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Acoustic cell patterning reveals geometry- and substrate-dependent vasculogenesis and human embryo model development.

Overview

Authors: Zhaoyi Xu1, Weiping Li2,3, Xufeng Xue1,4, Nicholas G Schott2, Chenjun Shi3, Ruxin Yang1, Shiyu Sun1, Jeyoon Bok1, Jitao Zhang3, Jan P Stegemann2, Jianping Fu1,2,5, Cheri X Deng1,2,3
ORCID iDs: Zhaoyi Xu, Weiping Li, Xufeng Xue, Jitao Zhang, Jianping Fu, Cheri X Deng
  1. Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI USA
  2. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI USA
  3. Department of Biomedical Engineering, Michigan State University, East Lansing, MI USA
  4. Present Address: Division of Developmental Biology, Center for Stem Cell and Organoid Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH USA
  5. Department of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI USA
Institutions: University of Michigan (United States); Michigan State University (United States); Cincinnati Children's Hospital Medical Center (United States); Michigan Medicine (United States)
Journal: Nature communications, volume 17, issue 1, article 9996
Dates: received 20 June 2025; accepted 11 August 2026; published online 21 August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-76976-5 · PMID 42764291 · PMCID PMC13590644 · OpenAlex W7203861181
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), developmental (subfield)
Methods: Statistics, Spectral & time-frequency, fMRI & imaging
Keywords: Pluripotent stem cells, Biomedical engineering, Morphogenesis
MeSH: Angiogenesis*, Embryo, Mammalian*, Embryonic Development*, Neovascularization, Physiologic*, Animals, Cell Differentiation, Endothelial Cells, Fibroblasts, Gene Expression Regulation, Developmental, Humans, Microphysiological Systems, Neural Tube, Pluripotent Stem Cells, Tissue Engineering (* major topic)
Topic: 3D Printing in Biomedical Research (Biomedical Engineering, Engineering), according to OpenAlex
Funding: National Science Foundation (2325361, 2422149, 2517721, 2213845); National Institutes of Health; Division of Civil, Mechanical and Manufacturing Innovation
Citations: not cited yet (Europe PMC); 71 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it points to a dataset: Zenodo 21265507
  • it says that the data are available on request

Read it in the paper: doi.org/10.1038/s41467-026-76976-5.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Funding: added National Science Foundation: 2325361, 2422149, 2517721, 2213845; National Institutes of Health; Division of Civil, Mechanical and Manufacturing Innovation

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 3 keywords, 14 MeSH terms, 68 references.

Cite

This paper

Xu, Z., Li, W., Xue, X., Schott, N. G., Shi, C., Yang, R., Sun, S., Bok, J., Zhang, J., Stegemann, J. P., Fu, J., & Deng, C. X. (2026). Acoustic cell patterning reveals geometry- and substrate-dependent vasculogenesis and human embryo model development. Nature communications, 17(1), 9996. https://doi.org/10.1038/s41467-026-76976-5

BibTeX

@article{xu2026acoustic,
author = {Xu, Zhaoyi and Li, Weiping and Xue, Xufeng and Schott, Nicholas G and Shi, Chenjun and Yang, Ruxin and Sun, Shiyu and Bok, Jeyoon and Zhang, Jitao and Stegemann, Jan P and Fu, Jianping and Deng, Cheri X},
title = {{Acoustic cell patterning reveals geometry- and substrate-dependent vasculogenesis and human embryo model development}},
journal = {Nature communications},
year = {2026},
month = aug,
volume = {17},
number = {1},
pages = {9996},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-76976-5},
url = {https://doi.org/10.1038/s41467-026-76976-5},
pmid = {42764291},
pmcid = {PMC13590644}
}

RIS

TY - JOUR
AU - Xu, Zhaoyi
AU - Li, Weiping
AU - Xue, Xufeng
AU - Schott, Nicholas G
AU - Shi, Chenjun
AU - Yang, Ruxin
AU - Sun, Shiyu
AU - Bok, Jeyoon
AU - Zhang, Jitao
AU - Stegemann, Jan P
AU - Fu, Jianping
AU - Deng, Cheri X
TI - Acoustic cell patterning reveals geometry- and substrate-dependent vasculogenesis and human embryo model development
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/08/21
VL - 17
IS - 1
SP - 9996
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-76976-5
UR - https://doi.org/10.1038/s41467-026-76976-5
LA - en
ER -

CSL-JSON

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