OSCR

Intrinsic and non-cell-autonomous roles for the neurodevelopmental syndrome-linked transcription factor UNC-3/EBF.

Overview

Authors: Jayson J Smith1,2,3, Seth R Taylor4,5, Honorine Destain1,2, Grace Kim6, David H Hall6, John G White7, David M Miller III4,8, Paschalis Kratsios1,2
ORCID iDs: Jayson J Smith, Seth R Taylor, Honorine Destain, Paschalis Kratsios
  1. Department of Neurobiology, University of Chicago, Chicago, IL USA
  2. University of Chicago Neuroscience Institute, Chicago, IL USA
  3. Department of Biology, Program in Neuroscience, Syracuse University, Syracuse, NY USA
  4. Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN USA
  5. Department of Cell Biology and Physiology, Brigham Young University, Provo, UT USA
  6. Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY USA
  7. MRC Laboratory of Molecular Biology, Cambridge, UK
  8. Program in Neuroscience, Vanderbilt University, Nashville, TN USA
Institutions: University of Chicago (United States); Syracuse University (United States); Brigham Young University (United States); Vanderbilt University (United States); Albert Einstein College of Medicine (United States); MRC Laboratory of Molecular Biology (United Kingdom)
Journal: Nature communications, volume 17, issue 1, article 9632
Dates: received 30 January 2026; accepted 27 July 2026; published online 11 August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-76320-x · PMID 42711312 · PMCID PMC13554116 · OpenAlex W7202192305
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: human (organism), C. elegans (organism), other condition (population)
Methods: Spectral & time-frequency, Statistics, Smoothing, state filtering, decompositions, Machine learning, Evoked potentials, Connectivity
Keywords: Differentiation, Genetics of the nervous system
MeSH: Caenorhabditis elegans*, Caenorhabditis elegans Proteins*, Neurodevelopmental Disorders*, Transcription Factors*, Animals, Axons, Cholinergic Neurons, GABAergic Neurons, Gene Expression Regulation, Developmental, Gene Regulatory Networks, Humans, Motor Neurons, Neurodevelopment (* major topic)
Topic: Genetics, Aging, and Longevity in Model Organisms (Aging, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) (R01 NS116365, R01NS100547, K99 NS140549-01, R21 NS108505, R01 NS118078, R01NS113559); NCRR NIH HHS (G20 RR030956, UL1 RR024975); NINDS NIH HHS (K99 NS140549, R01 NS116365, R01 NS100547, R01 NS113559, R21 NS108505, R01 NS118078); NIDDK NIH HHS (P30 DK058404, U24 DK059637); NCI NIH HHS (P30 CA068485); U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) (OD R24 010943); NEI NIH HHS (P30 EY008126); NIH HHS (P40 OD010440)
Citations: not cited yet (Europe PMC); 161 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

KratsiosLab

License: none: the authors keep all their rights
State: the link answers, verified on 27 September 2026
Evidence: the link answers
Software Heritage: not checked
Found in: “Code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)
At the source: github.com/KratsiosLab

Zenodo 21345127

License: CC-BY-4.0
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Size: 1 file
Software Heritage: not checked
Found in: “Code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)
At the source: zenodo.org/records/21345127

kratsioslab/smith_etal_2026

License: none: the authors keep all their rights
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Commit: 1634b238d2408a454d545c598ce3c90278eb1792, 2 June 2026
Size: 1 file, 0 scripts
Software Heritage: not archived
Found in: the Zenodo archive record
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link answers
  • 27 September 2026: the link answers
At the source: github.com/KratsiosLab/Smith_etal_2026/tree/Publication

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41467-026-76320-x.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 3 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41467-026-76320-x.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 2 keywords, 13 MeSH terms, 8 funders, 159 references.

Cite

This paper

Smith, J. J., Taylor, S. R., Destain, H., Kim, G., Hall, D. H., White, J. G., Miller, D. M., & Kratsios, P. (2026). Intrinsic and non-cell-autonomous roles for the neurodevelopmental syndrome-linked transcription factor UNC-3/EBF. Nature communications, 17(1), 9632. https://doi.org/10.1038/s41467-026-76320-x

BibTeX

@article{smith2026intrinsic,
author = {Smith, Jayson J and Taylor, Seth R and Destain, Honorine and Kim, Grace and Hall, David H and White, John G and Miller, David M and Kratsios, Paschalis},
title = {{Intrinsic and non-cell-autonomous roles for the neurodevelopmental syndrome-linked transcription factor UNC-3/EBF}},
journal = {Nature communications},
year = {2026},
month = aug,
volume = {17},
number = {1},
pages = {9632},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-76320-x},
url = {https://doi.org/10.1038/s41467-026-76320-x},
pmid = {42711312},
pmcid = {PMC13554116}
}

RIS

TY - JOUR
AU - Smith, Jayson J
AU - Taylor, Seth R
AU - Destain, Honorine
AU - Kim, Grace
AU - Hall, David H
AU - White, John G
AU - Miller, David M
AU - Kratsios, Paschalis
TI - Intrinsic and non-cell-autonomous roles for the neurodevelopmental syndrome-linked transcription factor UNC-3/EBF
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/08/11
VL - 17
IS - 1
SP - 9632
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-76320-x
UR - https://doi.org/10.1038/s41467-026-76320-x
LA - en
ER -

CSL-JSON

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The tracing map gets a citation of its own once an author has validated it and it has a DOI.

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