OSCR

Ketogenic diet as a metabolic vehicle enhancing the therapeutic efficacy of mebendazole and devimistat in juvenile syngeneic high-grade glioma.

Overview

Authors: Purna Mukherjee1, Jack Maurer1, Sylwia A. Stopka2, Bennett Greenwood2, Juan J. Aristizabal-Henao2, Srada Karmacharya2, Alexandra Chimento1, Nathan Ta1, Derek C. Lee1, Tomas Duraj1, Roderick T. Bronson3, Michael A. Kiebish2, Thomas N. Seyfried1
ORCID iDs: Thomas N. Seyfried
  1. Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
  2. BPGbio, Framingham, MA 01701, USA
  3. Rodent Pathology Core, Harvard Medical School, Boston, MA 02215, USA
Institutions: Boston College (United States); BPGbio, Inc. (United States) (United States); Harvard University (United States)
Journal: Cell reports. Medicine, volume 7, issue 6, article 102845
Dates: received 25 November 2025; accepted 11 May 2026; published online 16 June 2026; in print June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.xcrm.2026.102845 · PMID 42302750 · PMCID PMC13293999 · OpenAlex W7164933035
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: human (organism), mouse (organism), other condition (population), clinical / translational (subfield)
Methods: Statistics
Keywords: spinal cord, glutaminolysis, glycolysis, metabolic therapy, press-pulse, glutamine, childhood brain cancer, glucose, ketones
MeSH: Brain Neoplasms*, Diet, Ketogenic*, Glioma*, Mebendazole*, Animals, Cell Line, Tumor, Cell Proliferation, Female, Glycolysis, Humans, Mice (* major topic)
Topic: Diet and metabolism studies (Physiology, Medicine), according to OpenAlex
Funding: University of Kentucky, United States; Kenneth Rainin Foundation; Delaware; Boston College
Citations: cited by 2 papers (Europe PMC); 101 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

The paper's code and data availability statement is in the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.

Data

No dataset and no data link were found in the paper.

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the data are available on request
  • it says that the code is available on request

Read it in the paper: doi.org/10.1016/j.xcrm.2026.102845.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Authors: added Thomas N. Seyfried (0000-0003-1491-3989); removed Thomas N. Seyfried

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 9 keywords, 11 MeSH terms, 4 funders, 101 references.

Cite

This paper

Mukherjee, P., Maurer, J., Stopka, S. A., Greenwood, B., Aristizabal-Henao, J. J., Karmacharya, S., Chimento, A., Ta, N., Lee, D. C., Duraj, T., Bronson, R. T., Kiebish, M. A., & Seyfried, T. N. (2026). Ketogenic diet as a metabolic vehicle enhancing the therapeutic efficacy of mebendazole and devimistat in juvenile syngeneic high-grade glioma. Cell reports. Medicine, 7(6), 102845. https://doi.org/10.1016/j.xcrm.2026.102845

BibTeX

@article{mukherjee2026ketogenic,
author = {Mukherjee, Purna and Maurer, Jack and Stopka, Sylwia A. and Greenwood, Bennett and Aristizabal-Henao, Juan J. and Karmacharya, Srada and Chimento, Alexandra and Ta, Nathan and Lee, Derek C. and Duraj, Tomas and Bronson, Roderick T. and Kiebish, Michael A. and Seyfried, Thomas N.},
title = {{Ketogenic diet as a metabolic vehicle enhancing the therapeutic efficacy of mebendazole and devimistat in juvenile syngeneic high-grade glioma}},
journal = {Cell reports. Medicine},
year = {2026},
month = jun,
volume = {7},
number = {6},
pages = {102845},
publisher = {Elsevier},
issn = {2666-3791},
doi = {10.1016/j.xcrm.2026.102845},
url = {https://doi.org/10.1016/j.xcrm.2026.102845},
pmid = {42302750},
pmcid = {PMC13293999}
}

