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Gut microbiota modulation via repeated donor fecal transplantation improves motor and gastrointestinal symptoms in drug-naïve Parkinson's disease: a randomized phase 2 trial.

Overview

Authors: Rui Zhang1,2,3,4, Renyi Feng1,2,3,4, Jiuqi Wang1,2,3,4, Yongkang Chen4, Han Liu4, Qingyong Zhu4, Haiyan Tian4, Chi Qin4, Junfang Teng4, Beisha Tang5,6, Min Wu7,8, Jinsheng Zeng1,2,3, Erxi Wu9,10,11,12, Xuebing Ding1,2,3,4, Xuejing Wang1,2,3,4,5,6
ORCID iDs: Beisha Tang, Min Wu, Erxi Wu
  1. Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong China
  2. Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, Guangzhou, Guangdong China
  3. National Key Clinical Department and Key Discipline of Neurology, Guangzhou, Guangdong China
  4. Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan China
  5. Department of Neurology, Multi-Omics Research Center for Brain Disorders, the First Affiliated Hospital, University of South China, Hengyang, Hunan China
  6. Clinical Research Center for Immune-Related Encephalopathy of Hunan Province, Hengyang, Hunan China
  7. Drug Discovery Center, Wenzhou Institute University of Chinese Academy of Sciences, Wenzhou, Zhejiang China
  8. Department of Medicine, Harvard Medical School, and Brigham and Women’s Hospital, Boston, MA USA
  9. Neuroscience Institute and Department of Neurosurgery, Baylor Scott & White Health, Temple, TX USA
  10. Department of Neurosurgery, Baylor College of Medicine, Temple, TX USA
  11. Naresh K. Vashisht College of Medicine and Irma Lerma Rangel College of Pharmacy, Texas A&M University, College Station, TX USA
  12. Livestrong Cancer Institutes and Department of Internal Medicine, Dell Medical School, the University of Texas at Austin, Austin, TX USA
Institutions: The First Affiliated Hospital, Sun Yat-sen University (China); First Affiliated Hospital of Zhengzhou University (China); First Affiliated Hospital of University of South China (China); University of South China (China); Brigham and Women's Hospital (United States); Harvard University (United States); Wenzhou Institute, University of Chinese Academy of Sciences (China); Baylor College of Medicine (United States); Baylor Scott & White Medical Center - Temple (United States); Baylor Scott & White Health (United States); The University of Texas at Austin (United States); Texas A&M University (United States); Zhengzhou University (China)
Journal: Signal transduction and targeted therapy, volume 11, issue 1, article 94
Dates: received 14 July 2025; accepted 20 January 2026; published online 13 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41392-026-02604-9 · PMID 41826284 · PMCID PMC12987940 · OpenAlex W7135171361
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: human (organism), other condition (population), Parkinson's (population), clinical / translational (subfield)
Methods: Statistics, Connectivity
Keywords: Neurodevelopmental disorders, Neuroimmunology
MeSH: Constipation*, Fecal Microbiota Transplantation*, Gastrointestinal Microbiome*, Parkinson Disease*, Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Quality of Life (* major topic)
Topic: Gut microbiota and health (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (National Science Foundation of China) (82122022,82471272, 82171248, 82471350, 82201407, 82130035, 82371308); Sun Yat-sen University (SYSU) (R04017)
Citations: cited by 4 papers (Europe PMC); 39 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Code availability statement

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  • it says that the code is available on request

Read it in the paper: doi.org/10.1038/s41392-026-02604-9.

Tracing map

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Data

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Data availability statement

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Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 15 authors, 2 keywords, 11 MeSH terms, 2 funders, 39 references.

Cite

This paper

Zhang, R., Feng, R., Wang, J., Chen, Y., Liu, H., Zhu, Q., Tian, H., Qin, C., Teng, J., Tang, B., Wu, M., Zeng, J., Wu, E., Ding, X., & Wang, X. (2026). Gut microbiota modulation via repeated donor fecal transplantation improves motor and gastrointestinal symptoms in drug-naïve Parkinson's disease: a randomized phase 2 trial. Signal transduction and targeted therapy, 11(1), 94. https://doi.org/10.1038/s41392-026-02604-9

BibTeX

@article{zhang2026gut,
author = {Zhang, Rui and Feng, Renyi and Wang, Jiuqi and Chen, Yongkang and Liu, Han and Zhu, Qingyong and Tian, Haiyan and Qin, Chi and Teng, Junfang and Tang, Beisha and Wu, Min and Zeng, Jinsheng and Wu, Erxi and Ding, Xuebing and Wang, Xuejing},
title = {{Gut microbiota modulation via repeated donor fecal transplantation improves motor and gastrointestinal symptoms in drug-naïve Parkinson's disease: a randomized phase 2 trial}},
journal = {Signal transduction and targeted therapy},
year = {2026},
month = mar,
volume = {11},
number = {1},
pages = {94},
publisher = {Nature Publishing Group},
issn = {2095-9907},
doi = {10.1038/s41392-026-02604-9},
url = {https://doi.org/10.1038/s41392-026-02604-9},
pmid = {41826284},
pmcid = {PMC12987940}
}

RIS

TY - JOUR
AU - Zhang, Rui
AU - Feng, Renyi
AU - Wang, Jiuqi
AU - Chen, Yongkang
AU - Liu, Han
AU - Zhu, Qingyong
AU - Tian, Haiyan
AU - Qin, Chi
AU - Teng, Junfang
AU - Tang, Beisha
AU - Wu, Min
AU - Zeng, Jinsheng
AU - Wu, Erxi
AU - Ding, Xuebing
AU - Wang, Xuejing
TI - Gut microbiota modulation via repeated donor fecal transplantation improves motor and gastrointestinal symptoms in drug-naïve Parkinson's disease: a randomized phase 2 trial
T2 - Signal transduction and targeted therapy
J2 - Signal Transduct Target Ther
PY - 2026
DA - 2026/03/13
VL - 11
IS - 1
SP - 94
SN - 2095-9907
PB - Nature Publishing Group
DO - 10.1038/s41392-026-02604-9
UR - https://doi.org/10.1038/s41392-026-02604-9
LA - en
ER -

CSL-JSON

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