OSCR

Exploring the Interactive Effect of Pectins from <i>Campomanesia xanthocarpa</i> with Galectin‑3.

Overview

Authors: Isabela P Dias1, Gabriela Casani Cardoso2, Lucas V dos Santos1, Giovanna Furman1, Ester Mazepa1, Téo F Minella3, Marcelo D Baruffi4, Luisa Mestriner4, Andrey F Z Nascimento5, Lindomar J C Albuquerque5, Keylla L Mischiatti3, Edneia A S Ramos2,6, Elaine C de Abreu7, Sheila M Brochado Winnischofer1,3, Sarah da Costa Amaral1, Joana Léa Meira da Silveira1, Guilherme F Picheth1,3
ORCID iDs: Gabriela Casani Cardoso, Lucas V dos Santos, Lindomar J C Albuquerque, Guilherme F Picheth
  1. Postgraduate Program in Biochemistry Sciences, Federal University of Paraná, Curitiba, Paraná 80060-000, Brazil
  2. Post-Graduate Program in Microbiology, Parasitology and Pathology, Federal University of Paraná, Curitiba, Paraná 80060-000, Brazil
  3. Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, Paraná 80060-000, Brazil
  4. Department of Clinical, Toxicological and Bromatological Analysis, University of São Paulo, Ribeirão Preto, São Paulo 14040-903, Brazil
  5. Brazilian Synchrotron Light Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, São Paulo 13083-100, Brazil
  6. Department of Basic Pathology, Federal University of Paraná, Curitiba, Paraná 80060-000, Brazil
  7. Center for Advanced Fluorescence Technologies from the Federal University of Paraná - CTAF/UFPR, Curitiba, Paraná 81531-980, Brazil
Institutions: Universidade Federal do Paraná (Brazil); Universidade de São Paulo (Brazil); Brazilian Synchrotron Light Laboratory (Brazil); Brazilian Center for Research in Energy and Materials (Brazil)
Journal: ACS omega, volume 11, issue 14, pages 22379-22390
Dates: received 11 February 2026; accepted 25 March 2026; published online 2 April 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1021/acsomega.6c01637 · PMID 42004375 · PMCID PMC13084385 · OpenAlex W7147406705
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: other condition (population), cellular / molecular (subfield)
Methods: Statistics, Preprocessing, Graphs
Topic: Galectins and Cancer Biology (Immunology, Immunology and Microbiology), according to OpenAlex
Funding: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil (CAPES) (00x0MA614, 1798682); Conselho Nacional de Desenvolvimento Científico e Tecnológico (309225/2018-3, 312827/2021-0, 406645/2022‐1, 406973/2022–9, 308296/2015–0, 476950/2013-9); Universidade Federal Do Paraná
Citations: not cited yet (Europe PMC); 74 references in the paper

Abstract

Glioblastoma (GBM) is a fast-growing and aggressive primary brain tumor with an average survival time of 12–18 months. GBM growth and invasion rely on multiple and dynamic signaling events in the tumor microenvironment, in which several glycan-binding proteins act as essential mediators. Among them, galectin-3 (Gal-3) plays a key role in cell–cell and cell–extracellular matrix communication. Gal-3 may be inhibited by complex polysaccharides such as pectins, which might reduce GBM aggressiveness and invasiveness. To identify possible interactive mechanisms involving Gal-3, we have selectively modified the structure of pectins extracted fromCampomanesia xanthocarpa Berg to obtain varied GalA:Ara and Gal:Ara ratios along the polysaccharide backbone. The interactive influence of the fully modified structures as well as the individual monosaccharides was monitored by circular dichroism and X-ray diffraction. The impact of all modified pectins on the T98G and U87MG cell viability and Gal-3 expression was also evaluated. Our results suggest that galactose and galacturonic acid may be partly responsible for the protein structural changes. The pectins induced significant cytotoxicity and reduced Gal-3 expression in vitro, suggesting that biomaterials with a similar Gal:Ara ratio may be employed as adjuvants in GBM therapy.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

rcsb.org/structure/9d62

License: none: the authors keep all their rights
State: the link answers, verified on 28 September 2026
Evidence: the link answers
Software Heritage: not checked
Found in: the text, “Gal-3hT X-ray Diffraction and Data Analysis”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 28 September 2026: the link answers (HTTP 200)
  • 28 September 2026: the link answers (HTTP 200)
At the source: rcsb.org/structure/9D62

