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Integration of Network Pharmacology, Molecular Docking, and Molecular Dynamics to Decipher the Multi-Target Mechanisms of Crocin I in Parkinson's Disease with In Vivo Validation.

Overview

Authors: Jing Wang1,2,3, Mengna Lv1,2,3, Jingyi Yu4, Yanwu Xu5, Yudong Lin1,2, Jin Pei3, Mingmei Zhou1,2
ORCID iDs: Mingmei Zhou
  1. Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China
  2. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  3. State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
  4. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  5. The Institute of Basic Theory of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Institutions: Shanghai University of Traditional Chinese Medicine (China); Shanghai Traditional Chinese Medicine Hospital (China); Chengdu University of Traditional Chinese Medicine (China)
Journal: ACS omega, volume 11, issue 19, pages 27787-27804
Dates: received 7 October 2025; accepted 23 April 2026; published online 5 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1021/acsomega.5c10445 · PMID 42179644 · PMCID PMC13191495 · OpenAlex W7160280932
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: Parkinson's (population), cellular / molecular (subfield)
Methods: Statistics, Graphs
Topic: Saffron Plant Research Studies (Oncology, Medicine), according to OpenAlex
Funding: Chengdu University of Traditional Chinese Medicine (SKLTCM2022021); Shanghai University of Traditional Chinese Medicine (201203); Chengdu University
Citations: not cited yet (Europe PMC); 49 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1021/acsomega.5c10445.

Versions

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Version 2, 28 September 2026

  • Funding: added Chengdu University of Traditional Chinese Medicine: SKLTCM2022021; Shanghai University of Traditional Chinese Medicine: 201203; Chengdu University

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 47 references.

Cite

This paper

Wang, J., Lv, M., Yu, J., Xu, Y., Lin, Y., Pei, J., & Zhou, M. (2026). Integration of Network Pharmacology, Molecular Docking, and Molecular Dynamics to Decipher the Multi-Target Mechanisms of Crocin I in Parkinson's Disease with In Vivo Validation. ACS omega, 11(19), 27787-27804. https://doi.org/10.1021/acsomega.5c10445

BibTeX

@article{wang2026integration,
author = {Wang, Jing and Lv, Mengna and Yu, Jingyi and Xu, Yanwu and Lin, Yudong and Pei, Jin and Zhou, Mingmei},
title = {{Integration of Network Pharmacology, Molecular Docking, and Molecular Dynamics to Decipher the Multi-Target Mechanisms of Crocin I in Parkinson's Disease with In Vivo Validation}},
journal = {ACS omega},
year = {2026},
month = may,
volume = {11},
number = {19},
pages = {27787--27804},
publisher = {American Chemical Society},
issn = {2470-1343},
doi = {10.1021/acsomega.5c10445},
url = {https://doi.org/10.1021/acsomega.5c10445},
pmid = {42179644},
pmcid = {PMC13191495}
}

RIS

TY - JOUR
AU - Wang, Jing
AU - Lv, Mengna
AU - Yu, Jingyi
AU - Xu, Yanwu
AU - Lin, Yudong
AU - Pei, Jin
AU - Zhou, Mingmei
TI - Integration of Network Pharmacology, Molecular Docking, and Molecular Dynamics to Decipher the Multi-Target Mechanisms of Crocin I in Parkinson's Disease with In Vivo Validation
T2 - ACS omega
J2 - ACS Omega
PY - 2026
DA - 2026/05/05
VL - 11
IS - 19
SP - 27787
EP - 27804
SN - 2470-1343
PB - American Chemical Society
DO - 10.1021/acsomega.5c10445
UR - https://doi.org/10.1021/acsomega.5c10445
LA - en
ER -

CSL-JSON

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"container-title": "ACS omega",
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"language": "en",
"issued": {
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}

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