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Cryo-EM structures of heteromeric Kir4.1/5.1 channel suggest mechanisms of inward rectification and channel blockage.

Overview

Authors: Yingjie Ning1,2, Xiaoyu Zhou3, Yimin Zhang4,5, Nanhao Chen6, Qianbei Guo3,7, Chenxia Gu1, Didi Xu1, Ran Cui1, Jiayi Wang1, Mengdan Li3,8, Dongxue Yang9, Chen Song6, Jie Yu4,10, Zhaobing Gao3,7,8, Jingpeng Ge1
ORCID iDs: Dongxue Yang, Chen Song, Jie Yu, Zhaobing Gao, Jingpeng Ge
  1. School of Life Science and Technology, ShanghaiTech University, Shanghai, China
  2. Lingang Laboratory, Shanghai, China
  3. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
  4. Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China
  5. University of Chinese Academy of Sciences, Beijing, China
  6. Center for Quantitative Biology, Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China
  7. School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai, China
  8. School of Pharmacy, Henan University, Kaifeng, China
  9. Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu, Sichuan China
  10. Shanghai Key Laboratory of Aging Studies, Shanghai, China
Institutions: ShanghaiTech University (China); Chinese Academy of Sciences (China); Shanghai Institute of Materia Medica (China); State Key Laboratory of Drug Research; Shanghai Institute of Organic Chemistry (China); University of Chinese Academy of Sciences (China); Peking University (China); Center for Life Sciences (China); Fudan University (China); Henan University (China); Sichuan University (China); West China Hospital of Sichuan University (China)
Journal: Nature communications, volume 17, issue 1, article 7216
Dates: received 9 May 2025; accepted 29 May 2026; published online 6 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-74087-9 · PMID 42248902 · PMCID PMC13396768 · OpenAlex W7163687910
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: histology / microscopy (modality), human (organism), cellular / molecular (subfield)
Methods: Statistics
Keywords: Ion channels in the nervous system, Cryoelectron microscopy, Structural biology
MeSH: Potassium Channels, Inwardly Rectifying*, Animals, Cryoelectron Microscopy, HEK293 Cells, Humans, Kcnj10 Channel, Molecular Dynamics Simulation, Potassium, Potassium Channel Blockers, Spermine (* major topic)
Topic: Nanopore and Nanochannel Transport Studies (Biomedical Engineering, Engineering), according to OpenAlex
Citations: cited by 2 papers (Europe PMC); 71 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

Zenodo 20374687

License: CC-BY-4.0
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Size: 1 file
Software Heritage: not checked
Found in: the references
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)
At the source:

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Read it in the paper: doi.org/10.1038/s41467-026-74087-9.

Tracing map

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Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41467-026-74087-9.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 15 authors, 3 keywords, 10 MeSH terms, 69 references.

Cite

This paper

Ning, Y., Zhou, X., Zhang, Y., Chen, N., Guo, Q., Gu, C., Xu, D., Cui, R., Wang, J., Li, M., Yang, D., Song, C., Yu, J., Gao, Z., & Ge, J. (2026). Cryo-EM structures of heteromeric Kir4.1/5.1 channel suggest mechanisms of inward rectification and channel blockage. Nature communications, 17(1), 7216. https://doi.org/10.1038/s41467-026-74087-9

BibTeX

@article{ning2026cryo,
author = {Ning, Yingjie and Zhou, Xiaoyu and Zhang, Yimin and Chen, Nanhao and Guo, Qianbei and Gu, Chenxia and Xu, Didi and Cui, Ran and Wang, Jiayi and Li, Mengdan and Yang, Dongxue and Song, Chen and Yu, Jie and Gao, Zhaobing and Ge, Jingpeng},
title = {{Cryo-EM structures of heteromeric Kir4.1/5.1 channel suggest mechanisms of inward rectification and channel blockage}},
journal = {Nature communications},
year = {2026},
month = jun,
volume = {17},
number = {1},
pages = {7216},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-74087-9},
url = {https://doi.org/10.1038/s41467-026-74087-9},
pmid = {42248902},
pmcid = {PMC13396768}
}

RIS

TY - JOUR
AU - Ning, Yingjie
AU - Zhou, Xiaoyu
AU - Zhang, Yimin
AU - Chen, Nanhao
AU - Guo, Qianbei
AU - Gu, Chenxia
AU - Xu, Didi
AU - Cui, Ran
AU - Wang, Jiayi
AU - Li, Mengdan
AU - Yang, Dongxue
AU - Song, Chen
AU - Yu, Jie
AU - Gao, Zhaobing
AU - Ge, Jingpeng
TI - Cryo-EM structures of heteromeric Kir4.1/5.1 channel suggest mechanisms of inward rectification and channel blockage
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/06/06
VL - 17
IS - 1
SP - 7216
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-74087-9
UR - https://doi.org/10.1038/s41467-026-74087-9
LA - en
ER -

CSL-JSON

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