A depression-like phenotype is associated with discrete defects in the primary hippocampal circuit.
Overview
- Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697 USA
- Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 USA
- Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697 USA
Abstract
Major depressive disorder is known to disturb the hippocampus, but how this impacts signal processing performed by the structure remains poorly understood. Here, we report that single housing (7-10 days) promotes a depression-like phenotype in young adult mice that is associated with a robust, yet surprisingly discreet defect in information flow across the primary hippocampal circuit. In addition to sociability disturbances and despair-like behavior, single housing eliminated preference for novelty and impaired episodic memory encoding. Additionally, the lateral habenula, an epithalamic structure critically involved in depression, was hyperactive. Although the CA1 waveform and associated spike output elicited by single-pulse lateral perforant path (LPP) activation of hippocampus was largely unaffected by single housing, pronounced disturbances emerged when the circuit was activated with physiologically relevant frequencies and patterns. The characteristic ‘theta/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data and code for electrophysiological analysis are available upon reasonable request.
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Versions
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 2 keywords, 15 MeSH terms, 8 funders, 119 references.
Cite
This paper
Gunn, B. G., Yang, C. C., Lauterborn, J. C., Pruess, B. S., Quintanilla, J., Ge, K., Gall, C. M., & Lynch, G. (2026). A depression-like phenotype is associated with discrete defects in the primary hippocampal circuit. Translational psychiatry, 16(1), 350. https://
BibTeX
@article{gunn2026depress
author = {Gunn, Benjamin G and Yang, Chenyi C and Lauterborn, Julie C and Pruess, Benedict S and Quintanilla, Julian and Ge, Katelyn and Gall, Christine M and Lynch, Gary},
title = {{A depression-like phenotype is associated with discrete defects in the primary hippocampal circuit}},
journal = {Translational psychiatry},
year = {2026},
month = may,
volume = {16},
number = {1},
pages = {350},
publisher = {Nature Publishing Group},
issn = {2158-3188},
doi = {10.1038/
url = {https://
pmid = {42143033},
pmcid = {PMC13346759}
}
RIS
TY - JOUR
AU - Gunn, Benjamin G
AU - Yang, Chenyi C
AU - Lauterborn, Julie C
AU - Pruess, Benedict S
AU - Quintanilla, Julian
AU - Ge, Katelyn
AU - Gall, Christine M
AU - Lynch, Gary
TI - A depression-like phenotype is associated with discrete defects in the primary hippocampal circuit
T2 - Translational psychiatry
J2 - Transl Psychiatry
PY - 2026
DA - 2026/
VL - 16
IS - 1
SP - 350
SN - 2158-3188
PB - Nature Publishing Group
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
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