OSCR

Inflammatory neuropathy in mouse and primate models of colorectal cancer.

Overview

Authors: Caitlyn M Gaffney1, Angela M Casaril1, Iqbal Mahmud2, Bo Wei2, Yanyan Jiang1, Nathan T Fiore1, Jialu Liu1, Karen M Valadez1, Elizabeth A Kolb1, Fisher R Cherry1, Lei Shi3, Kenneth Dunner Jr4, Philip L Lorenzi2, Steven R Reiken5, Peter M Grace1,6, Rajasekaran Mahalingam1, Theresa A Guise3, Carolyn L Hodo7, Andrew J Shepherd1,6
ORCID iDs: Iqbal Mahmud, Bo Wei, Jialu Liu, Fisher R Cherry, Philip L Lorenzi, Theresa A Guise, Carolyn L Hodo, Andrew J Shepherd
  1. Department of Translational Neuroscience, The University of Texas MD Anderson Cancer Center, Houston, TX USA
  2. Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX USA
  3. Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX USA
  4. Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX USA
  5. Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY USA
  6. Cancer Neuroscience Program, The University of Texas MD Anderson Cancer Center, Houston, TX USA
  7. Michale E. Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center, Bastrop, TX USA
Institutions: The University of Texas MD Anderson Cancer Center (United States); Columbia University (United States)
Journal: Nature communications, volume 17, issue 1, article 9670
Dates: received 25 July 2024; accepted 4 August 2026; published online 12 August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-76683-1 · PMID 42716932 · PMCID PMC13558776 · OpenAlex W4400951089
Open access: gold, a free copy (OpenAlex)
Preprint: doi:10.1101/2024.07.19.604274
Status: data only
Categories: human (organism), mouse (organism), non-human primate (organism), other condition (population), pain (population), cellular / molecular (subfield)
Methods: Spectral & time-frequency, Statistics, Preprocessing, fMRI & imaging, Single-unit activity, calcium imaging
Keywords: Neurodegeneration, Somatic system, Neuroimmunology, Chronic pain
MeSH: Colorectal Neoplasms*, Peripheral Nervous System Diseases*, Animals, Calcium, Cytokines, Disease Models, Animal, Female, Humans, Inflammation, Macaca mulatta, Macrophages, Male, Mice, Mice, Inbred C57BL, Myelin Sheath, Peripheral Nerves, Ryanodine Receptor Calcium Release Channel, Sensory Receptor Cells (* major topic)
Topic: Pain Mechanisms and Treatments (Physiology, Medicine), according to OpenAlex
Funding: U.S. Department of Defense (United States Department of Defense) (HT9425-25-1-0632); U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) (R61NS140684-01); Rita Allen Foundation; NINDS NIH HHS (R61 NS140684); U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R61NS140684-01)
Citations: not cited yet (Europe PMC); 112 references in the paper
Research resources: RRID:CVCL_B7NQ

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

Tracing map

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Data

Datasets cited

Code and data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-76683-1.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 19 authors, 4 keywords, 18 MeSH terms, 5 funders, 111 references, 1 RRID.

Cite

This paper

Gaffney, C. M., Casaril, A. M., Mahmud, I., Wei, B., Jiang, Y., Fiore, N. T., Liu, J., Valadez, K. M., Kolb, E. A., Cherry, F. R., Shi, L., Dunner, K., Lorenzi, P. L., Reiken, S. R., Grace, P. M., Mahalingam, R., Guise, T. A., Hodo, C. L., & Shepherd, A. J. (2026). Inflammatory neuropathy in mouse and primate models of colorectal cancer. Nature communications, 17(1), 9670. https://doi.org/10.1038/s41467-026-76683-1

BibTeX

@article{gaffney2026inflammatory,
author = {Gaffney, Caitlyn M and Casaril, Angela M and Mahmud, Iqbal and Wei, Bo and Jiang, Yanyan and Fiore, Nathan T and Liu, Jialu and Valadez, Karen M and Kolb, Elizabeth A and Cherry, Fisher R and Shi, Lei and Dunner, Kenneth and Lorenzi, Philip L and Reiken, Steven R and Grace, Peter M and Mahalingam, Rajasekaran and Guise, Theresa A and Hodo, Carolyn L and Shepherd, Andrew J},
title = {{Inflammatory neuropathy in mouse and primate models of colorectal cancer}},
journal = {Nature communications},
year = {2026},
month = aug,
volume = {17},
number = {1},
pages = {9670},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-76683-1},
url = {https://doi.org/10.1038/s41467-026-76683-1},
pmid = {42716932},
pmcid = {PMC13558776}
}

RIS

TY - JOUR
AU - Gaffney, Caitlyn M
AU - Casaril, Angela M
AU - Mahmud, Iqbal
AU - Wei, Bo
AU - Jiang, Yanyan
AU - Fiore, Nathan T
AU - Liu, Jialu
AU - Valadez, Karen M
AU - Kolb, Elizabeth A
AU - Cherry, Fisher R
AU - Shi, Lei
AU - Dunner, Kenneth
AU - Lorenzi, Philip L
AU - Reiken, Steven R
AU - Grace, Peter M
AU - Mahalingam, Rajasekaran
AU - Guise, Theresa A
AU - Hodo, Carolyn L
AU - Shepherd, Andrew J
TI - Inflammatory neuropathy in mouse and primate models of colorectal cancer
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/08/12
VL - 17
IS - 1
SP - 9670
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-76683-1
UR - https://doi.org/10.1038/s41467-026-76683-1
LA - en
ER -

CSL-JSON

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