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Chemogenetic modulation of the prelimbic cortex to the nucleus accumbens core pathway reduces cocaine-induced increase of risk preference.

Overview

Authors: Joonyeup Han1,2, Myung Ji Kwak1,2,3, Wha Young Kim1, Jeong-Hoon Kim1,2
ORCID iDs: Jeong-Hoon Kim
  1. Department of Physiology, Yonsei University College of Medicine,Seoul, 03722 Republic of Korea
  2. Department of Medical Sciences, Yonsei University College of Medicine,Seoul, 03722 Republic of Korea
  3. Present Address: Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai,New York, NY 10029 USA
Institutions: Yonsei University (South Korea); Icahn School of Medicine at Mount Sinai (United States)
Journal: Translational psychiatry, volume 16, issue 1, article 245
Dates: received 22 June 2025; accepted 24 March 2026; published online 3 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41398-026-04015-4 · PMID 41932904 · PMCID PMC13171869 · OpenAlex W7148711274
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: rat (organism), other condition (population)
Methods: Statistics
Keywords: Addiction, Physiology
MeSH: Behavior, Animal*, Cocaine*, Decision Making*, Dopamine Uptake Inhibitors*, Gambling*, Nucleus Accumbens*, Prefrontal Cortex*, Risk-Taking*, Animals, Calcium Channels, L-Type, Chemogenetics, Dopamine and cAMP-Regulated Phosphoprotein 32, Male, Neural Pathways, Rats (* major topic)
Topic: Neurotransmitter Receptor Influence on Behavior (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: National Research Foundation of Korea (RS-2025-00563430, RS-2025-24873007, 2022R1A4A5033852)
Citations: not cited yet (Europe PMC); 54 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Code availability statement

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  • it says that the code is available on request

Read it in the paper: doi.org/10.1038/s41398-026-04015-4.

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Data

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Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 2 keywords, 15 MeSH terms, 1 funder, 54 references.

Cite

This paper

Han, J., Kwak, M. J., Kim, W. Y., & Kim, J.-H. (2026). Chemogenetic modulation of the prelimbic cortex to the nucleus accumbens core pathway reduces cocaine-induced increase of risk preference. Translational psychiatry, 16(1), 245. https://doi.org/10.1038/s41398-026-04015-4

BibTeX

@article{han2026chemogenetic,
author = {Han, Joonyeup and Kwak, Myung Ji and Kim, Wha Young and Kim, Jeong-Hoon},
title = {{Chemogenetic modulation of the prelimbic cortex to the nucleus accumbens core pathway reduces cocaine-induced increase of risk preference}},
journal = {Translational psychiatry},
year = {2026},
month = apr,
volume = {16},
number = {1},
pages = {245},
publisher = {Nature Publishing Group},
issn = {2158-3188},
doi = {10.1038/s41398-026-04015-4},
url = {https://doi.org/10.1038/s41398-026-04015-4},
pmid = {41932904},
pmcid = {PMC13171869}
}

RIS

TY - JOUR
AU - Han, Joonyeup
AU - Kwak, Myung Ji
AU - Kim, Wha Young
AU - Kim, Jeong-Hoon
TI - Chemogenetic modulation of the prelimbic cortex to the nucleus accumbens core pathway reduces cocaine-induced increase of risk preference
T2 - Translational psychiatry
J2 - Transl Psychiatry
PY - 2026
DA - 2026/04/03
VL - 16
IS - 1
SP - 245
SN - 2158-3188
PB - Nature Publishing Group
DO - 10.1038/s41398-026-04015-4
UR - https://doi.org/10.1038/s41398-026-04015-4
LA - en
ER -

CSL-JSON

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"author": [
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"ISSN": "2158-3188",
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"language": "en",
"issued": {
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