OSCR

Engineered BCG selectively triggers trained immunity in tumor-associated macrophages and sensitizes glioblastoma to radiotherapy in mice.

Overview

Authors: Ke Ren1, Ziyang Yuan2, Lei Lei2, Ziyuan Xiao2, Ningyi Ma2, Guodong Wang1, Ningyi Sun1, Tai Yang3, Zhiyong Chang4, Liang Qin4, Ying Xu5, Dahai Yu4, Lizhou Jia6, Haishi Qiao2
ORCID iDs: Ke Ren, Ziyang Yuan, Tai Yang, Dahai Yu, Lizhou Jia, Haishi Qiao
  1. Department of Clinical Microbiology, School of Laboratory Medicine, Chengdu Medical College, Chengdu, China
  2. Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, China
  3. School of Pharmacy, Chengdu Medical College, Chengdu, China
  4. Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China
  5. The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
  6. Central Laboratory, Bayannur Hospital, Bayannur, China
Institutions: Chengdu Medical College (China); China Pharmaceutical University (China); Nanjing University of Chinese Medicine (China); First Affiliated Hospital of Chengdu Medical College (China)
Journal: Nature communications, volume 17, issue 1, article 5465
Dates: received 22 November 2024; accepted 2 April 2026; published online 20 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-72067-7 · PMID 42009673 · PMCID PMC13284352 · OpenAlex W7155000913
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), other condition (population)
Methods: Spectral & time-frequency, Statistics, Evoked potentials, Connectivity, fMRI & imaging
Keywords: Biotechnology, Tumour immunology, Radiotherapy
MeSH: BCG Vaccine*, Brain Neoplasms*, Glioblastoma*, Mycobacterium bovis*, Tumor-Associated Macrophages*, Animals, CD8-Positive T-Lymphocytes, Cell Line, Tumor, Female, Humans, Macrophages, Mice, Mice, Inbred C57BL, Phagocytosis, Reactive Oxygen Species, Trained Immunity (* major topic)
Topic: Immune responses and vaccinations (Immunology, Immunology and Microbiology), according to OpenAlex
Funding: China Postdoctoral Science Foundation (2021M693953)
Citations: cited by 1 paper (Europe PMC); 50 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-72067-7.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 3 keywords, 16 MeSH terms, 1 funder, 48 references.

Cite

This paper

Ren, K., Yuan, Z., Lei, L., Xiao, Z., Ma, N., Wang, G., Sun, N., Yang, T., Chang, Z., Qin, L., Xu, Y., Yu, D., Jia, L., & Qiao, H. (2026). Engineered BCG selectively triggers trained immunity in tumor-associated macrophages and sensitizes glioblastoma to radiotherapy in mice. Nature communications, 17(1), 5465. https://doi.org/10.1038/s41467-026-72067-7

BibTeX

@article{ren2026engineered,
author = {Ren, Ke and Yuan, Ziyang and Lei, Lei and Xiao, Ziyuan and Ma, Ningyi and Wang, Guodong and Sun, Ningyi and Yang, Tai and Chang, Zhiyong and Qin, Liang and Xu, Ying and Yu, Dahai and Jia, Lizhou and Qiao, Haishi},
title = {{Engineered BCG selectively triggers trained immunity in tumor-associated macrophages and sensitizes glioblastoma to radiotherapy in mice}},
journal = {Nature communications},
year = {2026},
month = apr,
volume = {17},
number = {1},
pages = {5465},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-72067-7},
url = {https://doi.org/10.1038/s41467-026-72067-7},
pmid = {42009673},
pmcid = {PMC13284352}
}

RIS

TY - JOUR
AU - Ren, Ke
AU - Yuan, Ziyang
AU - Lei, Lei
AU - Xiao, Ziyuan
AU - Ma, Ningyi
AU - Wang, Guodong
AU - Sun, Ningyi
AU - Yang, Tai
AU - Chang, Zhiyong
AU - Qin, Liang
AU - Xu, Ying
AU - Yu, Dahai
AU - Jia, Lizhou
AU - Qiao, Haishi
TI - Engineered BCG selectively triggers trained immunity in tumor-associated macrophages and sensitizes glioblastoma to radiotherapy in mice
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/04/20
VL - 17
IS - 1
SP - 5465
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-72067-7
UR - https://doi.org/10.1038/s41467-026-72067-7
LA - en
ER -

CSL-JSON

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