OSCR

Identification of altered immune landscape at single-cell resolution in NSCLC brain metastasis and its association with poor immune checkpoint inhibitor responses.

Overview

Authors: Menglin Bai1,2, Tianwen Yin1,3, Xiaohui Li1,4, Peiliang Wang1,5, Tianyu Lei6, Peng Jin1, Feng Li7, Hongbo Guo8, Xiaokang Guo8, Xiao Sun9, Yan Li10, Bingwen Zou11, Jinming Yu1, Chao Liu1,4, Feifei Teng1
ORCID iDs: Menglin Bai, Xiao Sun, Chao Liu, Feifei Teng
  1. Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong China
  2. Department of Radiation Oncology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong China
  3. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei China
  4. Department of Radiation Oncology, Peking University First Hospital, Beijing, China
  5. State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong China
  6. Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, Hubei China
  7. Department of Neurosurgery, Shandong Cancer Hospital and Institute, Shandong First Medical Unverisity and Shandong Academy of Medical Sciences, Jinan, Shandong China
  8. Department of Thoracic Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong China
  9. School of Chemistry and Pharmaceutical Engineering, Medical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong China
  10. Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong China
  11. Department of Radiation Oncology, West China Hospital of Sichuan University, Chengdu, Sichuan China
Institutions: Shandong University (China); Shandong Tumor Hospital (China); Qilu Hospital of Shandong University (China); Shandong First Medical University (China); Huazhong University of Science and Technology (China); Peking University First Hospital (China); First Affiliated Hospital of Guangzhou Medical University (China); State Key Laboratory of Respiratory Disease (China); Guangzhou Institute of Respiratory Health (China); Renmin Hospital of Wuhan University (China); West China Hospital of Sichuan University (China)
Journal: Nature communications, volume 17, issue 1, article 2370
Dates: received 11 March 2025; accepted 4 March 2026; published online 10 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-70715-6 · PMID 41807427 · PMCID PMC12979737 · OpenAlex W7134929379
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning
Keywords: Gene regulation in immune cells, Cancer, T cells, Tumour immunology, Immunotherapy
MeSH: Brain Neoplasms*, Carcinoma, Non-Small-Cell Lung*, Immune Checkpoint Inhibitors*, Lung Neoplasms*, Dendritic Cells, Gene Expression Regulation, Neoplastic, Humans, Lymphocytes, Tumor-Infiltrating, Single-Cell Analysis, Single-Cell Gene Expression Analysis, T-Lymphocytes, Tumor Microenvironment, Tumor-Associated Macrophages (* major topic)
Topic: Single-cell and spatial transcriptomics (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Beijing Science and Technology Innovation Medical Development Foundation; National Natural Science Foundation of China (82473296); China Postdoctoral Science Foundation; Natural Science Foundation of Shandong Province
Citations: cited by 4 papers (Europe PMC); 72 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

The paper's code and data availability statement is in the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41467-026-70715-6.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 15 authors, 5 keywords, 13 MeSH terms, 4 funders, 71 references.

Cite

This paper

Bai, M., Yin, T., Li, X., Wang, P., Lei, T., Jin, P., Li, F., Guo, H., Guo, X., Sun, X., Li, Y., Zou, B., Yu, J., Liu, C., & Teng, F. (2026). Identification of altered immune landscape at single-cell resolution in NSCLC brain metastasis and its association with poor immune checkpoint inhibitor responses. Nature communications, 17(1), 2370. https://doi.org/10.1038/s41467-026-70715-6

BibTeX

@article{bai2026identification,
author = {Bai, Menglin and Yin, Tianwen and Li, Xiaohui and Wang, Peiliang and Lei, Tianyu and Jin, Peng and Li, Feng and Guo, Hongbo and Guo, Xiaokang and Sun, Xiao and Li, Yan and Zou, Bingwen and Yu, Jinming and Liu, Chao and Teng, Feifei},
title = {{Identification of altered immune landscape at single-cell resolution in NSCLC brain metastasis and its association with poor immune checkpoint inhibitor responses}},
journal = {Nature communications},
year = {2026},
month = mar,
volume = {17},
number = {1},
pages = {2370},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-70715-6},
url = {https://doi.org/10.1038/s41467-026-70715-6},
pmid = {41807427},
pmcid = {PMC12979737}
}

