Identifying maximal beta power from directional subthalamic local field potentials in Parkinson's disease.
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- [1] § Methods › Feature extraction ↔ notebooks/1_bssu_clean_FFT_FOOOF.ipynb, lines 64–177 · score 0.60 · monopolar power, power spectra, peak, active, Spectral, band
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The authors' code
Jupyter notebook · 519 lines · 15 KB · MIT · 1 match
- # %% [markdown]
- # # Removal of artifacts from time series and Fourier Transform to PSD
- # %%
- import os
- import sys
- import importlib
- from importlib import reload
- from dataclasses import dataclass, field, fields
- from itertools import compress
- import pandas as pd
- import numpy as np
- import matplotlib.pyplot as plt
- import ipywidgets as widgets
- from ipywidgets import interact, interact_manual
- from IPython.display import display
- import mplcursors
- #import mpld3
- from cycler import cycler
- import scipy
- import scipy.io as sio
- from scipy import signal
- from scipy.signal import spectrogram, hann, butter, filtfilt, freqz
- from scipy import stats
- import seaborn as sns
- import pingouin as pg
- import itertools
- from itertools import combinations
- from statannotations.Annotator import Annotator
- import statsmodels.api as sm
- import statsmodels.formula.api as smf
- from patsy import dmatrices
- import plotly.express as px
- from sklearn.linear_model import LogisticRegression
- from sklearn.model_selection import train_test_split, RepeatedStratifiedKFold, GridSearchCV
- from sklearn.metrics import classification_report
- from sklearn.decomposition import FastICA
- # import openpyxl
- # from openpyxl import Workbook, load_workbook
- # import xlrd
- import pickle
- import json
- import csv
- #mne
- import mne_bids
- import mne
- from mne.time_frequency import tfr_morlet
- from mne.stats import permutation_cluster_test
- from mne.preprocessing import ICA, create_ecg_epochs
- # TODO: add README file:
- # pip install pingouin
- # pip install statannotations
- # pip install fooof
- # pip install mpldatacursor
- # %%
- jennifer_user_path = os.getcwd()
- while jennifer_user_path[-14:] != 'jenniferbehnke':
- jennifer_user_path = os.path.dirname(jennifer_user_path)
- # directory to this Repository
- project_path = os.path.join(jennifer_user_path, 'code', 'Monopolar_power_estimation', 'monopolar_directional_beta')
- sys.path.append(project_path)
- os.chdir(project_path)
- import src.bssu.utils.find_folders as find_folders
- importlib.reload(find_folders)
- # import PyPerceive
- project_path = find_folders.chdir_repository("Py_Perceive")
- from PerceiveImport.classes import (
- main_class, modality_class, metadata_class,
- session_class, condition_class, task_class,
- contact_class, run_class
- )
- import PerceiveImport.methods.load_rawfile as load_rawfile
- import PerceiveImport.methods.find_folders as PyPerceive_find_folders
- import PerceiveImport.methods.metadata_helpers as metaHelpers
- # import meet
- project_path = find_folders.chdir_repository("meet")
- import meet as meet
- # import all functions from BetaSenSightLongterm
- project_path = find_folders.chdir_repository("BetaSenSightLongterm")
- # tfr, processing
- import src.monopolar_bssu.percept_lfp.artifact_cleaning as artifacts
- import src.monopolar_bssu.percept_lfp.FourierTransform_clean_data as FFT_clean
- import src.monopolar_bssu.percept_lfp.bssu_from_source_JSON as bssu_from_source_JSON
- import src.monopolar_bssu.percept_lfp.fooof_fit as fooof_fit
- # monopolar Referencing
- import src.bssu.monopolar.MonoRef_JLB as MonoRefJLB
- import src.bssu.monopolar.GroupMonopolarPSD as groupMonopol
- import src.bssu.monopolar.monoRef_weightPsdAverageByCoordinateDistance as MonoRefWeightedCoordinateDistance
- import src.bssu.monopolar.externalized_lfp as externalized
- import src.bssu.monopolar.monopol_method_comparison as monopol_comparison
- import src.bssu.monopolar.bssu_contacts_maximal_beta as bssu_contacts
- import src.bssu.monopolar.monoRef_Strelow as detec_strelow
