotes SARS-CoV-2 neuro-glial tropism through lipid-dependent viral replication. Stem cell reports, 21(8), 103020. https://doi.org/10.1016/j.stemcr.2026.103020

BibTeX

@article{moon2026brain,
author = {Moon, Byoung-San and Ahn, Dae-Gyun and Park, Jieun and Mai, Nhu Thi Quynh and Jeong, Da-Jin and Hong, Hyowon and Yoon, Sae-Bom and Lee, Sunhee and Yoon, Gun Young and Kim, Chonsaeng and Ku, Keun Bon and Nam, Hye Jin and Kwak, Ihn-Sil and Kim, Seong-Jun and Cho, Heeyeong},
title = {{Brain corticogenesis promotes SARS-CoV-2 neuro-glial tropism through lipid-dependent viral replication}},
journal = {Stem cell reports},
year = {2026},
month = jul,
volume = {21},
number = {8},
pages = {103020},
publisher = {Elsevier},
issn = {2213-6711},
doi = {10.1016/j.stemcr.2026.103020},
url = {https://doi.org/10.1016/j.stemcr.2026.103020},
pmid = {42492515},
pmcid = {PMC13476884}
}

RIS

TY - JOUR
AU - Moon, Byoung-San
AU - Ahn, Dae-Gyun
AU - Park, Jieun
AU - Mai, Nhu Thi Quynh
AU - Jeong, Da-Jin
AU - Hong, Hyowon
AU - Yoon, Sae-Bom
AU - Lee, Sunhee
AU - Yoon, Gun Young
AU - Kim, Chonsaeng
AU - Ku, Keun Bon
AU - Nam, Hye Jin
AU - Kwak, Ihn-Sil
AU - Kim, Seong-Jun
AU - Cho, Heeyeong
TI - Brain corticogenesis promotes SARS-CoV-2 neuro-glial tropism through lipid-dependent viral replication
T2 - Stem cell reports
J2 - Stem Cell Reports
PY - 2026
DA - 2026/07/23
VL - 21
IS - 8
SP - 103020
SN - 2213-6711
PB - Elsevier
DO - 10.1016/j.stemcr.2026.103020
UR - https://doi.org/10.1016/j.stemcr.2026.103020
LA - en
ER -

CSL-JSON

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"language": "en",
"issued": {
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