Protocol for mouse vascular dementia model and evaluation of progressive tissue damage in subcortical white matter and adjacent cortex.
Overview
- Thrust of Bioscience and Biomedical Engineering, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511400, China
- Department of Neurosurgery, Stanford University, Palo Alto, CA 94304, USA
- Department of Neurology, the David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Abstract
Here, we present a protocol for generating a vascular dementia (VaD) mouse model through stereotaxic microinjection of a vasoconstrictor into the subcortical white matter (WM). We describe steps for preparing the N5-(1-iminoethyl)-L-orni
For complete details on the use and execution of this protocol, please refer to Tian et al.1
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.
The paper's code and data availability statement is in the Data section.
Tracing map
A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.
Data
No dataset and no data link were found in the paper.
Data and code availability
All raw and analyzed data are available upon request. No code is used in the current study.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 3 authors, 3 keywords, 7 MeSH terms, 5 funders, 15 references, 16 RRIDs.
Cite
This paper
Tian, M., Llorente, I. L., & Carmichael, S. T. (2026). Protocol for mouse vascular dementia model and evaluation of progressive tissue damage in subcortical white matter and adjacent cortex. STAR protocols, 7(1), 104396. https://
BibTeX
@article{tian2026protoco
author = {Tian, Min and Llorente, Irene L. and Carmichael, S. Thomas},
title = {{Protocol for mouse vascular dementia model and evaluation of progressive tissue damage in subcortical white matter and adjacent cortex}},
journal = {STAR protocols},
year = {2026},
month = mar,
volume = {7},
number = {1},
pages = {104396},
publisher = {Elsevier},
issn = {2666-1667},
doi = {10.1016/
url = {https://
pmid = {41779617},
pmcid = {PMC12969622}
}
RIS
TY - JOUR
AU - Tian, Min
AU - Llorente, Irene L.
AU - Carmichael, S. Thomas
TI - Protocol for mouse vascular dementia model and evaluation of progressive tissue damage in subcortical white matter and adjacent cortex
T2 - STAR protocols
J2 - STAR Protoc
PY - 2026
DA - 2026/
VL - 7
IS - 1
SP - 104396
SN - 2666-1667
PB - Elsevier
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1016/
"type": "article-journal",
"title": "Protocol for mouse vascular dementia model and evaluation of progressive tissue damage in subcortical white matter and adjacent cortex",
"container-title": "STAR protocols",
"author": [
{
"family": "Tian",
"given": "Min"
},
{
"family": "Llorente",
"given": "Irene L."
},
{
"family": "Carmichael",
"given": "S. Thomas"
}
],
"container-title-short":
"volume": "7",
"issue": "1",
"page": "104396",
"DOI": "10.1016/
"PMID": "41779617",
"PMCID": "PMC12969622",
"ISSN": "2666-1667",
"publisher": "Elsevier",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
3,
3
]
]
}
}
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.64898/2026.08.12.26360241
- Diffusion kurtosis imaging (gen)omics unravels mechanisms of cerebral small vessel diseaseJournal: medRxiv (preprint)In common: stroke, Alzheimer's / dementia, 2 references
- [2] doi:10.1186/s43556-026-00546-w
- Silencing arachidonate 15-lipoxygenase alleviates hypoxia-induced cognitive impairment through the mediation of phospholipase A2 group IVC-LPC18:0 to suppress ferroptosis.Journal: Molecular biomedicineIn common: histology / microscopy, Alzheimer's / dementia, mouse, 1 reference
- [3] doi:10.1038/s41598-026-54533-w
- Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1.Journal: Scientific reportsIn common: stroke, Alzheimer's / dementia, mouse, 1 reference
- [4] doi:10.3389/fnut.2026.1837406 [code]
- MIND diet moderates the associations between cerebrovascular and neurodegenerative disease burden and cognition.Journal: Frontiers in nutritionIn common: stroke, Alzheimer's / dementia, 1 reference
- [5] doi:10.1002/alz.71433
- Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry.Journal: Alzheimer's & dementia : the journal of the Alzheimer's AssociationIn common: stroke, Alzheimer's / dementia, 1 reference
- [6] doi:10.1136/svn-2025-004208 [code]
- Genetically predicted white matter microstructure mediates the relationship between risk factors and lacunar stroke.Journal: Stroke and vascular neurologyIn common: stroke, 1 reference
- [7] doi:10.1093/brain/awag033
- Impairment of hippocampal gamma oscillations, mitochondria and neurovascular function in CADASIL.Journal: Brain : a journal of neurologyIn common: stroke, histology / microscopy, Alzheimer's / dementia, 1 other category
- [8] doi:10.1002/hbm.70508 [code]
- Cyclic 2.5D Perceptual Loss for Cross-Modal 3D Medical Image Synthesis: T1w MRI to Tau PET.Journal: Human brain mappingIn common: Alzheimer's / dementia, 1 reference
- [9] doi:10.1371/journal.pcbi.1014576 [code]
- A synthetic 3D human cerebrovascular model informed by histology for simulating the cortical depth-dependent BOLD fMRI signal.Journal: PLoS computational biologyIn common: stroke, histology / microscopy, mouse
- [10] doi:10.1002/cns.71080
- Vorinostat Mitigates Early Brain Injury Following Subarachnoid Hemorrhage Through Modulation of the C3aR1/
TGF-β/ Smad Pathway. Journal: CNS neuroscience & therapeuticsIn common: stroke, histology / microscopy, mouse
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Request its removal
To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).
Discussion, reproductions, activity
Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.
Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.