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Identifying novel gene dysregulation associated with opioid overdose death: a meta-analysis of differential gene expression in human prefrontal cortex.

Overview

Authors: Javan K. Carter1, Bryan C. Quach1, Caryn Willis1, Melyssa S. Minto1, Dana B. Hancock1, Janitza Montalvo-Ortiz2,3, Olivia Corradin4, Ryan W. Logan5,6, Consuelo Walss-Bass7,8, Brion S. Maher9, PGC-SUD Epigenetics Working Group, Eric Otto Johnson1,10
ORCID iDs: Bryan C. Quach, Caryn Willis, Melyssa S. Minto, Dana B. Hancock, Janitza Montalvo-Ortiz, Olivia Corradin, Ryan W. Logan, Brion S. Maher, Eric Otto Johnson
  1. Omics, Epidemiology, and Analytics Program, RTI International, Research Triangle Park,Durham, NC USA
  2. Department of Psychiatry, Division of Human Genetics, Yale School of Medicine,New Haven, CT USA
  3. Clinical Neurosciences Division, National Center of PTSD, VA CT Healthcare System,West Haven, CT USA
  4. Whitehead Institute Biomedical Research,Cambridge, MA USA
  5. Department of Psychiatry, University of Massachusetts Chan Medical School,Worcester, MA USA
  6. Department of Neurobiology, University of Massachusetts Chan Medical School,Worcester, MA USA
  7. Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston,Houston, TX USA
  8. MD Anderson Cancer Center University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences,Houston, TX USA
  9. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health,Baltimore, MD USA
  10. Fellow Program, RTI International, Research Triangle Park,Durham, NC USA
Institutions: RTI International (United States); Yale University (United States); Clinical Neurosciences Division, National Center of PTSD, VA CT Healthcare System,West Haven, CT USA; Whitehead Institute for Biomedical Research (United States); University of Massachusetts Chan Medical School (United States); The University of Texas Health Science Center at Houston (United States); Johns Hopkins University (United States)
Journal: Translational psychiatry, volume 16, issue 1, article 335
Dates: received 10 March 2025; accepted 10 March 2026; published online 8 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41398-026-03977-9 · PMID 42103735 · PMCID PMC13338397 · OpenAlex W4390838416
Open access: gold, a free copy (OpenAlex)
Preprint: doi:10.1101/2024.01.12.24301153
Status: data only
Categories: genetics / omics (modality), human (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Machine learning
Keywords: Molecular neuroscience, Addiction, Comparative genomics, Clinical genetics
MeSH: Gene Expression Regulation*, Opiate Overdose*, Prefrontal Cortex*, Gene Expression Profiling, Humans, Transcriptome (* major topic)
Topic: Neurotransmitter Receptor Influence on Behavior (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: National Institute on Drug Abuse (DA05471, DA043980, DA050160, DA051390, DA044859)
Citations: cited by 1 paper (Europe PMC); 94 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1038/s41398-026-03977-9.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 4 keywords, 6 MeSH terms, 1 funder, 85 references.

Cite

This paper

Carter, J. K., Quach, B. C., Willis, C., Minto, M. S., Hancock, D. B., Montalvo-Ortiz, J., Corradin, O., Logan, R. W., Walss-Bass, C., Maher, B. S., PGC-SUD Epigenetics Working Group, & Johnson, E. O. (2026). Identifying novel gene dysregulation associated with opioid overdose death: a meta-analysis of differential gene expression in human prefrontal cortex. Translational psychiatry, 16(1), 335. https://doi.org/10.1038/s41398-026-03977-9

BibTeX

@article{carter2026identifying,
author = {Carter, Javan K. and Quach, Bryan C. and Willis, Caryn and Minto, Melyssa S. and Hancock, Dana B. and Montalvo-Ortiz, Janitza and Corradin, Olivia and Logan, Ryan W. and Walss-Bass, Consuelo and Maher, Brion S. and {PGC-SUD Epigenetics Working Group} and Johnson, Eric Otto},
title = {{Identifying novel gene dysregulation associated with opioid overdose death: a meta-analysis of differential gene expression in human prefrontal cortex}},
journal = {Translational psychiatry},
year = {2026},
month = may,
volume = {16},
number = {1},
pages = {335},
publisher = {Nature Publishing Group},
issn = {2158-3188},
doi = {10.1038/s41398-026-03977-9},
url = {https://doi.org/10.1038/s41398-026-03977-9},
pmid = {42103735},
pmcid = {PMC13338397}
}

RIS

TY - JOUR
AU - Carter, Javan K.
AU - Quach, Bryan C.
AU - Willis, Caryn
AU - Minto, Melyssa S.
AU - Hancock, Dana B.
AU - Montalvo-Ortiz, Janitza
AU - Corradin, Olivia
AU - Logan, Ryan W.
AU - Walss-Bass, Consuelo
AU - Maher, Brion S.
AU - PGC-SUD Epigenetics Working Group
AU - Johnson, Eric Otto
TI - Identifying novel gene dysregulation associated with opioid overdose death: a meta-analysis of differential gene expression in human prefrontal cortex
T2 - Translational psychiatry
J2 - Transl Psychiatry
PY - 2026
DA - 2026/05/08
VL - 16
IS - 1
SP - 335
SN - 2158-3188
PB - Nature Publishing Group
DO - 10.1038/s41398-026-03977-9
UR - https://doi.org/10.1038/s41398-026-03977-9
LA - en
ER -

CSL-JSON

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