OSCR

Neurodegeneration in the olfactory system in Niemann Pick type C1 disease.

Overview

Authors: Maria Grazia Fioriello1, Donatella Lobraico1, Raffaella Pia Gatta1, Lucia Iannuzzi1, Nicola Quaranta1, Simona Lobasso1, Johannes Reisert2, Antonio Frigeri1, Michele Dibattista1
  1. Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari Aldo Moro, Bari, Italy
  2. Monell Chemical Senses Center, Philadelphia, PA, USA
Institutions: University of Bari Aldo Moro (Italy); Monell Chemical Senses Center (United States)
Journal: iScience, volume 29, issue 8, article 116945
Dates: received 14 January 2026; accepted 9 July 2026; published online 27 July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.isci.2026.116945 · PMID 42564822 · PMCID PMC13446202 · OpenAlex W4416773272
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: human (organism), mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Preprocessing
Keywords: Olfactory epithelium, Neurodegeneration, Sense of smell
Topic: Lysosomal Storage Disorders Research (Physiology, Medicine), according to OpenAlex
Funding: Puglia Region; Università degli Studi di Bari
Citations: not cited yet (Europe PMC); 115 references in the paper
Research resources: Rabbit anti-Cytokeratin 14 RRID:AB_2134831, Mouse anti-Tuj1 (βIII-tubulin) RRID:AB_2313773, Alexa Fluor 488 goat anti-rabbit RRID:AB_2338050, Alexa Fluor 488 rabbit anti-mouse RRID:AB_2340210, Alexa Fluor 594 donkey anti-goat RRID:AB_2340432, Rabbit anti-cleaved Caspase-3 RRID:AB_2341188, Alexa Fluor 555 donkey anti-rabbit RRID:AB_3095471, Rabbit anti-Ki67 RRID:AB_443209, Goat anti-OMP RRID:AB_664696, Rabbit anti-Iba1 RRID:AB_839504, B6.129-Npc1tm(I1061T)Dso mice RRID:IMSR_JAX:027704, PatchMaster RRID:SCR_000034, Igor Pro 8 software RRID:SCR_000325, ImageJ RRID:SCR_003070, Lipid Maps Database RRID:SCR_003817, Python RRID:SCR_008394, ClinProTools RRID:SCR_014341, Inkscape RRID:SCR_014479, Visual Studio Code RRID:SCR_026031

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

The paper's code and data availability statement is in the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.

Data

No dataset and no data link were found in the paper.

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the data are available on request
  • it says that the code is available on request

Read it in the paper: doi.org/10.1016/j.isci.2026.116945.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Authors: added Donatella Lobraico (0000-0002-9595-2121); Simona Lobasso (0000-0003-3566-4547); Johannes Reisert (0000-0002-9393-9257); Michele Dibattista (0000-0002-3955-4663); removed Donatella Lobraico; Simona Lobasso; Johannes Reisert; Michele Dibattista

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 3 keywords, 2 funders, 114 references, 19 RRIDs.

Cite

This paper

Fioriello, M. G., Lobraico, D., Gatta, R. P., Iannuzzi, L., Quaranta, N., Lobasso, S., Reisert, J., Frigeri, A., & Dibattista, M. (2026). Neurodegeneration in the olfactory system in Niemann Pick type C1 disease. iScience, 29(8), 116945. https://doi.org/10.1016/j.isci.2026.116945

BibTeX

@article{fioriello2026neurodegeneration,
author = {Fioriello, Maria Grazia and Lobraico, Donatella and Gatta, Raffaella Pia and Iannuzzi, Lucia and Quaranta, Nicola and Lobasso, Simona and Reisert, Johannes and Frigeri, Antonio and Dibattista, Michele},
title = {{Neurodegeneration in the olfactory system in Niemann Pick type C1 disease}},
journal = {iScience},
year = {2026},
month = jul,
volume = {29},
number = {8},
pages = {116945},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.116945},
url = {https://doi.org/10.1016/j.isci.2026.116945},
pmid = {42564822},
pmcid = {PMC13446202}
}