- # Ranking Order
- import src.bssu.ranking.HighestRankedChannelPSD as highestRank
- import src.bssu.ranking.monopolPSDaverage_withinSubject as PSDaverageMonopol
- import src.bssu.ranking.BIPchannelGroups_ranks as BIP_ranks
- import src.bssu.ranking.Permutation_rankings as Permute_ranks
- # Clinical stimulation parameters
- import src.bssu.stimulation.activeStimulationContacts as activeStimContacts
- # utility functions
- import src.bssu.utils.loadResults as loadResults
- import src.bssu.utils.find_folders as find_folders
- import src.bssu.utils.writeGroupDataframes as writeGroupDF
- import src.bssu.utils.load_data_files as load_data
- import src.bssu.utils.monopol_comparison_helpers as mono_comp_helpers
- import src.bssu.utils.sub_session_dict as sub_session_dic
- # import Classes
- from src.bssu.classes import (metadataAnalysis_class, mainAnalysis_class, sessionAnalysis_class,
- channelAnalysis_class, featureAnalysis_class, frequencyBand_class)
- # import mni coordinates
- import src.bssu.mni.load_rotated_coordinates as load_mni
- importlib.reload(BSSuPsd)
- importlib.reload(MonoRefJLB)
- importlib.reload(loadResults)
- importlib.reload(highestRank)
- importlib.reload(groupMonopol)
- importlib.reload(PSDaverageMonopol)
- importlib.reload(FFpsd)
- importlib.reload(find_folders)
- importlib.reload(metadataAnalysis_class)
- importlib.reload(mainAnalysis_class)
- importlib.reload(sessionAnalysis_class)
- importlib.reload(channelAnalysis_class)
- importlib.reload(featureAnalysis_class)
- importlib.reload(frequencyBand_class)
- importlib.reload(PeakFrequency_psd)
- importlib.reload(power_spectra_plots)
- importlib.reload(BIP_channelGroups)
- importlib.reload(BIP_ranks)
- importlib.reload(activeStimContacts)
- importlib.reload(Permute_ranks)
- importlib.reload(BIP_perChannel)
- importlib.reload(load_mni)
- importlib.reload(writeGroupDF)
- importlib.reload(MonoRefWeightedCoordinateDistance)
- importlib.reload(load_data)
- importlib.reload(externalized)
- importlib.reload(monopol_comparison)
- importlib.reload(bssu_contacts)
- importlib.reload(mono_comp_helpers)
- importlib.reload(detec_strelow)
- importlib.reload(move_artifacts)
- importlib.reload(artifacts)
- importlib.reload(sub_session_dict)
- importlib.reload(FFT_clean)
- importlib.reload(bssu_from_source_JSON)
- importlib.reload(fooof_fit)
- # %%
- # load if you want to see complete Dataframes
- pd.set_option("display.max_rows", None)
- # %%
- # for interactive plots
- # %matplotlib ipympl
- # for static plots
- %matplotlib inline
- # %% [markdown]
- # ## 1. Run a script to clean ECG artifacts out of BSSU Channels
- # %% [markdown]
- # 1. Choose subjects and sessions that show ECG artifacts
- # 2. Visualize raw time series
- # 3. Fit ICA and visualize its components
- # 4. Pick which component contains the ECG artifact
- # 5. Clean the ECG artifact from the original data
- # 6. Plot the cleaned data and save
- # %%
- load_pyPerceive = artifacts.load_mne_object_pyPerceive(sub="059", session="fu12m", channel_group="SegmInterR")
- # %%
- load_pyPerceive.get_data()
- # %%
- load_json = bssu_from_source_JSON.load_json_data_if_perceive_error(sub="030", session="fu24m", condition="m0s0")
- # %%
- ecg_artifact_excel = artifacts.get_ecg_artifact_excel()
- # %% [markdown]
- # Run the cleaning script for each subject
- # %%
- clean_artifacts_one_sub_all_sessions = artifacts.ecg_cleaning("019")
- # %% [markdown]
- # %% [markdown]
- # Load 2D arrays of channel groups singularly
- # %%
- load_cleaned_pickle_file = FFT_clean.load_clean_data(sub="021", session="fu3m", channel_group="SegmInterR")
- load_cleaned_pickle_file
- # %%
- loadJSON = bssu_from_source_JSON.load_json_data_if_perceive_error(sub="030", session="fu24m", condition="m0s0")
- # %% [markdown]
- # ## 2. Plot the Power Spectra of the clean data
- # %%
- # plot the clean power spectra
- sub_list = ["017", "019", "021", "024", "025", "026", "028", "029", "030", "031", "032", "033", "036",
- "038", "040", "041", "045", "047", "048", "049", "050", "052", "055", "059", "060", "061", "062", "063", "065", "066"]
