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Neuregulin-1 facilitates myelin regeneration through microglia-mediated mechanisms in a mouse model of chronic demyelination.

Overview

Authors: Seyyed Mohyeddin Ziaee1, Shiva Nemati1, Hardeep Kataria1, Elisabet Jakova1, Seyed Mojtaba Hosseini1, Pejman Ghelich2, Graham McLeod1, Ali Tamayol2, V. Wee Yong3, Soheila Karimi-Abdolrezaee1,4
ORCID iDs: Hardeep Kataria, Ali Tamayol, V. Wee Yong, Soheila Karimi-Abdolrezaee
  1. Department of Physiology and Pathophysiology, Manitoba Multiple Sclerosis Research Centre, Rady Faculty of Health Sciences, University of Manitoba,Winnipeg, MB Canada
  2. Department of Biomedical Engineering, University of Connecticut,Farmington, CT USA
  3. Hotchkiss Brain Institute and the Department of Clinical Neurosciences, University of Calgary,Calgary, AB Canada
  4. Children Hospital Research Institute of Manitoba,Winnipeg, MB Canada
Institutions: University of Manitoba (Canada); University of Connecticut (United States); University of Calgary (Canada); Children's Hospital Research Institute of Manitoba (Canada)
Journal: Nature communications, volume 17, issue 1, article 5584
Dates: received 18 November 2024; accepted 1 April 2026; published online 11 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-72639-7 · PMID 42115623 · PMCID PMC13309555 · OpenAlex W7160868225
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), multiple sclerosis (population), cellular / molecular (subfield)
Methods: Statistics, Spectral & time-frequency, Evoked potentials, fMRI & imaging
Keywords: Myelin biology and repair, Microglia, Multiple sclerosis
MeSH: Demyelinating Diseases*, Microglia*, Myelin Sheath*, Neuregulin-1*, Remyelination*, Animals, Cholesterol, Disease Models, Animal, Female, Male, Mice, Mice, Inbred C57BL, Multiple Sclerosis, Oligodendroglia, Phagocytosis, Signal Transduction (* major topic)
Topic: Neurogenesis and neuroplasticity mechanisms (Developmental Neuroscience, Neuroscience), according to OpenAlex
Funding: Multiple Sclerosis Society of Canada (Société Canadienne de la Sclérose en Plaques) (EGID3742 and 1241879); Canadian Institutes of Health Research (PJT-191850); Hillary Kaufman Memorial Funds in Multiple Sclerosis from the University of Manitoba
Citations: cited by 1 paper (Europe PMC); 125 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-72639-7.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 3 keywords, 16 MeSH terms, 3 funders, 125 references.

Cite

This paper

Ziaee, S. M., Nemati, S., Kataria, H., Jakova, E., Hosseini, S. M., Ghelich, P., McLeod, G., Tamayol, A., Yong, V. W., & Karimi-Abdolrezaee, S. (2026). Neuregulin-1 facilitates myelin regeneration through microglia-mediated mechanisms in a mouse model of chronic demyelination. Nature communications, 17(1), 5584. https://doi.org/10.1038/s41467-026-72639-7

BibTeX

@article{ziaee2026neuregulin,
author = {Ziaee, Seyyed Mohyeddin and Nemati, Shiva and Kataria, Hardeep and Jakova, Elisabet and Hosseini, Seyed Mojtaba and Ghelich, Pejman and McLeod, Graham and Tamayol, Ali and Yong, V. Wee and Karimi-Abdolrezaee, Soheila},
title = {{Neuregulin-1 facilitates myelin regeneration through microglia-mediated mechanisms in a mouse model of chronic demyelination}},
journal = {Nature communications},
year = {2026},
month = may,
volume = {17},
number = {1},
pages = {5584},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-72639-7},
url = {https://doi.org/10.1038/s41467-026-72639-7},
pmid = {42115623},
pmcid = {PMC13309555}
}

RIS

TY - JOUR
AU - Ziaee, Seyyed Mohyeddin
AU - Nemati, Shiva
AU - Kataria, Hardeep
AU - Jakova, Elisabet
AU - Hosseini, Seyed Mojtaba
AU - Ghelich, Pejman
AU - McLeod, Graham
AU - Tamayol, Ali
AU - Yong, V. Wee
AU - Karimi-Abdolrezaee, Soheila
TI - Neuregulin-1 facilitates myelin regeneration through microglia-mediated mechanisms in a mouse model of chronic demyelination
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/05/11
VL - 17
IS - 1
SP - 5584
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-72639-7
UR - https://doi.org/10.1038/s41467-026-72639-7
LA - en
ER -

CSL-JSON

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