RIS

TY - JOUR
AU - Fioriello, Maria Grazia
AU - Lobraico, Donatella
AU - Gatta, Raffaella Pia
AU - Iannuzzi, Lucia
AU - Quaranta, Nicola
AU - Lobasso, Simona
AU - Reisert, Johannes
AU - Frigeri, Antonio
AU - Dibattista, Michele
TI - Neurodegeneration in the olfactory system in Niemann Pick type C1 disease
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/07/27
VL - 29
IS - 8
SP - 116945
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.116945
UR - https://doi.org/10.1016/j.isci.2026.116945
LA - en
ER -

CSL-JSON

{
"id": "10.1016/j.isci.2026.116945",
"type": "article-journal",
"title": "Neurodegeneration in the olfactory system in Niemann Pick type C1 disease",
"container-title": "iScience",
"author": [
{
"family": "Fioriello",
"given": "Maria Grazia"
},
{
"family": "Lobraico",
"given": "Donatella"
},
{
"family": "Gatta",
"given": "Raffaella Pia"
},
{
"family": "Iannuzzi",
"given": "Lucia"
},
{
"family": "Quaranta",
"given": "Nicola"
},
{
"family": "Lobasso",
"given": "Simona"
},
{
"family": "Reisert",
"given": "Johannes"
},
{
"family": "Frigeri",
"given": "Antonio"
},
{
"family": "Dibattista",
"given": "Michele"
}
],
"container-title-short": "iScience",
"volume": "29",
"issue": "8",
"page": "116945",
"DOI": "10.1016/j.isci.2026.116945",
"PMID": "42564822",
"PMCID": "PMC13446202",
"ISSN": "2589-0042",
"publisher": "Elsevier",
"URL": "https://doi.org/10.1016/j.isci.2026.116945",
"language": "en",
"issued": {
"date-parts": [
[
2026,
7,
27
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1038/s41598-026-51082-0
Non-uniform endogenous regeneration of olfactory sensory neuron axons across the mouse olfactory bulb.
Journal: Scientific reports
In common: mouse, 6 references
[2] doi:10.1016/j.isci.2026.116121 [code]
Multi-omics reveal phosphatidic acid phosphatases modify Niemann-Pick type C disease severity.
Journal: iScience
In common: mouse, 5 references
[3] doi:10.1038/s41467-026-75722-1 [code]
Single-nucleus analysis of the adult human olfactory epithelium uncovers shared neurogenesis programs with the brain.
Journal: Nature communications
In common: 3 references
[4] doi:10.1002/glia.70163
A Cross-Disease Microglial Transcriptional Program Characterizes Neurodegeneration and Highlights SPP1 as a Biomarker.
Journal: Glia
In common: other condition, mouse, cellular / molecular, 2 references
[5] doi:10.1162/imag.a.1191
Robust functional ultrasound imaging in the awake and behaving brain: A systematic framework for motion artifact removal.
Journal: Imaging neuroscience (Cambridge, Mass.)
In common: mouse, 4 references
[6] doi:10.1073/pnas.2619797123 [code]
Selective loss of primary cilia and neurotrophic signaling in G51D α-synuclein mice highlights a common pathway to Parkinson's disease.
Journal: Proceedings of the National Academy of Sciences of the United States of America
In common: mouse, cellular / molecular, 3 references
[7] doi:10.1371/journal.pbio.3003856 [code]
Aging and metabolism contribute separately to brain-body health.
Journal: PLoS biology
In common: 4 references
[8] doi:10.1016/j.neuron.2026.05.004 [code]
A learning-evoked slow-oscillatory architecture paces population activity for offline reactivation across the human medial temporal lobe.
Journal: Neuron
In common: 4 references
[9] doi:10.1016/j.isci.2026.117375 [code]
Motor priming is associated with widespread recruitment into neural ensembles and more rapid ensemble transitions.
Journal: iScience
In common: 4 references
[10] doi:10.1371/journal.pcbi.1013441 [code]
Large vision model framework for automated C. elegans analysis: From static morphometry to dynamic neural activity.
Journal: PLoS computational biology
In common: 4 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.