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Endothelial cell-secreted SPARC suppresses astrocytic CD59 expression and promotes astrocytopathy in a mouse model of neuromyelitis optica spectrum disorders.

Overview

Authors: Tingting Cui1, Ye Gong1, Zhen Wang1, Pei Li1, Luhang Dai1, Jia Chen1, Zhe Feng1, Xueli Liu1, Shaogang Li1, Huanyi Liu1, Ke Li1, Xiaoli Ding1, Xiaochang Xue1, Luting Yang1, Lei Zhang1, Rui Li2,3, Ying Fu2,3, Yaling Zhang1, Yaping Yan1
ORCID iDs: Xiaochang Xue, Lei Zhang, Rui Li, Yaping Yan
  1. Key Laboratory for Medicinal Resources and Natural Pharmaceutical Chemistry, Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi’an, China
  2. Department of Neurology and Institute of Neurology of First Affiliated Hospital, Fujian Medical University, Fuzhou, China
  3. Fujian Key Laboratory of Molecular Neurology and Institute of Neuroscience, Fujian Medical University, Fuzhou, China
Institutions: Shaanxi Normal University (China); Fujian Medical University (China); First Affiliated Hospital of Fujian Medical University (China)
Journal: Nature communications, volume 17, issue 1, article 6348
Dates: received 24 May 2025; accepted 20 April 2026; published online 12 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-72997-2 · PMID 42120878 · PMCID PMC13377043 · OpenAlex W7160931707
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Spectral & time-frequency, Statistics
Keywords: Astrocyte, Autoimmune diseases, Demyelinating diseases
MeSH: Astrocytes*, CD59 Antigens*, Endothelial Cells*, Neuromyelitis Optica*, Osteonectin*, Animals, Aquaporin 4, Cell Proliferation, Disease Models, Animal, Female, Humans, Immunoglobulin G, Mice, Mice, Inbred C57BL, Signal Transduction, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor Receptor-2 (* major topic)
Topic: Bone and Dental Protein Studies (Rheumatology, Medicine), according to OpenAlex
Funding: Natural Science Foundation of Shaanxi Province (Shaanxi Province Natural Science Foundation) (2023-JC-JQ-64); National Natural Science Foundation of China (National Science Foundation of China) (82071348, 82471381, 82201493)
Citations: not cited yet (Europe PMC); 64 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-72997-2.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 19 authors, 3 keywords, 17 MeSH terms, 2 funders, 63 references.

Cite

This paper

Cui, T., Gong, Y., Wang, Z., Li, P., Dai, L., Chen, J., Feng, Z., Liu, X., Li, S., Liu, H., Li, K., Ding, X., Xue, X., Yang, L., Zhang, L., Li, R., Fu, Y., Zhang, Y., & Yan, Y. (2026). Endothelial cell-secreted SPARC suppresses astrocytic CD59 expression and promotes astrocytopathy in a mouse model of neuromyelitis optica spectrum disorders. Nature communications, 17(1), 6348. https://doi.org/10.1038/s41467-026-72997-2

BibTeX

@article{cui2026endothelial,
author = {Cui, Tingting and Gong, Ye and Wang, Zhen and Li, Pei and Dai, Luhang and Chen, Jia and Feng, Zhe and Liu, Xueli and Li, Shaogang and Liu, Huanyi and Li, Ke and Ding, Xiaoli and Xue, Xiaochang and Yang, Luting and Zhang, Lei and Li, Rui and Fu, Ying and Zhang, Yaling and Yan, Yaping},
title = {{Endothelial cell-secreted SPARC suppresses astrocytic CD59 expression and promotes astrocytopathy in a mouse model of neuromyelitis optica spectrum disorders}},
journal = {Nature communications},
year = {2026},
month = may,
volume = {17},
number = {1},
pages = {6348},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-72997-2},
url = {https://doi.org/10.1038/s41467-026-72997-2},
pmid = {42120878},
pmcid = {PMC13377043}
}

RIS

TY - JOUR
AU - Cui, Tingting
AU - Gong, Ye
AU - Wang, Zhen
AU - Li, Pei
AU - Dai, Luhang
AU - Chen, Jia
AU - Feng, Zhe
AU - Liu, Xueli
AU - Li, Shaogang
AU - Liu, Huanyi
AU - Li, Ke
AU - Ding, Xiaoli
AU - Xue, Xiaochang
AU - Yang, Luting
AU - Zhang, Lei
AU - Li, Rui
AU - Fu, Ying
AU - Zhang, Yaling
AU - Yan, Yaping
TI - Endothelial cell-secreted SPARC suppresses astrocytic CD59 expression and promotes astrocytopathy in a mouse model of neuromyelitis optica spectrum disorders
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/05/12
VL - 17
IS - 1
SP - 6348
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-72997-2
UR - https://doi.org/10.1038/s41467-026-72997-2
LA - en
ER -

CSL-JSON

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