OSCR

The SHEDs-derived apoptotic bodies for inflammatory regulation in spinal cord repair.

Overview

Authors: Lihua Luo1, Na Dong2,3, Junpeng Xu2,3, Chen Zhang1, Sa Bao1, Haichao Xu1, Xiping Wang1, Peng Dai3, Caiyan Li3, Qiao Zhang2,3, Yibo Ying2,3, Dawei Jiang2,3, Shengcun Li3,4, Ping Wu2,3, Liqing Mei1, Xiaokun Li2,3, Junjie Deng5,6, Yihuai Pan1, Zhouguang Wang2,3
  1. School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China
  2. The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
  3. Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), National Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China
  4. Rehabilitation Medicine Center, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
  5. Joint Centre of Translational Medicine, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China
  6. Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China
Institutions: Wenzhou Medical University (China); First Affiliated Hospital of Wenzhou Medical University (China); Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (China); Wenzhou Institute, University of Chinese Academy of Sciences (China)
Journal: NPJ Regenerative medicine, volume 11, issue 1, article 30
Dates: received 22 January 2025; accepted 29 March 2026; published online 23 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41536-026-00475-w · PMID 42026088 · PMCID PMC13316036 · OpenAlex W7155419432
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: other condition (population), cellular / molecular (subfield)
Methods: Statistics, Machine learning, Preprocessing, Spectral & time-frequency
Keywords: Adult stem cells, Mesenchymal stem cells, Stem cells, Neuroscience, Regeneration and repair in the nervous system, Spinal cord injury, Diseases, Neurological disorders, Spinal cord diseases
Topic: Phagocytosis and Immune Regulation (Immunology, Immunology and Microbiology), according to OpenAlex
Funding: Zhejiang Provincal Postdoctoral Science Foundation (ZJ2024168); Ningbo Natural Science Foundation (2024J359); Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang (2023R01002); Postdoctoral Fellowship Program of CPSF (GZC20241251)
Citations: not cited yet (Europe PMC); 147 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the code is available on request

Read it in the paper: doi.org/10.1038/s41536-026-00475-w.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.

Data

No dataset and no data link were found in the paper.

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the data are available on request

Read it in the paper: doi.org/10.1038/s41536-026-00475-w.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 19 authors, 9 keywords, 4 funders, 144 references.

Cite

This paper

Luo, L., Dong, N., Xu, J., Zhang, C., Bao, S., Xu, H., Wang, X., Dai, P., Li, C., Zhang, Q., Ying, Y., Jiang, D., Li, S., Wu, P., Mei, L., Li, X., Deng, J., Pan, Y., & Wang, Z. (2026). The SHEDs-derived apoptotic bodies for inflammatory regulation in spinal cord repair. NPJ Regenerative medicine, 11(1), 30. https://doi.org/10.1038/s41536-026-00475-w

BibTeX

@article{luo2026sheds,
author = {Luo, Lihua and Dong, Na and Xu, Junpeng and Zhang, Chen and Bao, Sa and Xu, Haichao and Wang, Xiping and Dai, Peng and Li, Caiyan and Zhang, Qiao and Ying, Yibo and Jiang, Dawei and Li, Shengcun and Wu, Ping and Mei, Liqing and Li, Xiaokun and Deng, Junjie and Pan, Yihuai and Wang, Zhouguang},
title = {{The SHEDs-derived apoptotic bodies for inflammatory regulation in spinal cord repair}},
journal = {NPJ Regenerative medicine},
year = {2026},
month = apr,
volume = {11},
number = {1},
pages = {30},
publisher = {Nature Publishing Group},
issn = {2057-3995},
doi = {10.1038/s41536-026-00475-w},
url = {https://doi.org/10.1038/s41536-026-00475-w},
pmid = {42026088},
pmcid = {PMC13316036}
}

RIS

TY - JOUR
AU - Luo, Lihua
AU - Dong, Na
AU - Xu, Junpeng
AU - Zhang, Chen
AU - Bao, Sa
AU - Xu, Haichao
AU - Wang, Xiping
AU - Dai, Peng
AU - Li, Caiyan
AU - Zhang, Qiao
AU - Ying, Yibo
AU - Jiang, Dawei
AU - Li, Shengcun
AU - Wu, Ping
AU - Mei, Liqing
AU - Li, Xiaokun
AU - Deng, Junjie
AU - Pan, Yihuai
AU - Wang, Zhouguang
TI - The SHEDs-derived apoptotic bodies for inflammatory regulation in spinal cord repair
T2 - NPJ Regenerative medicine
J2 - NPJ Regen Med
PY - 2026
DA - 2026/04/23
VL - 11
IS - 1
SP - 30
SN - 2057-3995
PB - Nature Publishing Group
DO - 10.1038/s41536-026-00475-w
UR - https://doi.org/10.1038/s41536-026-00475-w
LA - en
ER -

