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Structural and functional studies of inward rectifier Kir7.1 and its regulation by the Melanocortin-4 receptor.

Overview

Authors: Alys Peisley1, Ciria C Hernandez2, Naima S Dahir3, Laura Koepping1, Ashleigh Raczkowski1, Min Su4, Masoud Ghamari-Langroudi5, Xinrui Ji1, Luis E Gimenez6, Roger D Cone1,7,8
ORCID iDs: Alys Peisley, Masoud Ghamari-Langroudi, Luis E Gimenez, Roger D Cone
  1. Life Sciences Institute, University of Michigan, Ann Arbor, MI USA
  2. Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL USA
  3. Department of Internal Medicine, University of Texas Southwestern, Dallas, TX USA
  4. Department of Biochemistry, University of Missouri, Columbia, MO USA
  5. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN USA
  6. Courage Therapeutics, Newton, MA USA
  7. Department of Molecular and Integrative Physiology, School of Medicine, University of Michigan, Ann Arbor, MI USA
  8. Department of Molecular, Cellular and Developmental Biology, College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI USA
Institutions: University of Michigan (United States); Northwestern University (United States); The University of Texas Southwestern Medical Center (United States); University of Missouri (United States); Vanderbilt University (United States); Vanderbilt University Medical Center (United States); Michigan Medicine (United States)
Journal: Nature communications, volume 17, issue 1, article 9131
Dates: received 21 February 2025; accepted 14 July 2026; published online 27 July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-75941-6 · PMID 42649184 · PMCID PMC13518829 · OpenAlex W7171396965
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: histology / microscopy (modality), human (organism), cellular / molecular (subfield)
Methods: Evoked potentials
Keywords: Hypothalamus, Homeostasis, Structural biology, Biophysics
MeSH: Potassium Channels, Inwardly Rectifying*, Receptor, Melanocortin, Type 4*, Animals, Cryoelectron Microscopy, HEK293 Cells, Humans, Neurons (* major topic)
Topic: Regulation of Appetite and Obesity (Endocrine and Autonomic Systems, Neuroscience), according to OpenAlex
Funding: NIDDK NIH HHS (R01 DK110403, T32 DK101357, R01 DK070332); U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) (RO1 DK070332, RO1 DK110403, T32 DK101357); NIH HHS (S10 OD025203); U.S. Department of Health & Human Services | NIH | National Center for Research Resources (NCRR) (S10OD025203)
Citations: not cited yet (Europe PMC); 50 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Code and data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-75941-6.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 4 keywords, 7 MeSH terms, 4 funders, 49 references.

Cite

This paper

Peisley, A., Hernandez, C. C., Dahir, N. S., Koepping, L., Raczkowski, A., Su, M., Ghamari-Langroudi, M., Ji, X., Gimenez, L. E., & Cone, R. D. (2026). Structural and functional studies of inward rectifier Kir7.1 and its regulation by the Melanocortin-4 receptor. Nature communications, 17(1), 9131. https://doi.org/10.1038/s41467-026-75941-6

BibTeX

@article{peisley2026structural,
author = {Peisley, Alys and Hernandez, Ciria C and Dahir, Naima S and Koepping, Laura and Raczkowski, Ashleigh and Su, Min and Ghamari-Langroudi, Masoud and Ji, Xinrui and Gimenez, Luis E and Cone, Roger D},
title = {{Structural and functional studies of inward rectifier Kir7.1 and its regulation by the Melanocortin-4 receptor}},
journal = {Nature communications},
year = {2026},
month = jul,
volume = {17},
number = {1},
pages = {9131},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-75941-6},
url = {https://doi.org/10.1038/s41467-026-75941-6},
pmid = {42649184},
pmcid = {PMC13518829}
}

RIS

TY - JOUR
AU - Peisley, Alys
AU - Hernandez, Ciria C
AU - Dahir, Naima S
AU - Koepping, Laura
AU - Raczkowski, Ashleigh
AU - Su, Min
AU - Ghamari-Langroudi, Masoud
AU - Ji, Xinrui
AU - Gimenez, Luis E
AU - Cone, Roger D
TI - Structural and functional studies of inward rectifier Kir7.1 and its regulation by the Melanocortin-4 receptor
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/07/27
VL - 17
IS - 1
SP - 9131
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-75941-6
UR - https://doi.org/10.1038/s41467-026-75941-6
LA - en
ER -

CSL-JSON

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