rcsb.org/structure/9d63

License: none: the authors keep all their rights
State: the link answers, verified on 28 September 2026
Evidence: the link answers
Software Heritage: not checked
Found in: the text, “Gal-3hT X-ray Diffraction and Data Analysis”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 28 September 2026: the link answers (HTTP 200)
  • 28 September 2026: the link answers (HTTP 200)
At the source: rcsb.org/structure/9D63

rcsb.org/structure/9d64

License: none: the authors keep all their rights
State: the link answers, verified on 28 September 2026
Evidence: the link answers
Software Heritage: not checked
Found in: the text, “Gal-3hT X-ray Diffraction and Data Analysis”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 28 September 2026: the link answers (HTTP 200)
  • 28 September 2026: the link answers (HTTP 200)
At the source: rcsb.org/structure/9D64

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

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  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
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Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Funding: added Coordenação de Aperfeiçoamento de Pessoal de Nível Superior: 00x0MA614, 1798682; Conselho Nacional de Desenvolvimento Científico e Tecnológico: 309225/2018-3, 312827/2021-0, 406645/2022‐1, 406973/2022–9, 308296/2015–0, 476950/2013-9; Universidade Federal do Paraná

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 17 authors, 74 references.

Cite

This paper

Dias, I. P., Casani Cardoso, G., dos Santos, L. V., Furman, G., Mazepa, E., Minella, T. F., Baruffi, M. D., Mestriner, L., Nascimento, A. F. Z., Albuquerque, L. J. C., Mischiatti, K. L., Ramos, E. A. S., de Abreu, E. C., Brochado Winnischofer, S. M., Amaral, S. d. C., da Silveira, J. L. M., & Picheth, G. F. (2026). Exploring the Interactive Effect of Pectins from <i>Campomanesia xanthocarpa</i> with Galectin‑3. ACS omega, 11(14), 22379-22390. https://doi.org/10.1021/acsomega.6c01637

BibTeX

@article{dias2026exploring,
author = {Dias, Isabela P and Casani Cardoso, Gabriela and dos Santos, Lucas V and Furman, Giovanna and Mazepa, Ester and Minella, Téo F and Baruffi, Marcelo D and Mestriner, Luisa and Nascimento, Andrey F Z and Albuquerque, Lindomar J C and Mischiatti, Keylla L and Ramos, Edneia A S and de Abreu, Elaine C and Brochado Winnischofer, Sheila M and Amaral, Sarah da Costa and da Silveira, Joana Léa Meira and Picheth, Guilherme F},
title = {{Exploring the Interactive Effect of Pectins from \<i\>Campomanesia xanthocarpa\</i\> with Galectin‑3}},
journal = {ACS omega},
year = {2026},
month = apr,
volume = {11},
number = {14},
pages = {22379--22390},
publisher = {American Chemical Society},
issn = {2470-1343},
doi = {10.1021/acsomega.6c01637},
url = {https://doi.org/10.1021/acsomega.6c01637},
pmid = {42004375},
pmcid = {PMC13084385}
}

RIS

TY - JOUR
AU - Dias, Isabela P
AU - Casani Cardoso, Gabriela
AU - dos Santos, Lucas V
AU - Furman, Giovanna
AU - Mazepa, Ester
AU - Minella, Téo F
AU - Baruffi, Marcelo D
AU - Mestriner, Luisa
AU - Nascimento, Andrey F Z
AU - Albuquerque, Lindomar J C
AU - Mischiatti, Keylla L
AU - Ramos, Edneia A S
AU - de Abreu, Elaine C
AU - Brochado Winnischofer, Sheila M
AU - Amaral, Sarah da Costa
AU - da Silveira, Joana Léa Meira
AU - Picheth, Guilherme F
TI - Exploring the Interactive Effect of Pectins from <i>Campomanesia xanthocarpa</i> with Galectin‑3
T2 - ACS omega
J2 - ACS Omega
PY - 2026
DA - 2026/04/02
VL - 11
IS - 14
SP - 22379
EP - 22390
SN - 2470-1343
PB - American Chemical Society
DO - 10.1021/acsomega.6c01637
UR - https://doi.org/10.1021/acsomega.6c01637
LA - en
ER -

CSL-JSON

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