- filter_list = ["band-pass", "unfiltered"]
- for sub in sub_list:
- for filt in filter_list:
- plot_clean_power_spectra = FFT_clean.plot_power_spectrum(sub=sub, normalization="rawPsd", filter=filt)
- # %% [markdown]
- # ## 3. Write the JSON Files of the clean Power spectra in all normalization forms
- # - Important for running FOOOF afterwards
- # %%
- # write the cleaned data to a pickle file
- sub_list = ["017", "019", "021", "024", "025", "026", "028", "029", "030", "031", "032", "033", "036",
- "038", "040", "041", "045", "047", "048", "049", "050", "052", "055", "059", "060", "061", "062", "063", "065", "066"]
- for sub in sub_list:
- clean_data_file = FFT_clean.write_clean_json_files_with_psd(sub=sub)
- # %% [markdown]
- # Load the clean PSD file for each subject
- # %%
- clean_power_spectra = loadResults.load_sub_pickle_file(sub="017", filename="SPECTROGRAMPSD_clean")
- clean_power_spectra
- # %% [markdown]
- # ## 4. Run FOOOF for all clean power spectra
- # %%
- fooof_single_sub = fooof_fit.fooof_fit_single_cleaned(subject="019", fooof_version="v2")
- # %%
- fooof_all_subjects = fooof_fit.fooof_group_percept_clean(incl_sub= ["017", "019", "021", "024", "025", "026",
- "028", "029", "030", "031", "032", "033",
- "036", "038", "040", "041", "045", "047",
- "048", "049", "050", "052", "055", "059",
- "060", "061", "062", "063", "065", "066"], fooof_version="v2")
- # %% [markdown]
- # Read the group FOOOF file
- # %%
- loaded_fooof_result = loadResults.load_pickle_group_result(filename="fooof_group_data_percept", fooof_version="v2")
- loaded_fooof_result.head()
- # %% [markdown]
- # ## Plot raw time series from each subject hemisphere, session and channel group in M0S0
- # %%
- mne_object = artifacts.load_mne_object_pyPerceive(sub="033", session="fu12m", channel_group="SegmIntraL")
- # %%
- plot_time_series = artifacts.plot_ieeg_data(sub="024", session="fu18m", channel_group="SegmIntraL", ieeg_data=mne_object.get_data(), fig_title="raw_time_series")
- # %%
- plot_time_series = artifacts.plot_raw_time_series_before_MNE(sub="024", session="fu18m", channel_group="SegmIntraL")
- # %% [markdown]
- # Plot a group of raw time series...
- # %%
- time_series = artifacts.plot_raw_time_series(
- incl_sub=["024"],
- incl_session=["fu18m"],
- incl_condition=["m0s0"],
- )
- # %% [markdown]
- # FIT ICA
- # - n_components: if the artifact is strong, not many components needed
- # - include all EEG channels including those without ecg artifacts
- # - FastICA input must be 2D array: rows = time points, columns = channels
- # %%
- data = mne_object.get_data() # 2D shape (n_channels in rows, n_times in columns)
- # %%
- # Step 1: Initialize ICA
- # Function to fit data in shape (n_channels, n_times) to ICA
- # Output: tuple (ica_components, n_components)
- fit_ica = artifacts.fit_ica_on_channel_group(data)
- # %%
- ica_components = fit_ica[0]
- n_components = fit_ica[1]
- # %%
- # Step 2: Plot ICA components and visually inspect to find the component with the ECG artifact
- plot_components = artifacts.plot_ica_components(data)
- # %%
- # Step 3: Remove ECG artifact from data
- # %%
- # Step 3: Identify the component representing ECG artifact (replace 5 with the actual index)
- ecg_component_index = 5
- ecg_component = ica_components[:, ecg_component_index]
- # Step 3: Remove ECG artifact contribution from the initial EEG data
- # try different scaling of the ECG component
- scaled_ecg_component = 0.5 * ecg_component
- cleaned_ieeg_data = data.T - np.outer(scaled_ecg_component, ica.mixing_[:, ecg_component_index]) # both shape times x channels
- # Now, cleaned_ieeg_data contains the EEG data with the ECG artifact removed
- # Note: Depending on the scaling of the components, you might need to adjust the amplitude of the subtracted signal to achieve the desired artifact removal.
- # You may also need to experiment with the sign of the subtracted signal.
- # If the artifact is not completely removed, you can try multiplying the ECG component by a scaling factor before subtraction.
