OSCR

Explainable drug side effect prediction in central neural system via biologically informed graph neural network.

Overview

Authors: Tongtong Huang1, Ko-Hong Lin1, Rodrigo Machado-Vieira2, Jair C Soares2, Xiaoqian Jiang1, Yejin Kim1
  1. McWilliams School of Biomedical Informatics, UTHealth, Houston, TX US
  2. Department of Psychiatry and Behavioral Sciences, McGovern Medical School, UTHealth, Houston, TX US
Journal: Translational psychiatry, volume 16, issue 1, article 205
Dates: received 28 August 2024; accepted 6 March 2026; published online 25 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41398-026-03971-1 · PMID 41876492 · PMCID PMC13040068 · OpenAlex W7140236155
Open access: gold, a free copy (OpenAlex)
Status: empty repository (how the code is found and verified)
Categories: human (organism)
Methods: Machine learning, Preprocessing, Statistics
Keywords: Pharmacology, Psychiatric disorders
MeSH: Central Nervous System*, Graph Neural Networks*, Animals, Humans (* major topic)
Topic: Computational Drug Discovery Methods (Drug Discovery, Pharmacology, Toxicology and Pharmaceutics), according to OpenAlex
Funding: Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) (R01AG084637, U01CA274576, U01AG079847, U24AG098157, R01LM013712, R01LM014520, R01AG082721, R01AG066749); NIA NIH HHS (R01 AG084637, R01 AG082721); National Science Foundation (NSF) (#2124789)
Citations: not cited yet (Europe PMC); 70 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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tongtong-h/HHAN_DSI

License: none: the authors keep all their rights
State: the link answers, verified on 30 September 2026
Evidence: files inventoried
Size: 0 files, 0 scripts
Software Heritage: not archived
Found in: “Code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 30 September 2026: the link answers
  • 30 September 2026: the link answers

Code availability statement

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Read it in the paper: doi.org/10.1038/s41398-026-03971-1.

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1038/s41398-026-03971-1.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 2 keywords, 4 MeSH terms, 3 funders, 57 references.

Cite

This paper

Huang, T., Lin, K.-H., Machado-Vieira, R., Soares, J. C., Jiang, X., & Kim, Y. (2026). Explainable drug side effect prediction in central neural system via biologically informed graph neural network. Translational psychiatry, 16(1), 205. https://doi.org/10.1038/s41398-026-03971-1

BibTeX

@article{huang2026explainable,
author = {Huang, Tongtong and Lin, Ko-Hong and Machado-Vieira, Rodrigo and Soares, Jair C and Jiang, Xiaoqian and Kim, Yejin},
title = {{Explainable drug side effect prediction in central neural system via biologically informed graph neural network}},
journal = {Translational psychiatry},
year = {2026},
month = mar,
volume = {16},
number = {1},
pages = {205},
publisher = {Nature Publishing Group},
issn = {2158-3188},
doi = {10.1038/s41398-026-03971-1},
url = {https://doi.org/10.1038/s41398-026-03971-1},
pmid = {41876492},
pmcid = {PMC13040068}
}

RIS

TY - JOUR
AU - Huang, Tongtong
AU - Lin, Ko-Hong
AU - Machado-Vieira, Rodrigo
AU - Soares, Jair C
AU - Jiang, Xiaoqian
AU - Kim, Yejin
TI - Explainable drug side effect prediction in central neural system via biologically informed graph neural network
T2 - Translational psychiatry
J2 - Transl Psychiatry
PY - 2026
DA - 2026/03/25
VL - 16
IS - 1
SP - 205
SN - 2158-3188
PB - Nature Publishing Group
DO - 10.1038/s41398-026-03971-1
UR - https://doi.org/10.1038/s41398-026-03971-1
LA - en
ER -

CSL-JSON

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"volume": "16",
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"PMCID": "PMC13040068",
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"publisher": "Nature Publishing Group",
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