RIS

TY - JOUR
AU - Mukherjee, Purna
AU - Maurer, Jack
AU - Stopka, Sylwia A.
AU - Greenwood, Bennett
AU - Aristizabal-Henao, Juan J.
AU - Karmacharya, Srada
AU - Chimento, Alexandra
AU - Ta, Nathan
AU - Lee, Derek C.
AU - Duraj, Tomas
AU - Bronson, Roderick T.
AU - Kiebish, Michael A.
AU - Seyfried, Thomas N.
TI - Ketogenic diet as a metabolic vehicle enhancing the therapeutic efficacy of mebendazole and devimistat in juvenile syngeneic high-grade glioma
T2 - Cell reports. Medicine
J2 - Cell Rep Med
PY - 2026
DA - 2026/06/01
VL - 7
IS - 6
SP - 102845
SN - 2666-3791
PB - Elsevier
DO - 10.1016/j.xcrm.2026.102845
UR - https://doi.org/10.1016/j.xcrm.2026.102845
LA - en
ER -

CSL-JSON

{
"id": "10.1016/j.xcrm.2026.102845",
"type": "article-journal",
"title": "Ketogenic diet as a metabolic vehicle enhancing the therapeutic efficacy of mebendazole and devimistat in juvenile syngeneic high-grade glioma",
"container-title": "Cell reports. Medicine",
"author": [
{
"family": "Mukherjee",
"given": "Purna"
},
{
"family": "Maurer",
"given": "Jack"
},
{
"family": "Stopka",
"given": "Sylwia A."
},
{
"family": "Greenwood",
"given": "Bennett"
},
{
"family": "Aristizabal-Henao",
"given": "Juan J."
},
{
"family": "Karmacharya",
"given": "Srada"
},
{
"family": "Chimento",
"given": "Alexandra"
},
{
"family": "Ta",
"given": "Nathan"
},
{
"family": "Lee",
"given": "Derek C."
},
{
"family": "Duraj",
"given": "Tomas"
},
{
"family": "Bronson",
"given": "Roderick T."
},
{
"family": "Kiebish",
"given": "Michael A."
},
{
"family": "Seyfried",
"given": "Thomas N."
}
],
"container-title-short": "Cell Rep Med",
"volume": "7",
"issue": "6",
"page": "102845",
"DOI": "10.1016/j.xcrm.2026.102845",
"PMID": "42302750",
"PMCID": "PMC13293999",
"ISSN": "2666-3791",
"publisher": "Elsevier",
"URL": "https://doi.org/10.1016/j.xcrm.2026.102845",
"language": "en",
"issued": {
"date-parts": [
[
2026,
6,
1
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.3390/microorganisms14061175
Susceptibility of the Placenta and Fetal Brain to Maternal Probiotic Supplementation.
Journal: Microorganisms
In common: 2 references
[2] doi:10.1038/s42003-026-09780-y
Downfield magnetic resonance signals serve as endogenous imaging biomarkers of nucleotide metabolism in glioma.
Journal: Communications biology
In common: clinical / translational, other condition, 1 reference
[3] doi:10.1016/j.omtn.2026.103036
NADPH oxidase 3 inhibition preserves hearing in mice after stereotactic radiosurgery.
Journal: Molecular therapy. Nucleic acids
In common: other condition, mouse, 1 reference
[4] doi:10.1016/j.omtn.2026.102942
AAV9-mediated targeting of natural antisense transcript as a novel treatment for Dravet syndrome.
Journal: Molecular therapy. Nucleic acids
In common: clinical / translational, mouse, 1 reference
[5] doi:10.1016/j.xpro.2026.104801 [code]
Protocol to characterize tumor microenvironment in a diffuse midline glioma mouse model using multi-omics approach on sequential sections.
Journal: STAR protocols
In common: other condition, mouse, 1 reference
[6] doi:10.1186/s13020-026-01445-6
Electroacupuncture enhances anti-tumor immunity in TNBC by reducing NE release and blocking α2-AR-mediated NGF/Hippo signaling.
Journal: Chinese medicine
In common: other condition, mouse, 1 reference
[7] doi:10.1016/j.isci.2026.116242 [code]
Brain and central nervous system cancer burden in children across Asia.
Journal: iScience
In common: other condition, 1 reference
[8] doi:10.1038/s41419-026-08891-y
Microglia in diffuse midline glioma contribute to extracellular matrix remodelling and cancer cell invasion.
Journal: Cell death & disease
In common: other condition, 1 reference
[9] doi:10.1016/j.xcrm.2026.102766 [code]
A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma.
Journal: Cell reports. Medicine
In common: other condition, 1 reference
[10] doi:10.3390/ijms27114833
Alterations in the Components of the GABA-Glutamate System During ZIKV Infection: A Neuroscience Approach.
Journal: International journal of molecular sciences
In common: other condition, mouse, 1 reference

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.