- # %%
- cleaned_ieeg_data.shape
- # %%
- # plot the cleaned channels
- cleaned_ieeg_data_transposed = cleaned_ieeg_data.T
- time_points = np.arange(cleaned_ieeg_data_transposed.shape[1])
- n_channels = cleaned_ieeg_data_transposed.shape[0]
- plt.figure(figsize=(100, 20))
- fig, axes = plt.subplots(n_channels, 1, figsize=(60, 2 * n_channels), sharex=True, sharey=True)
- for i in range(n_channels):
- axes[i].plot(time_points, cleaned_ieeg_data_transposed[i], label=f'Channel {i + 1}')
- axes[i].set_ylabel(f'Amplitude (Component {i + 1})')
- axes[n_channels - 1].set_xlabel('Time points')
- plt.tight_layout()
- plt.show()
- # %% [markdown]
- # Using MNE ICA: first re-create the raw MNE objects in PyPerceive and add the info chs kind: "dbs" or "ieeg"
- # - without a channel type ICA won't work
- # %%
- for chan in mne_object.info["chs"]:
- print(f"Channel Name: {chan['ch_name']}, Channel Type: {chan['kind']}")
- # %%
- mne_object.info["chs"]
- # %%
- #picks = mne.pick_types(mne_object.info, eeg=True, meg=False, stim=False, eog=False, exclude=[])
- all_picks = range(mne_object.info['nchan'])
- ica = ICA(n_components=20, random_state=97, max_iter="auto")
- ica.fit(mne_object, picks=all_picks)
- # %%
- ica.plot_components()
- plt.show()
- ica.exclude = [ecg_component_index] # Replace with the index of the ECG component
- cleaned_data = ica.apply(raw_data)
- plt.plot(cleaned_data[0]) # Replace 0 with the appropriate channel index
- plt.title('Cleaned Data without ECG Artifact')
- plt.show()
- # %%
- load_movement_artifact_table = loadResults.load_preprocessing_files(
- signal_filter="band-pass", table="movement_artifact_coord"
- )
- # %%
- table = load_movement_artifact_table
- table
- # %%
- clean_power_spectra_table = loadResults.load_preprocessing_files(
- table="cleaned_power_spectra"
- )
- clean_power_spectra_table
- # %%
- move_artifacts.plot_clean_power_spectra(signal_filter="band-pass")
- # %%
- hemisphere = "Right"
- # depending on hemisphere: define incl_contact
- incl_contact = {}
- if hemisphere == "Right":
- incl_contact["Right"] = ["RingR", "SegmIntraR", "SegmInterR"]
- elif hemisphere == "Left":
- incl_contact["Left"] = ["RingL", "SegmIntraL", "SegmInterL"]
- mainclass_sub = main_class.PerceiveData(
- sub = "017",
- incl_modalities= ["survey"],
- incl_session = ["fu3m"],
- incl_condition = ["m0s0"],
- incl_task = ["rest"],
- incl_contact=incl_contact[f"{hemisphere}"]
- )
- # %%
- for cont, contact in enumerate(incl_contact[f"{hemisphere}"]):
- time_series = getattr(mainclass_sub.survey, "fu3m")
- #time_series = getattr(mainclass_sub, "m0s0")
- #time_series = getattr(mainclass_sub.rest, contact)
- #time_series = time_series.run1.data
- # %%
- data = time_series.m0s0.rest.RingR.run1.data
- # %%
- channel_1=data.get_data()[0, :]
- # %%
- fig, ax = plt.subplots()
- lines = ax.plot(channel_1)
- ax.set_title("Mouse over a point")
- ax.plot(channel_1)
- x = np.arange(1, len(channel_1)+1)
- y = channel_1
- pos = []
- def onclick(event):
- pos.append([event.xdata,event.ydata])
- fig.canvas.mpl_connect('button_press_event', onclick)
- fig.show()
- # %%
- pos
- # %%
- time_series = move_artifacts.plot_raw_time_series(
- incl_sub=["024", "025"],
- incl_session=["fu3m", "fu12m"],
- incl_condition=["m0s0"],
- filter="band-pass"
- )
- # %%
- time_series["time_series"]
- # %%
- first = [x_list[0] for x_list in time_series["pos"]]
- second = [y_list[1] for y_list in time_series["pos"]]
- df = pd.DataFrame({"x": first, "y": second})
- df
- # %%
- # %% [markdown]
- # ## Plot Time Frequency Plots of all subject hemispheres
- # %%
- plot_time_frequency = TF.time_frequency(
- incl_sub=["017"],
- incl_session=["postop", "fu3m", "fu12m", "fu18m"],
- incl_condition=["m0s0"],
- filter_signal="band-pass"
- )
- # %%
1_bssu_clean_FFT_FOOOF.ipynb at commit 0a9fb48, under MIT · at the source
Overview
- Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité University Medicine,Berlin, Germany
- Berlin Institute of Health (BIH),Berlin, Germany
- Department of Neurology, University Hospital,Würzburg, Germany