RIS

TY - JOUR
AU - Bai, Menglin
AU - Yin, Tianwen
AU - Li, Xiaohui
AU - Wang, Peiliang
AU - Lei, Tianyu
AU - Jin, Peng
AU - Li, Feng
AU - Guo, Hongbo
AU - Guo, Xiaokang
AU - Sun, Xiao
AU - Li, Yan
AU - Zou, Bingwen
AU - Yu, Jinming
AU - Liu, Chao
AU - Teng, Feifei
TI - Identification of altered immune landscape at single-cell resolution in NSCLC brain metastasis and its association with poor immune checkpoint inhibitor responses
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/03/10
VL - 17
IS - 1
SP - 2370
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-70715-6
UR - https://doi.org/10.1038/s41467-026-70715-6
LA - en
ER -

CSL-JSON

{
"id": "10.1038/s41467-026-70715-6",
"type": "article-journal",
"title": "Identification of altered immune landscape at single-cell resolution in NSCLC brain metastasis and its association with poor immune checkpoint inhibitor responses",
"container-title": "Nature communications",
"author": [
{
"family": "Bai",
"given": "Menglin"
},
{
"family": "Yin",
"given": "Tianwen"
},
{
"family": "Li",
"given": "Xiaohui"
},
{
"family": "Wang",
"given": "Peiliang"
},
{
"family": "Lei",
"given": "Tianyu"
},
{
"family": "Jin",
"given": "Peng"
},
{
"family": "Li",
"given": "Feng"
},
{
"family": "Guo",
"given": "Hongbo"
},
{
"family": "Guo",
"given": "Xiaokang"
},
{
"family": "Sun",
"given": "Xiao"
},
{
"family": "Li",
"given": "Yan"
},
{
"family": "Zou",
"given": "Bingwen"
},
{
"family": "Yu",
"given": "Jinming"
},
{
"family": "Liu",
"given": "Chao"
},
{
"family": "Teng",
"given": "Feifei"
}
],
"container-title-short": "Nat Commun",
"volume": "17",
"issue": "1",
"page": "2370",
"DOI": "10.1038/s41467-026-70715-6",
"PMID": "41807427",
"PMCID": "PMC12979737",
"ISSN": "2041-1723",
"publisher": "Nature Publishing Group",
"URL": "https://doi.org/10.1038/s41467-026-70715-6",
"language": "en",
"issued": {
"date-parts": [
[
2026,
3,
10
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1186/s12967-026-08447-w
Single-cell and spatial transcriptomes reveal oligodendrocyte remodeling fatty acid metabolism microenvironment of lung cancer brain metastases.
Journal: Journal of translational medicine
In common: NCBI GEO GSE131907, other condition, cellular / molecular, 5 references
[2] doi:10.1172/jci.insight.199498
Distinct immune landscapes characterize highly versus minimally invasive brain metastases.
Journal: JCI insight
In common: other condition, 5 references
[3] doi:10.1038/s41419-026-08807-w [code]
Single-cell profiling reveals distinct populations of tumor-associated macrophages and metastatic tumor cells in breast cancer brain metastasis.
Journal: Cell death & disease
In common: other condition, cellular / molecular, 5 references
[4] doi:10.21037/tcr-2026-1-0228
Phagocytic remodeling in CD74<sup>High</sup> tumor-associated macrophages during brain metastasis of lung adenocarcinoma.
Journal: Translational cancer research
In common: NCBI GEO GSE131907, other condition, 2 references
[5] doi:10.1038/s42003-026-10382-x [code]
ScQCenrich enables multi-metric quality control for single-cell RNA sequencing.
Journal: Communications biology
In common: NCBI GEO GSE131907, cellular / molecular, 2 references
[6] doi:10.3389/fcell.2026.1738641
Integrative single-cell and bulk RNA sequencing unravels the role of ACTN1 in promoting lung cancer with brain metastasis and epidermal growth factor receptor-tyrosine kinase inhibitor resistance.
Journal: Frontiers in cell and developmental biology
In common: other condition, cellular / molecular, 5 references
[7] doi:10.1007/s12672-026-05341-1
Single-cell data analysis of lung cancer brain metastasis reveals SEC61G serves as a potential risk indicator.
Journal: Discover oncology
In common: NCBI GEO GSE131907, other condition, cellular / molecular, 1 reference
[8] doi:10.1016/j.xcrm.2026.102766 [code]
A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma.
Journal: Cell reports. Medicine
In common: other condition, cellular / molecular, 5 references
[9] doi:10.1016/j.isci.2026.116517 [code]
Spatially resolved transcriptomics in human brain metastases identifies macrophage-tumor interactions associated with survival.
Journal: iScience
In common: other condition, 4 references
[10] doi:10.1038/s42003-026-09915-1
Single cell and spatial sequencing analysis of cancer associated fibroblasts in the brain metastasis tumor microenvironment.
Journal: Communications biology
In common: other condition, cellular / molecular, 4 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.