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Integrative epigenomic landscape of Alzheimer's Disease brains reveals oligodendrocyte molecular perturbations associated with tau.

Overview

Authors: Stephanie R Oatman1, Joseph S Reddy2, Amin Atashgaran1, Xue Wang2, Yuhao Min1, Zachary Quicksall2, Floor Vanelderen1, Minerva M Carrasquillo1, Chia-Chen Liu1, Yu Yamazaki1, Thuy T Nguyen1, Michael Heckman2, Na Zhao1, Michael DeTure1, Melissa E Murray1, Guojun Bu1, Takahisa Kanekiyo1, Dennis W Dickson1, Mariet Allen1, Nilüfer Ertekin-Taner1,3
ORCID iDs: Joseph S Reddy, Amin Atashgaran, Xue Wang, Yuhao Min, Zachary Quicksall, Floor Vanelderen, Minerva M Carrasquillo, Yu Yamazaki, Thuy T Nguyen, Na Zhao, Melissa E Murray, Guojun Bu, Takahisa Kanekiyo, Dennis W Dickson, Mariet Allen, Nilüfer Ertekin-Taner
  1. Department of Neuroscience, Mayo Clinic, Jacksonville, FL USA
  2. Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL USA
  3. Department of Neurology, Mayo Clinic, Jacksonville, FL USA
Institutions: Mayo Clinic in Florida (United States); Mayo Clinic (United States)
Journal: Nature communications, volume 17, issue 1, article 2116
Dates: received 19 February 2025; accepted 16 January 2026; published online 3 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-68864-9 · PMID 41775686 · PMCID PMC12957399 · OpenAlex W7133360275
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: genetics / omics (modality), human (organism), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Preprocessing, Connectivity
Keywords: Alzheimer's disease, DNA methylation, Epigenomics, Gene expression
MeSH: Alzheimer Disease*, Brain*, Oligodendroglia*, tau Proteins*, Adaptor Proteins, Signal Transducing, Aged, Aged, 80 and over, DNA Methylation, Epigenesis, Genetic, Epigenome, Epigenomics, Female, Genome-Wide Association Study, Humans, Male, Nuclear Proteins, Tauopathies, Transcriptome, Tumor Suppressor Proteins (* major topic)
Topic: Alzheimer's disease research and treatments (Physiology, Medicine), according to OpenAlex
Funding: NIA NIH HHS (R01 AG061796, U01 AG046139, RF1 AG051504, U19 AG074879, U01 AG006786); U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) (R37AG027924, P50AG016574)
Citations: cited by 8 papers (Europe PMC); 167 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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synapse.org/synapse:syn64465911

License: none: the authors keep all their rights
State: the link answers, verified on 30 September 2026
Evidence: the link answers
Software Heritage: not checked
Found in: “Code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 30 September 2026: the link answers (HTTP 200)
  • 30 September 2026: the link answers (HTTP 200)
At the source: synapse.org/Synapse:syn64465911

Code availability statement

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-68864-9.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 20 authors, 4 keywords, 19 MeSH terms, 2 funders, 165 references.

Cite

This paper

Oatman, S. R., Reddy, J. S., Atashgaran, A., Wang, X., Min, Y., Quicksall, Z., Vanelderen, F., Carrasquillo, M. M., Liu, C.-C., Yamazaki, Y., Nguyen, T. T., Heckman, M., Zhao, N., DeTure, M., Murray, M. E., Bu, G., Kanekiyo, T., Dickson, D. W., Allen, M., & Ertekin-Taner, N. (2026). Integrative epigenomic landscape of Alzheimer's Disease brains reveals oligodendrocyte molecular perturbations associated with tau. Nature communications, 17(1), 2116. https://doi.org/10.1038/s41467-026-68864-9

BibTeX

@article{oatman2026integrative,
author = {Oatman, Stephanie R and Reddy, Joseph S and Atashgaran, Amin and Wang, Xue and Min, Yuhao and Quicksall, Zachary and Vanelderen, Floor and Carrasquillo, Minerva M and Liu, Chia-Chen and Yamazaki, Yu and Nguyen, Thuy T and Heckman, Michael and Zhao, Na and DeTure, Michael and Murray, Melissa E and Bu, Guojun and Kanekiyo, Takahisa and Dickson, Dennis W and Allen, Mariet and Ertekin-Taner, Nilüfer},
title = {{Integrative epigenomic landscape of Alzheimer's Disease brains reveals oligodendrocyte molecular perturbations associated with tau}},
journal = {Nature communications},
year = {2026},
month = mar,
volume = {17},
number = {1},
pages = {2116},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-68864-9},
url = {https://doi.org/10.1038/s41467-026-68864-9},
pmid = {41775686},
pmcid = {PMC12957399}
}

RIS

TY - JOUR
AU - Oatman, Stephanie R
AU - Reddy, Joseph S
AU - Atashgaran, Amin
AU - Wang, Xue
AU - Min, Yuhao
AU - Quicksall, Zachary
AU - Vanelderen, Floor
AU - Carrasquillo, Minerva M
AU - Liu, Chia-Chen
AU - Yamazaki, Yu
AU - Nguyen, Thuy T
AU - Heckman, Michael
AU - Zhao, Na
AU - DeTure, Michael
AU - Murray, Melissa E
AU - Bu, Guojun
AU - Kanekiyo, Takahisa
AU - Dickson, Dennis W
AU - Allen, Mariet
AU - Ertekin-Taner, Nilüfer
TI - Integrative epigenomic landscape of Alzheimer's Disease brains reveals oligodendrocyte molecular perturbations associated with tau
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/03/03
VL - 17
IS - 1
SP - 2116
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-68864-9
UR - https://doi.org/10.1038/s41467-026-68864-9
LA - en
ER -

CSL-JSON

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