OSCR

Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming.

Overview

Authors: Chun-Hui Duan1,2,3, Pei-Pei Liu1,2,3, Xin Sun4, Wen-Hui Ma1,2,3, Jia-Ying Pang1,2,3, Zi-Han Zhang1,2,3, Xiao Li1,2,3, Lin-Fei Jiao1,2,3, Hong-Zhen Du1,3, Zhao-Qian Teng1,2,3, Hou-Zao Chen4, Chang-Mei Liu1,2,3
  1. Human Organ Physiopathology Emulation System, State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences,Beijing, China
  2. University of Chinese Academy of Sciences,Beijing, China
  3. Beijing Institute for Stem Cell and Regenerative Medicine,Beijing, China
  4. Department of Biochemistry and Molecular Biology, State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing, China
Journal: Nature communications, volume 17, issue 1, article 8165
Dates: received 21 June 2025; accepted 17 June 2026; published online 1 July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-75063-z · PMID 42386732 · PMCID PMC13457567 · OpenAlex W7166838547
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), other condition (population), developmental (subfield)
Methods: Statistics
Keywords: Neural stem cells, Epigenetics and behaviour, Encephalopathy
MeSH: Endoplasmic Reticulum Stress*, Enoyl-CoA Hydratase*, Lipid Metabolism*, Neural Stem Cells*, Neurogenesis*, Activating Transcription Factor 4, Animals, Apoptosis, Cell Differentiation, Cell Proliferation, Fatty Acid Synthase, Type I, Histones, Metabolic Reprogramming, Mice, Mice, Knockout, Taurochenodeoxycholic Acid (* major topic)
Topic: Metabolism and Genetic Disorders (Clinical Biochemistry, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Ministry of Science and Technology of the People's Republic of China (2021YFA1101402, 2024YFA1802600); National Natural Science Foundation of China (National Science Foundation of China) (82271428, 82301346); Institute of Zoology, Chinese Academy of Sciences (2023IOZ0101, 2024IOZ0104); Initiative Scientific Research Program, Beijing Institute for Stem Cell and Regenerative Medicine (2025BS107)
Citations: not cited yet (Europe PMC); 74 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-75063-z.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 3 keywords, 16 MeSH terms, 4 funders, 73 references.

Cite

This paper

Duan, C.-H., Liu, P.-P., Sun, X., Ma, W.-H., Pang, J.-Y., Zhang, Z.-H., Li, X., Jiao, L.-F., Du, H.-Z., Teng, Z.-Q., Chen, H.-Z., & Liu, C.-M. (2026). Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming. Nature communications, 17(1), 8165. https://doi.org/10.1038/s41467-026-75063-z

BibTeX

@article{duan2026loss,
author = {Duan, Chun-Hui and Liu, Pei-Pei and Sun, Xin and Ma, Wen-Hui and Pang, Jia-Ying and Zhang, Zi-Han and Li, Xiao and Jiao, Lin-Fei and Du, Hong-Zhen and Teng, Zhao-Qian and Chen, Hou-Zao and Liu, Chang-Mei},
title = {{Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming}},
journal = {Nature communications},
year = {2026},
month = jul,
volume = {17},
number = {1},
pages = {8165},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-75063-z},
url = {https://doi.org/10.1038/s41467-026-75063-z},
pmid = {42386732},
pmcid = {PMC13457567}
}

RIS

TY - JOUR
AU - Duan, Chun-Hui
AU - Liu, Pei-Pei
AU - Sun, Xin
AU - Ma, Wen-Hui
AU - Pang, Jia-Ying
AU - Zhang, Zi-Han
AU - Li, Xiao
AU - Jiao, Lin-Fei
AU - Du, Hong-Zhen
AU - Teng, Zhao-Qian
AU - Chen, Hou-Zao
AU - Liu, Chang-Mei
TI - Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/07/01
VL - 17
IS - 1
SP - 8165
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-75063-z
UR - https://doi.org/10.1038/s41467-026-75063-z
LA - en
ER -

CSL-JSON

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