OSCR

Serotonergic psychedelics induce distinct patterns of metabolic activity and covariance within biologically informed rat brain networks.

Overview

Authors: Frederik Gudmundsen1,2, Julia Czurylo1,2, Daniel R Rijsketic3,4, Camilla Trang Vo1,2, Janika Fortunato1,2,5, Naja S Jessen1,2, Sophie Woodruff1,2, Christina Baun1,2, Matthias M Herth6,7, Vladimir Shalgunov6,7, Boris D Heifets3,8, Patrick M Fisher5,6, Mikael Palner1,2
ORCID iDs: Daniel R Rijsketic, Janika Fortunato, Sophie Woodruff, Christina Baun, Vladimir Shalgunov, Boris D Heifets, Patrick M Fisher, Mikael Palner
  1. Clinical Physiology and Nuclear Medicine, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
  2. Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark
  3. Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA USA
  4. TensorAnalytics, LLC, Salt Lake City, UT USA
  5. Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark
  6. Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark
  7. Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, Copenhagen, Denmark
  8. Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA
Institutions: University of Southern Denmark (Denmark); Odense University Hospital (Denmark); Stanford Medicine (United States); Stanford University (United States); Copenhagen University Hospital (Denmark); University of Copenhagen (Denmark)
Journal: Nature communications, volume 17, issue 1, article 9340
Dates: received 2 January 2025; accepted 14 July 2026; published online 3 August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-75890-0 · PMID 42675044 · PMCID PMC13529806 · OpenAlex W7172323655
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: PET / SPECT (modality), rat (organism)
Methods: Statistics, Connectivity
Keywords: Neural circuits, Molecular neuroscience
MeSH: Brain*, Hallucinogens*, Nerve Net*, Animals, Fluorodeoxyglucose F18, Lysergic Acid Diethylamide, Male, Positron-Emission Tomography, Psilocybin, Rats, Rats, Sprague-Dawley (* major topic)
Topic: Psychedelics and Drug Studies (Clinical Psychology, Psychology), according to OpenAlex
Funding: Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) (K08 MH110610, P50 DA042012, R01 MH130591); Det Frie Forskningsråd (0169-00030B); NIMH NIH HHS (R01 MH130591, K08 MH110610); Lundbeckfonden (Lundbeck Foundation) (R389-2021-1596); Novo Nordisk Fonden (NNF23OC0082702); NIDA NIH HHS (P50 DA042012)
Citations: not cited yet (Europe PMC); 97 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Tracing map

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-75890-0.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 2 keywords, 11 MeSH terms, 6 funders, 96 references.

Cite

This paper

Gudmundsen, F., Czurylo, J., Rijsketic, D. R., Vo, C. T., Fortunato, J., Jessen, N. S., Woodruff, S., Baun, C., Herth, M. M., Shalgunov, V., Heifets, B. D., Fisher, P. M., & Palner, M. (2026). Serotonergic psychedelics induce distinct patterns of metabolic activity and covariance within biologically informed rat brain networks. Nature communications, 17(1), 9340. https://doi.org/10.1038/s41467-026-75890-0

BibTeX

@article{gudmundsen2026serotonergic,
author = {Gudmundsen, Frederik and Czurylo, Julia and Rijsketic, Daniel R and Vo, Camilla Trang and Fortunato, Janika and Jessen, Naja S and Woodruff, Sophie and Baun, Christina and Herth, Matthias M and Shalgunov, Vladimir and Heifets, Boris D and Fisher, Patrick M and Palner, Mikael},
title = {{Serotonergic psychedelics induce distinct patterns of metabolic activity and covariance within biologically informed rat brain networks}},
journal = {Nature communications},
year = {2026},
month = aug,
volume = {17},
number = {1},
pages = {9340},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-75890-0},
url = {https://doi.org/10.1038/s41467-026-75890-0},
pmid = {42675044},
pmcid = {PMC13529806}
}

RIS

TY - JOUR
AU - Gudmundsen, Frederik
AU - Czurylo, Julia
AU - Rijsketic, Daniel R
AU - Vo, Camilla Trang
AU - Fortunato, Janika
AU - Jessen, Naja S
AU - Woodruff, Sophie
AU - Baun, Christina
AU - Herth, Matthias M
AU - Shalgunov, Vladimir
AU - Heifets, Boris D
AU - Fisher, Patrick M
AU - Palner, Mikael
TI - Serotonergic psychedelics induce distinct patterns of metabolic activity and covariance within biologically informed rat brain networks
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/08/03
VL - 17
IS - 1
SP - 9340
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-75890-0
UR - https://doi.org/10.1038/s41467-026-75890-0
LA - en
ER -

CSL-JSON

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