OSCR

Asymmetric histone inheritance regulates olfactory stem cell fates during regeneration.

Overview

Authors: Binbin Ma1,2, Guanghui Yang1,2, Jonathan Yao2, Charles Wu2, Jean Pinckney Vega2, Gabriel Manske3,4, Saher Sue Hammoud4, Satrajit Sinha5, Abhyudai Singh6, Haiqing Zhao2, Xin Chen1,2
ORCID iDs: Guanghui Yang, Saher Sue Hammoud, Satrajit Sinha, Abhyudai Singh, Haiqing Zhao, Xin Chen
  1. Howard Hughes Medical Institute, Department of Biology, Johns Hopkins University, Baltimore, MD USA
  2. Department of Biology, Johns Hopkins University, Baltimore, MD USA
  3. Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI USA
  4. Department of Human Genetics, University of Michigan, Ann Arbor, MI USA
  5. Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, SUNY at Buffalo, Buffalo, NY USA
  6. Electrical & Computer Engineering, University of Delaware, Newark, DE USA
Institutions: Howard Hughes Medical Institute (United States); Johns Hopkins University (United States); University of Michigan (United States); University at Buffalo, State University of New York (United States); University of Delaware (United States)
Journal: Nature communications, volume 17, issue 1, article 4361
Dates: received 26 June 2025; accepted 11 March 2026; published online 23 March 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1038/s41467-026-70987-y · PMID 41872193 · PMCID PMC13172531 · OpenAlex W7140104348
Open access: gold, a free copy (OpenAlex)
Status: data only (how the code is found and verified)
Categories: mouse (organism), cellular / molecular (subfield)
Methods: Spectral & time-frequency, Statistics, Smoothing, state filtering, decompositions, Connectivity, Physiology & signal measures
Keywords: Neural stem cells, Epigenetics and behaviour, Epigenetic memory, Regeneration
MeSH: Adult Stem Cells*, Histones*, Olfactory Mucosa*, Regeneration*, Animals, Cell Differentiation, Cell Lineage, Female, Mice, Mice, Inbred C57BL, Trans-Activators (* major topic)
Topic: Olfactory and Sensory Function Studies (Sensory Systems, Neuroscience), according to OpenAlex
Funding: Howard Hughes Medical Institute; NIGMS NIH HHS (R35 GM148351); NIDCD NIH HHS (R01 DC016065)
Citations: not cited yet (Europe PMC); 66 references in the paper
Research resources: RRID:SCR_026440

Abstract

The olfactory epithelium possesses an adult stem cell population, the horizontal basal cells (HBCs), to permit lifelong tissue regeneration. Here, we show that HBCs exhibit asymmetric inheritance of histone H4 but not H2A-H2B during olfactory epithelium regeneration in mice. Primary HBC cultures further revealed asymmetric histone inheritance for H3 and H3.3. Upon mitotic exit, asymmetric histone inheritance correlates with asynchronous transcription re-initiation and differential enrichment of p63, a key transcription factor for HBC cell fate. Disruption of asymmetric histone inheritance abolishes these asymmetric cellular features and attenuates olfactory epithelium regeneration and smell behavior recovery. Single-cell RNA sequencing of paired HBC daughters in culture further supports asymmetric multilineage cell fate priming. Together, these findings reveal asymmetric histone inheritance in a mammalian adult stem cell lineage and highlight its biological significance in neural tissue regeneration and animal behavior.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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The paper's code and data availability statement is in the Data section.

Tracing map

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Data

Datasets cited

Data availability

The scRNA-seq dataset in this study was deposited to Gene Expression Omnibus under the accession code GSE286046 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE286046). Source data are provided with this paper. Additional materials and protocols supporting this study are available from the corresponding authors upon reasonable request. Source data are provided with this paper.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 4 keywords, 11 MeSH terms, 3 funders, 66 references, 1 RRID.

Cite

This paper

Ma, B., Yang, G., Yao, J., Wu, C., Vega, J. P., Manske, G., Hammoud, S. S., Sinha, S., Singh, A., Zhao, H., & Chen, X. (2026). Asymmetric histone inheritance regulates olfactory stem cell fates during regeneration. Nature communications, 17(1), 4361. https://doi.org/10.1038/s41467-026-70987-y

BibTeX

@article{ma2026asymmetric,
author = {Ma, Binbin and Yang, Guanghui and Yao, Jonathan and Wu, Charles and Vega, Jean Pinckney and Manske, Gabriel and Hammoud, Saher Sue and Sinha, Satrajit and Singh, Abhyudai and Zhao, Haiqing and Chen, Xin},
title = {{Asymmetric histone inheritance regulates olfactory stem cell fates during regeneration}},
journal = {Nature communications},
year = {2026},
month = mar,
volume = {17},
number = {1},
pages = {4361},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-70987-y},
url = {https://doi.org/10.1038/s41467-026-70987-y},
pmid = {41872193},
pmcid = {PMC13172531}
}

RIS

TY - JOUR
AU - Ma, Binbin
AU - Yang, Guanghui
AU - Yao, Jonathan
AU - Wu, Charles
AU - Vega, Jean Pinckney
AU - Manske, Gabriel
AU - Hammoud, Saher Sue
AU - Sinha, Satrajit
AU - Singh, Abhyudai
AU - Zhao, Haiqing
AU - Chen, Xin
TI - Asymmetric histone inheritance regulates olfactory stem cell fates during regeneration
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/03/23
VL - 17
IS - 1
SP - 4361
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-70987-y
UR - https://doi.org/10.1038/s41467-026-70987-y
LA - en
ER -

CSL-JSON

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