OSCR

RFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy.

Overview

Authors: Min Mao1,2, Hang Ji3, Wen-Qian Yu4, Qu-Jing Gai5, Qiang Sun5, Qian Yan5, Sen-Lin Xu5, Meng-Li Zhu6, Mei-Hua Qu7, Han-Min Liu1,2, Jean-Philipe Hugnot6,8, Xi He9, Xin Wang4, Yan Wang5,6
ORCID iDs: Mei-Hua Qu, Han-Min Liu, Xin Wang, Yan Wang
  1. The Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University,Chengdu, PR China
  2. Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education,Chengdu, PR China
  3. Department of Neurosurgery, West China Hospital, Sichuan University,Chengdu, PR China
  4. Department of Epidemiology and Biostatistics, West China School of Public Health, West China Fourth Hospital, Sichuan University,Chengdu, PR China
  5. Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Army Medical University (Third Military Medical University),Chongqing, PR China
  6. Chongqing Advanced Pathology Research Institute, Jinfeng Laboratory,Chongqing, PR China
  7. Translational Medical Center, Department of Pulmonary and Critical Care Medicine, Weifang Second People’s Hospital,Weifang, PR China
  8. Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM,Montpellier, France
  9. Shapingba Hospital affiliated to Chongqing University,Chongqing, PR China
Institutions: Sichuan University (China); Southwest Hospital (China); Jinfeng Laboratory (China); Yueyang Second People's Hospital (China); Université de Montpellier (France); Chongqing University (China)
Journal: Nature communications, volume 17, issue 1, article 4348
Dates: received 9 June 2025; accepted 4 March 2026; published online 23 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-70798-1 · PMID 41872171 · PMCID PMC13172434 · OpenAlex W7140108331
Open access: gold, a free copy (OpenAlex)
Status: data only (how the code is found and verified)
Categories: human (organism), mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Evoked potentials
Keywords: CNS cancer, Cancer, Cancer therapeutic resistance
MeSH: Autophagy*, Beclin-1*, Brain Neoplasms*, Drug Resistance, Neoplasm*, Glioblastoma*, Protein Serine-Threonine Kinases*, Replication Protein C*, Temozolomide*, Animals, Antineoplastic Agents, Alkylating, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Humans, Mice, Phosphorylation (* major topic)
Topic: Autophagy in Disease and Therapy (Cell Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Key Research and Development Program of China(2022YFA1104303)
Citations: cited by 1 paper (Europe PMC); 34 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

Datasets cited

Code and data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-70798-1.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 3 keywords, 15 MeSH terms, 1 funder, 34 references.

Cite

This paper

Mao, M., Ji, H., Yu, W.-Q., Gai, Q.-J., Sun, Q., Yan, Q., Xu, S.-L., Zhu, M.-L., Qu, M.-H., Liu, H.-M., Hugnot, J.-P., He, X., Wang, X., & Wang, Y. (2026). RFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy. Nature communications, 17(1), 4348. https://doi.org/10.1038/s41467-026-70798-1

BibTeX

@article{mao2026rfc4,
author = {Mao, Min and Ji, Hang and Yu, Wen-Qian and Gai, Qu-Jing and Sun, Qiang and Yan, Qian and Xu, Sen-Lin and Zhu, Meng-Li and Qu, Mei-Hua and Liu, Han-Min and Hugnot, Jean-Philipe and He, Xi and Wang, Xin and Wang, Yan},
title = {{RFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy}},
journal = {Nature communications},
year = {2026},
month = mar,
volume = {17},
number = {1},
pages = {4348},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-70798-1},
url = {https://doi.org/10.1038/s41467-026-70798-1},
pmid = {41872171},
pmcid = {PMC13172434}
}

RIS

TY - JOUR
AU - Mao, Min
AU - Ji, Hang
AU - Yu, Wen-Qian
AU - Gai, Qu-Jing
AU - Sun, Qiang
AU - Yan, Qian
AU - Xu, Sen-Lin
AU - Zhu, Meng-Li
AU - Qu, Mei-Hua
AU - Liu, Han-Min
AU - Hugnot, Jean-Philipe
AU - He, Xi
AU - Wang, Xin
AU - Wang, Yan
TI - RFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/03/23
VL - 17
IS - 1
SP - 4348
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-70798-1
UR - https://doi.org/10.1038/s41467-026-70798-1
LA - en
ER -

CSL-JSON

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