CSL-JSON

{
"id": "10.1038/s41536-026-00475-w",
"type": "article-journal",
"title": "The SHEDs-derived apoptotic bodies for inflammatory regulation in spinal cord repair",
"container-title": "NPJ Regenerative medicine",
"author": [
{
"family": "Luo",
"given": "Lihua"
},
{
"family": "Dong",
"given": "Na"
},
{
"family": "Xu",
"given": "Junpeng"
},
{
"family": "Zhang",
"given": "Chen"
},
{
"family": "Bao",
"given": "Sa"
},
{
"family": "Xu",
"given": "Haichao"
},
{
"family": "Wang",
"given": "Xiping"
},
{
"family": "Dai",
"given": "Peng"
},
{
"family": "Li",
"given": "Caiyan"
},
{
"family": "Zhang",
"given": "Qiao"
},
{
"family": "Ying",
"given": "Yibo"
},
{
"family": "Jiang",
"given": "Dawei"
},
{
"family": "Li",
"given": "Shengcun"
},
{
"family": "Wu",
"given": "Ping"
},
{
"family": "Mei",
"given": "Liqing"
},
{
"family": "Li",
"given": "Xiaokun"
},
{
"family": "Deng",
"given": "Junjie"
},
{
"family": "Pan",
"given": "Yihuai"
},
{
"family": "Wang",
"given": "Zhouguang"
}
],
"container-title-short": "NPJ Regen Med",
"volume": "11",
"issue": "1",
"page": "30",
"DOI": "10.1038/s41536-026-00475-w",
"PMID": "42026088",
"PMCID": "PMC13316036",
"ISSN": "2057-3995",
"publisher": "Nature Publishing Group",
"URL": "https://doi.org/10.1038/s41536-026-00475-w",
"language": "en",
"issued": {
"date-parts": [
[
2026,
4,
23
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1371/journal.pcbi.1014573 [code]
Cell-type-specific m1A dynamics are associated with microglial phenotypic transition and neuronal metabolic adaptation during spinal cord injury.
Journal: PLoS computational biology
In common: other condition, cellular / molecular, 3 references
[2] doi:10.1038/s41598-026-48842-3 [code]
PLX5622 did not alter anxiety-like behaviour and showed limited microglial depletion efficacy in a spinal cord injury model in female rats.
Journal: Scientific reports
In common: other condition, cellular / molecular, 3 references
[3] doi:10.1002/ctm2.70683 [code]
Niacin promotes motor function recovery after spinal cord injury via Hcar2-dependent microglia immunometabolic regulation.
Journal: Clinical and translational medicine
In common: other condition, cellular / molecular, 3 references
[4] doi:10.1002/cns.70834
Wnt5a-Induced Exosomes From Bone Marrow Mesenchymal Stem Cells Promote Spinal Cord Injury Repair by Modulating Immune Cell Phenotypes and Alleviating Neuroinflammation via the NF-κB Pathway.
Journal: CNS neuroscience & therapeutics
In common: other condition, cellular / molecular, 2 references
[5] doi:10.1002/jev2.70347
Lymphatic Drainage of Cerebrospinal Fluid Using Lymph Node Seeker 64Cu-Labeled Gram-Negative Bacterial Extracellular Vesicles With Positron Emission Tomography (PET).
Journal: Journal of extracellular vesicles
In common: cellular / molecular, 2 references
[6] doi:10.1016/j.celrep.2026.117418 [code]
Astrocyte-microglia crosstalk via CSF1 and IFN-β promotes central nervous system repair.
Journal: Cell reports
In common: other condition, cellular / molecular, 2 references
[7] doi:10.1016/j.neurot.2026.e00868
Persistent histone H3K27 acetylation contributes to excessive scar formation after spinal cord injury through the regulation of microglial cholesterol accumulation.
Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
In common: other condition, cellular / molecular, 2 references
[8] doi:10.1038/s41467-026-71919-6 [code]
Suppression of astrocyte BMP signaling improves molecular signatures and functional deficits in a fragile X syndrome mouse model.
Journal: Nature communications
In common: other condition, cellular / molecular, 1 reference
[9] doi:10.1007/s10571-026-01749-z
Nyap1 Redirects JNK Signaling to Couple Neuroprotection with Circuit Regeneration After Spinal Cord Injury.
Journal: Cellular and molecular neurobiology
In common: other condition, cellular / molecular, 1 reference
[10] doi:10.1371/journal.ppat.1014115 [code]
Venezuelan equine encephalitis virus infection causes chronic neurobehavioral outcomes, cellular remodeling, and hippocampal single-cell transcriptomic changes.
Journal: PLoS pathogens
In common: other condition, cellular / molecular, 1 reference

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.