- Department of Brain Sciences, Imperial College,London, UK
- UK Dementia Research Institute, Imperial College,London, UK
- Research Group Neural Interactions and Dynamics, Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences,Leipzig, Germany
- Humboldt-Universität zu Berlin, Berlin School of Mind and Brain,Berlin, Germany
- Department of Neurosurgery, Charité University Medicine,Berlin, Germany
- Department of Neurosurgery, University Hospital,Düsseldorf, Germany
- NeuroCure Clinical Research Centre, Charité University Medicine,Berlin, Germany
- German Center for Neurodegenerative Diseases (DZNE),Berlin, Germany
Abstract
Accurate subthalamic beta activity could guide deep brain stimulation programming in Parkinson’s disease, but bipolar recordings complicate contact selection. In 39 patients, we validated three methods to estimate pseudo-monopolar beta power. Distance-weighted methods (Euclidean, Strelow) agreed consistently with the externalized “ground-truth” beta distribution. Maximal beta power across 20s windows was more stable in ring than in directional channels. Beta-contacts from all methods aligned with clinically active stimulation contacts one year after surgery.
Reproduced under the paper's license (CC BY), from the paper cited above.
Repository
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JKBehnke/monopolar_directional_beta
0a9fb4836c4e5fef615901c8639800101eba371e, 22 October 2024Availability: 1 check, the latest on 28 September 2026: the link answers
- 28 September 2026: the link answers
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- notebooks/
1_bssu_clean_FFT_FOOOF.i , Jupyter, 519 lines, 1 matchpynb - repository limit reached (2,000 files or 30 MB): the rest is at the source (35 files)
- LICENSE, License, 21 lines
- README.md, Text, 2 lines
Code availability
The underlying code for this study is available in the repository ‘monopolar_directional_b
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
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Data availability
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 15 authors, 2 keywords, 8 funders, 24 references.
Cite
This paper
Behnke, J. K., Peach, R. L., Gerster, M., Köhler, R. M., Habets, J. G. V., Busch, J. L., Mathiopoulou, V., Kaplan, J., Feldmann, L. K., Vivien, J., Ip, C. W., Schneider, G.-H., Faust, K., Krause, P., & Kühn, A. A. (2026). Identifying maximal beta power from directional subthalamic local field potentials in Parkinson's disease. NPJ Parkinson's disease, 12(1), 114. https://
BibTeX
@article{behnke2026ident
author = {Behnke, Jennifer K. and Peach, Robert L. and Gerster, Moritz and Köhler, Richard M. and Habets, Jeroen G. V. and Busch, Johannes L. and Mathiopoulou, Varvara and Kaplan, Jonathan and Feldmann, Lucia K. and Vivien, Juliette and Ip, Chi Wang and Schneider, Gerd-Helge and Faust, Katharina and Krause, Patricia and Kühn, Andrea A.},
title = {{Identifying maximal beta power from directional subthalamic local field potentials in Parkinson's disease}},
journal = {NPJ Parkinson's disease},
year = {2026},
month = may,
volume = {12},
number = {1},
pages = {114},
publisher = {Nature Publishing Group},
issn = {2373-8057},
doi = {10.1038/
url = {https://
pmid = {42103747},
pmcid = {PMC13156298}
}
RIS
TY - JOUR
AU - Behnke, Jennifer K.
AU - Peach, Robert L.
AU - Gerster, Moritz
AU - Köhler, Richard M.
AU - Habets, Jeroen G. V.
AU - Busch, Johannes L.
AU - Mathiopoulou, Varvara
AU - Kaplan, Jonathan
AU - Feldmann, Lucia K.
AU - Vivien, Juliette
AU - Ip, Chi Wang
AU - Schneider, Gerd-Helge
AU - Faust, Katharina
AU - Krause, Patricia
AU - Kühn, Andrea A.
TI - Identifying maximal beta power from directional subthalamic local field potentials in Parkinson's disease
T2 - NPJ Parkinson's disease
J2 - NPJ Parkinsons Dis
PY - 2026
DA - 2026/
VL - 12
IS - 1
SP - 114
SN - 2373-8057
PB - Nature Publishing Group
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
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}
}
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