OSCR

Structural origins of species-specific differences in TRPV2 activation.

Overview

Authors: Tabea C Fricke1, Ruth A Pumroy2,3, Julia A Rocereta2,3, José J De Jesús-Pérez2,3, George Oprita4,5, Marvin J A Meyer1, Christine Herzog1, Frank G Echtermeyer1, Kerstin Hill6, Andreas Leffler1, Vera Y Moiseenkova-Bell2,3
ORCID iDs: Ruth A Pumroy, Julia A Rocereta, George Oprita, Marvin J A Meyer, Kerstin Hill, Andreas Leffler, Vera Y Moiseenkova-Bell
  1. Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany
  2. Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
  3. Institute of Structural Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
  4. Department of Anatomy, Physiology, and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania
  5. National Center for Brain Research, Research Institute for Artificial Intelligence, Romanian Academy, Bucharest, Romania
  6. Rudolf Boehm Institute of Pharmacology and Toxicology, Leipzig University, Leipzig, Germany
Institutions: Medizinische Hochschule Hannover (Germany); University of Pennsylvania (United States); University of Bucharest (Romania); Romanian Academy (Romania); Leipzig University (Germany)
Journal: Nature communications, volume 17, issue 1, article 8737
Dates: received 9 March 2026; accepted 3 August 2026; published online 20 August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-76831-7 · PMID 42624855 · PMCID PMC13494035 · OpenAlex W7203837340
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: histology / microscopy (modality), intracellular / patch clamp (modality), human (organism), mouse (organism), rat (organism), cellular / molecular (subfield)
Methods: Statistics
Keywords: Cryoelectron microscopy, Transient receptor potential channels, Patch clamp
MeSH: Calcium Channels*, TRPV Cation Channels*, Animals, Binding Sites, Boron Compounds, Cryoelectron Microscopy, HEK293 Cells, Humans, Mice, Models, Molecular, Mutation, Protein Domains, Rats, Species Specificity (* major topic)
Topic: Ion Channels and Receptors (Sensory Systems, Neuroscience), according to OpenAlex
Funding: U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) (R35GM144120); NIGMS NIH HHS (R35 GM144120)
Citations: not cited yet (Europe PMC); 71 references in the paper
Research resources: RRID:SCR_022375

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

Datasets cited

Code and data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-76831-7.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 3 keywords, 14 MeSH terms, 2 funders, 66 references, 1 RRID.

Cite

This paper

Fricke, T. C., Pumroy, R. A., Rocereta, J. A., De Jesús-Pérez, J. J., Oprita, G., Meyer, M. J. A., Herzog, C., Echtermeyer, F. G., Hill, K., Leffler, A., & Moiseenkova-Bell, V. Y. (2026). Structural origins of species-specific differences in TRPV2 activation. Nature communications, 17(1), 8737. https://doi.org/10.1038/s41467-026-76831-7

BibTeX

@article{fricke2026structural,
author = {Fricke, Tabea C and Pumroy, Ruth A and Rocereta, Julia A and De Jesús-Pérez, José J and Oprita, George and Meyer, Marvin J A and Herzog, Christine and Echtermeyer, Frank G and Hill, Kerstin and Leffler, Andreas and Moiseenkova-Bell, Vera Y},
title = {{Structural origins of species-specific differences in TRPV2 activation}},
journal = {Nature communications},
year = {2026},
month = aug,
volume = {17},
number = {1},
pages = {8737},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-76831-7},
url = {https://doi.org/10.1038/s41467-026-76831-7},
pmid = {42624855},
pmcid = {PMC13494035}
}

RIS

TY - JOUR
AU - Fricke, Tabea C
AU - Pumroy, Ruth A
AU - Rocereta, Julia A
AU - De Jesús-Pérez, José J
AU - Oprita, George
AU - Meyer, Marvin J A
AU - Herzog, Christine
AU - Echtermeyer, Frank G
AU - Hill, Kerstin
AU - Leffler, Andreas
AU - Moiseenkova-Bell, Vera Y
TI - Structural origins of species-specific differences in TRPV2 activation
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/08/20
VL - 17
IS - 1
SP - 8737
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-76831-7
UR - https://doi.org/10.1038/s41467-026-76831-7
LA - en
ER -

CSL-JSON

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