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Transport and inhibition mechanisms of human glycine transporter 2.

Overview

Authors: Wenming Ji1, Yuanzhi Yu1, Zirui Liu2, Junwen Su2, Qianyu Wang1, Mulin Lai2, Jing-Xiang Wu1
  1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing, PR China
  2. School of Clinical Pharmacy, Shenyang Pharmaceutical University,Shenyang, PR China
Journal: Nature communications, volume 17, issue 1, article 5321
Dates: received 15 September 2025; accepted 3 April 2026; published online 16 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-71935-6 · PMID 41991951 · PMCID PMC13273173 · OpenAlex W7154562590
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: histology / microscopy (modality), human (organism), pain (population), cellular / molecular (subfield)
Methods: Statistics, Evoked potentials
Keywords: Cryoelectron microscopy, Transporters in the nervous system, Pain, Neurological disorders
MeSH: Glycine Plasma Membrane Transport Proteins*, Allosteric Site, Benzamides, Biological Transport, Glycine, Humans, Models, Molecular, Protein Conformation (* major topic)
Topic: Amino Acid Enzymes and Metabolism (Biochemistry, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (National Science Foundation of China) (32522046, 32371266); CAMS Innovation Fund for Medical Sciences (CIFMS) (2023-I2M-2-006 and 2025-I2M-QN-005), the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2022-RC350-01), Scientific Research Innovation Capability Support Project for Young Faculty (ZYGXQNJSKYCXNLZCXM-B2)
Citations: not cited yet (Europe PMC); 55 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Code and data availability statement

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Versions

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Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 4 keywords, 8 MeSH terms, 2 funders, 55 references.

Cite

This paper

Ji, W., Yu, Y., Liu, Z., Su, J., Wang, Q., Lai, M., & Wu, J.-X. (2026). Transport and inhibition mechanisms of human glycine transporter 2. Nature communications, 17(1), 5321. https://doi.org/10.1038/s41467-026-71935-6

BibTeX

@article{ji2026transport,
author = {Ji, Wenming and Yu, Yuanzhi and Liu, Zirui and Su, Junwen and Wang, Qianyu and Lai, Mulin and Wu, Jing-Xiang},
title = {{Transport and inhibition mechanisms of human glycine transporter 2}},
journal = {Nature communications},
year = {2026},
month = apr,
volume = {17},
number = {1},
pages = {5321},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-71935-6},
url = {https://doi.org/10.1038/s41467-026-71935-6},
pmid = {41991951},
pmcid = {PMC13273173}
}

RIS

TY - JOUR
AU - Ji, Wenming
AU - Yu, Yuanzhi
AU - Liu, Zirui
AU - Su, Junwen
AU - Wang, Qianyu
AU - Lai, Mulin
AU - Wu, Jing-Xiang
TI - Transport and inhibition mechanisms of human glycine transporter 2
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/04/16
VL - 17
IS - 1
SP - 5321
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-71935-6
UR - https://doi.org/10.1038/s41467-026-71935-6
LA - en
ER -

CSL-JSON

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