Cortical-to-pallidal beta cascade underlies network pathophysiology in Parkinson's disease.

Overview

Authors: Jeong Woo Choi¹, Amirreza Alijanpourotaghsara¹, Koorosh Mirpour¹, Sahil Chilukuri¹, Nader Pouratian^1,2

ORCID iDs: Nader Pouratian

Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

Institutions: The University of Texas Southwestern Medical Center (United States)

Journal: Cell reports. Medicine, volume 7, issue 9, article 103001

Dates: received 24 December 2025; accepted 25 July 2026; published online 21 August 2026; in print September 2026

Type: Research article · Language: English

License: CC BY-NC

Identifiers: DOI 10.1016/j.xcrm.2026.103001 · PMID 42628526 · PMCID PMC13589497 · OpenAlex W7203858308

Open access: gold, a free copy (OpenAlex)

Status: code on request

Categories: human (organism), Parkinson's (population)

Methods: Spectral & time-frequency, Preprocessing, Connectivity, Statistics, Evoked potentials, Machine learning

Keywords: Parkinson’s disease, beta oscillations, network pathophysiology, network synchrony, dopaminergic therapy

MeSH: Beta Rhythm*, Globus Pallidus*, Motor Cortex*, Parkinson Disease*, Aged, Deep Brain Stimulation, Female, Humans, Male, Middle Aged (* major topic)

Topic: Neurological disorders and treatments (Neurology, Medicine), according to OpenAlex

Funding: NINDS NIH HHS (R01 NS097782)

Citations: not cited yet (Europe PMC); 59 references in the paper

Abstract

Parkinson’s disease (PD) motor symptoms are linked to excessive beta band (13–35 Hz) oscillations and basal ganglia-cortical (BGC) synchrony, yet their dynamic inter-relation remains unclear. Based on computational modeling, we hypothesize that transient high-beta (20–35 Hz) BGC coupling induces subcortical low-beta (13–20 Hz) amplification. We recorded intraoperative neural signals from the globus pallidus internus and externus (GPi and GPe, respectively) and motor cortex (M1) in 23 PD patients during deep brain stimulation implantation. High-beta bursts in M1 and GPe were classified as either temporally synchronized or isolated. Synchronous M1-GPe high-beta bursts led by GPe were followed by GPi low-beta amplification, which were not evident with either isolated M1 high-beta bursts or M1-led synchronous bursts. Dopaminergic medication attenuated this GPi low-beta amplification and improved symptoms. These findings suggest that excessive M1 high-beta bursts following GPe high-beta activity trigger a cascade establishing low-beta propagation to GPi, which may contribute to PD motor dysfunction.

Reproduced under the paper's license (CC BY-NC), from the paper cited above.

Code

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The paper's code and data availability statement is in the Data section.

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Data

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Data and code availability

All raw data reported in this paper have been deposited in Data Archive for the BRAIN Initiative (DABI; https://dabi.loni.usc.edu/projects/1U01NS098961) and the Brain Integrated Resource for Human Anatomy and Intracranial Neurophysiology (B(RAIN)2; https://doi.org/10.18120/zmah-2816) and are publicly available as of the date of publication. All the original data will be shared by the lead contact upon request.

This study did not report any custom code.

Any additional information required to reanalyze the data reported in this paper is available from lead contact upon request.

Reproduced under the paper's license (CC BY-NC), from the paper cited above.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 5 authors, 5 keywords, 10 MeSH terms, 1 funder, 56 references.

Cite

This paper

Choi, J. W., Alijanpourotaghsara, A., Mirpour, K., Chilukuri, S., & Pouratian, N. (2026). Cortical-to-pallidal beta cascade underlies network pathophysiology in Parkinson's disease. Cell reports. Medicine, 7(9), 103001. https://doi.org/10.1016/j.xcrm.2026.103001

BibTeX

@article{choi2026cortical, author = {Choi, Jeong Woo and Alijanpourotaghsara, Amirreza and Mirpour, Koorosh and Chilukuri, Sahil and Pouratian, Nader}, title = {{Cortical-to-pallidal beta cascade underlies network pathophysiology in Parkinson's disease}}, journal = {Cell reports. Medicine}, year = {2026}, month = aug, volume = {7}, number = {9}, pages = {103001}, publisher = {Elsevier}, issn = {2666-3791}, doi = {10.1016/j.xcrm.2026.103001}, url = {https://doi.org/10.1016/j.xcrm.2026.103001}, pmid = {42628526}, pmcid = {PMC13589497} }

RIS

TY - JOUR AU - Choi, Jeong Woo AU - Alijanpourotaghsara, Amirreza AU - Mirpour, Koorosh AU - Chilukuri, Sahil AU - Pouratian, Nader TI - Cortical-to-pallidal beta cascade underlies network pathophysiology in Parkinson's disease T2 - Cell reports. Medicine J2 - Cell Rep Med PY - 2026 DA - 2026/08/21 VL - 7 IS - 9 SP - 103001 SN - 2666-3791 PB - Elsevier DO - 10.1016/j.xcrm.2026.103001 UR - https://doi.org/10.1016/j.xcrm.2026.103001 LA - en ER -

CSL-JSON

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