OSCR

Knockdown of Ddx3x in mPFC induces autistic-like phenotype in mice via altered synaptic plasticity.

Overview

Authors: Hongbin Zhuang1, Xueshan Cao1, Xiaoxiao Tang1, Zhiyuan Liang1, Hanghang Wang1, Qiong Liu1,2, Xi Yan1, Xixiao Lin1, Xiaoxi Su1, Mingxian Wang1, Yuhan Huang1, Dinglin Lu1, Yiyuan Wang1, Haiyi Chen1, Liming Shen1,2
ORCID iDs: Qiong Liu, Yuhan Huang, Liming Shen
  1. College of Life Science and Oceanography, Shenzhen University, Shenzhen, 518071 P. R. China
  2. Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055 P. R. China
Institutions: Shenzhen University (China); Shenzhen-Hong Kong Institute of Brain Science (China)
Journal: Translational psychiatry, volume 16, issue 1, article 216
Dates: received 21 June 2025; accepted 6 March 2026; published online 30 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41398-026-03945-3 · PMID 41912502 · PMCID PMC13039147 · OpenAlex W7143354589
Open access: gold, a free copy (OpenAlex)
Status: data only (how the code is found and verified)
Categories: genetics / omics (modality), histology / microscopy (modality), mouse (organism), autism (population), cellular / molecular (subfield)
Methods: Statistics, Evoked potentials, Smoothing, state filtering, decompositions
Keywords: Neuroscience, Physiology
MeSH: Autism Spectrum Disorder*, Autistic Disorder*, DEAD-box RNA Helicases*, Neuronal Plasticity*, Prefrontal Cortex*, Animals, Disease Models, Animal, Gene Knockdown Techniques, Male, Mice, Phenotype, Proteomics (* major topic)
Topic: Congenital heart defects research (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (National Science Foundation of China) (31870825)
Citations: not cited yet (Europe PMC); 89 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41398-026-03945-3.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 15 authors, 2 keywords, 12 MeSH terms, 1 funder, 89 references.

Cite

This paper

Zhuang, H., Cao, X., Tang, X., Liang, Z., Wang, H., Liu, Q., Yan, X., Lin, X., Su, X., Wang, M., Huang, Y., Lu, D., Wang, Y., Chen, H., & Shen, L. (2026). Knockdown of Ddx3x in mPFC induces autistic-like phenotype in mice via altered synaptic plasticity. Translational psychiatry, 16(1), 216. https://doi.org/10.1038/s41398-026-03945-3

BibTeX

@article{zhuang2026knockdown,
author = {Zhuang, Hongbin and Cao, Xueshan and Tang, Xiaoxiao and Liang, Zhiyuan and Wang, Hanghang and Liu, Qiong and Yan, Xi and Lin, Xixiao and Su, Xiaoxi and Wang, Mingxian and Huang, Yuhan and Lu, Dinglin and Wang, Yiyuan and Chen, Haiyi and Shen, Liming},
title = {{Knockdown of Ddx3x in mPFC induces autistic-like phenotype in mice via altered synaptic plasticity}},
journal = {Translational psychiatry},
year = {2026},
month = mar,
volume = {16},
number = {1},
pages = {216},
publisher = {Nature Publishing Group},
issn = {2158-3188},
doi = {10.1038/s41398-026-03945-3},
url = {https://doi.org/10.1038/s41398-026-03945-3},
pmid = {41912502},
pmcid = {PMC13039147}
}

RIS

TY - JOUR
AU - Zhuang, Hongbin
AU - Cao, Xueshan
AU - Tang, Xiaoxiao
AU - Liang, Zhiyuan
AU - Wang, Hanghang
AU - Liu, Qiong
AU - Yan, Xi
AU - Lin, Xixiao
AU - Su, Xiaoxi
AU - Wang, Mingxian
AU - Huang, Yuhan
AU - Lu, Dinglin
AU - Wang, Yiyuan
AU - Chen, Haiyi
AU - Shen, Liming
TI - Knockdown of Ddx3x in mPFC induces autistic-like phenotype in mice via altered synaptic plasticity
T2 - Translational psychiatry
J2 - Transl Psychiatry
PY - 2026
DA - 2026/03/30
VL - 16
IS - 1
SP - 216
SN - 2158-3188
PB - Nature Publishing Group
DO - 10.1038/s41398-026-03945-3
UR - https://doi.org/10.1038/s41398-026-03945-3
LA - en
ER -

CSL-JSON

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