NF-κB activation in astrocytes impairs wound healing after traumatic brain injury in male mice.
Overview
- Institute of Physiological Chemistry, Ulm University,Ulm, Germany
- Molecular and Translational Neuroscience, Department of Neurology, University Medical Center Ulm,Ulm, Germany
- Core Facility Small Animal Imaging (CF-SANI), Ulm University,Ulm, Germany
- Department of Brain Sciences, Hammersmith Hospital Campus, Imperial College London,London, UK
- Internal Medicine I, Center of Internal Medicine, University Medical Center Ulm,Ulm, Germany
- Institute of Clinical and Experimental Trauma Immunology, University Medical Center Ulm,Ulm, Germany
Abstract
Traumatic brain injury (TBI) is a complex condition in which multiple pathophysiological mechanisms influence the course of the disease. After the initial mechanical impact, neuroinflammatory reactions of glial cells along with infiltrating peripheral immune cells determine the overall clinical outcome. However, these secondary processes and their molecular determinants promoting either beneficial or detrimental consequences are not well-defined. Here, we show that TBI-mediated NF-κB activation in astrocytes impairs their homeostatic functions, amplifies the post-traumatic neuroimmune response and disturbs the multicellular CNS scar development in a male mouse model of TBI. Our results further demonstrate a specific deficit in the formation of the glial limitans border and establish that paracrine signaling pathways induced by NF-κB-activated astrocytes can prevent a beneficial restoration of the CNS integrity after TBI. These findings enhance our understanding on the NF-κB-mediated post-traumatic pathophysiology and provide information on future targeted therapies to improve TBI outcome.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- geo:GSE276182, at NCBI GEO; found in “Data availability”
Data availability
The authors declare that the data supporting this study are presented in the article and Supplementary information files. Source data are provided with this paper. RNA sequencing data generated in this study have been deposited in the GEO database under accession codes GSE276182 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 20 authors, 4 keywords, 10 MeSH terms, 1 funder, 110 references.
Cite
This paper
Hein, T. M., Nespoli, E., Hakani, M., Wendt, H., May, S. N., Jorzik, J., Yagdiran, D., Schlett, J. S., Tsesmelis, K., Tsesmelis, M., Prex, V., Mettang, M., Abaei, A., Rasche, V., Lattke, M., Oswald, F., Huber-Lang, M., Dimou, L., Wirth, T., & Baumann, B. (2026). NF-κB activation in astrocytes impairs wound healing after traumatic brain injury in male mice. Nature communications, 17(1), 2323. https://
BibTeX
@article{hein2026nf,
author = {Hein, Tabea M. and Nespoli, Ester and Hakani, Marsela and Wendt, Heinrich and May, Stephanie Nadine and Jorzik, Jasmin and Yagdiran, Duygu and Schlett, Judith S. and Tsesmelis, Konstantinos and Tsesmelis, Miltiadis and Prex, Vivien and Mettang, Melanie and Abaei, Alireza and Rasche, Volker and Lattke, Michael and Oswald, Franz and Huber-Lang, Markus and Dimou, Leda and Wirth, Thomas and Baumann, Bernd},
title = {{NF-κB activation in astrocytes impairs wound healing after traumatic brain injury in male mice}},
journal = {Nature communications},
year = {2026},
month = mar,
volume = {17},
number = {1},
pages = {2323},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/
url = {https://
pmid = {41792174},
pmcid = {PMC12976058}
}
RIS
TY - JOUR
AU - Hein, Tabea M.
AU - Nespoli, Ester
AU - Hakani, Marsela
AU - Wendt, Heinrich
AU - May, Stephanie Nadine
AU - Jorzik, Jasmin
AU - Yagdiran, Duygu
AU - Schlett, Judith S.
AU - Tsesmelis, Konstantinos
AU - Tsesmelis, Miltiadis
AU - Prex, Vivien
AU - Mettang, Melanie
AU - Abaei, Alireza
AU - Rasche, Volker
AU - Lattke, Michael
AU - Oswald, Franz
AU - Huber-Lang, Markus
AU - Dimou, Leda
AU - Wirth, Thomas
AU - Baumann, Bernd
TI - NF-κB activation in astrocytes impairs wound healing after traumatic brain injury in male mice
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/
VL - 17
IS - 1
SP - 2323
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
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"author": [
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"family": "Hein",
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