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Escherichia coli Nissle 1917 alleviates Alzheimer's disease in mice through OmpA-containing outer membrane vesicles.

Overview

Authors: Junhua Xie1, Xi-jian Dai2,3,4, Qiqiong Li1, Wanyu Zhang1, Xinke Nie1, Haihua Ji1, Xinyang Chen1, Yuchen Wang5, Jing Feng5, Zhipeng Li5, Qiong Liu6, Jianxin Ye7, Guangzhi Zhang7, Shaoping Nie1
ORCID iDs: Xinyang Chen, Shaoping Nie
  1. State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, Jiangxi, China
  2. Department of Radiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China
  3. Jiangxi Provincial Key Laboratory of Intelligent Medical Imaging, Nanchang 330006, China
  4. Nanchang Key Laboratory of Medical-Engineering Integration and Clinical Translation, Nanchang 330006, China
  5. College of Food Science and Technology, Nanchang University, Nanchang 330031, China
  6. Department of Medical Microbiology, School of Medicine, Nanchang University, Nanchang 330006, China
  7. Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Institutions: Nanchang University (China); Second Affiliated Hospital of Nanchang University (China); Chinese Academy of Agricultural Sciences (China); Institute of Animal Sciences (China)
Journal: Cell reports. Medicine, volume 7, issue 5, article 102781
Dates: received 20 June 2025; accepted 3 April 2026; published online 30 April 2026; in print May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.xcrm.2026.102781 · PMID 42066770 · PMCID PMC13198242 · OpenAlex W7159872527
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: human (organism), mouse (organism), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Connectivity
Keywords: Escherichia coli Nissle 1917, probiotic, outer membrane vesicles, Alzheimer’s disease, gut-brain axis, outer membrane protein A, vagus nerve, neuro-immune interaction, gut microbiota, synaptic dysfunction
MeSH: Alzheimer Disease*, Bacterial Outer Membrane Proteins*, Escherichia coli*, Probiotics*, Animals, Astrocytes, Brain, Disease Models, Animal, Female, Gastrointestinal Microbiome, Humans, Male, Mice, Mice, Inbred C57BL, Microglia, Neurons (* major topic)
Topic: Bacterial Infections and Vaccines (Microbiology, Immunology and Microbiology), according to OpenAlex
Funding: National Key Research and Development Project (2024YFF1106000); Natural Science Foundation of Jiangxi (20242BAB21031); Technological Project of Jiangxi Province (20232BCD44003); Postdoctoral Fellowship Program of CPSF (GZB20230284); National Natural Science Foundation of China (National Science Foundation of China) (82572200, 82460341); Science Foundation for Distinguished Young Scholars (20242BAB23086); Jiangxi Province Higher Education Association (ZN-D-014); Nanchang University (JXYJG-2025-063)
Citations: cited by 8 papers (Europe PMC); 82 references in the paper
Research resources: Alexa Fluor 568 goat anti-rat RRID:AB_141874, Rabbit anti-Synaptophysin RRID:AB_2286949, Alexa Flour 488 goat anti-mouse RRID:AB_2534069, Alexa Fluor 633 goat anti-rabbit RRID:AB_2535731, Mouse anti-β-Amyloid RRID:AB_2564653, Rat anti-CD31 RRID:AB_2631039, Rat anti-CD68 RRID:AB_324217, Mouse anti-Ki-67 RRID:AB_393778, PE Rat Anti-Mouse CD86 RRID:AB_394994, Rabbit anti-ZO-1 RRID:AB_617300, Rabbit anti-Cre RRID:AB_838061, Rabbit anti-IBA1 RRID:AB_839504, Mouse anti-Occludin RRID:AB_87033

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Read it in the paper: doi.org/10.1016/j.xcrm.2026.102781.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 10 keywords, 16 MeSH terms, 8 funders, 82 references, 13 RRIDs.

Cite

This paper

Xie, J., Dai, X.-j., Li, Q., Zhang, W., Nie, X., Ji, H., Chen, X., Wang, Y., Feng, J., Li, Z., Liu, Q., Ye, J., Zhang, G., & Nie, S. (2026). Escherichia coli Nissle 1917 alleviates Alzheimer's disease in mice through OmpA-containing outer membrane vesicles. Cell reports. Medicine, 7(5), 102781. https://doi.org/10.1016/j.xcrm.2026.102781

BibTeX

@article{xie2026escherichia,
author = {Xie, Junhua and Dai, Xi-jian and Li, Qiqiong and Zhang, Wanyu and Nie, Xinke and Ji, Haihua and Chen, Xinyang and Wang, Yuchen and Feng, Jing and Li, Zhipeng and Liu, Qiong and Ye, Jianxin and Zhang, Guangzhi and Nie, Shaoping},
title = {{Escherichia coli Nissle 1917 alleviates Alzheimer's disease in mice through OmpA-containing outer membrane vesicles}},
journal = {Cell reports. Medicine},
year = {2026},
month = apr,
volume = {7},
number = {5},
pages = {102781},
publisher = {Elsevier},
issn = {2666-3791},
doi = {10.1016/j.xcrm.2026.102781},
url = {https://doi.org/10.1016/j.xcrm.2026.102781},
pmid = {42066770},
pmcid = {PMC13198242}
}

RIS

TY - JOUR
AU - Xie, Junhua
AU - Dai, Xi-jian
AU - Li, Qiqiong
AU - Zhang, Wanyu
AU - Nie, Xinke
AU - Ji, Haihua
AU - Chen, Xinyang
AU - Wang, Yuchen
AU - Feng, Jing
AU - Li, Zhipeng
AU - Liu, Qiong
AU - Ye, Jianxin
AU - Zhang, Guangzhi
AU - Nie, Shaoping
TI - Escherichia coli Nissle 1917 alleviates Alzheimer's disease in mice through OmpA-containing outer membrane vesicles
T2 - Cell reports. Medicine
J2 - Cell Rep Med
PY - 2026
DA - 2026/04/30
VL - 7
IS - 5
SP - 102781
SN - 2666-3791
PB - Elsevier
DO - 10.1016/j.xcrm.2026.102781
UR - https://doi.org/10.1016/j.xcrm.2026.102781
LA - en
ER -

CSL-JSON

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