Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma.

1. Texas Children’s Cancer and Hematology Center, Texas Children’s Hospital, Houston, TX USA
2. Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, TX USA
3. The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario Canada
4. Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario Canada
5. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario Canada
6. Department of Medical Biophysics, University of Toronto, Toronto, Ontario Canada
7. Department of Human Genetics, McGill University, Montreal, Quebec Canada
8. Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec Canada
9. Development, Disease Models and Therapeutics Graduate Program, Baylor College of Medicine, Houston, TX USA
10. Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA USA
11. Division of Metabolism and Endocrinology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA USA
12. Department of Neurological Surgery, Northwestern University, Chicago, IL USA
13. Section of Neurosurgery, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta Canada
14. Department of Pediatrics, Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL USA
15. Key Laboratory of Birth Defects, Children’s Hospital of Fudan University, Shanghai, China
16. Department of Neurosurgery, St Michael’s Hospital, Toronto, Ontario Canada
17. Department of Systems Biology, Columbia University Medical Center, New York, NY USA
18. Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario Canada
19. Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY USA
20. Vector Institute, Toronto, Ontario Canada
21. Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario Canada
22. Case Comprehensive Cancer Center, Cleveland, OH USA
23. Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH USA
24. Center for Cancer and Immunology, Brain Tumor Institute, Children’s National Hospital, Washington, DC USA
25. Department of Pediatrics, School of Medicine and Health Sciences, George Washington University, Washington, DC USA
26. Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Key Laboratory of Reproductive Medicine, Department of Histoembryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
27. The Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX USA
28. Department of Neurosurgery, Texas Children’s Hospital, Houston, TX USA
29. Department of Neurosurgery, Baylor College of Medicine, Houston, TX USA
30. Department of Computer Science, University of Toronto, Toronto, Ontario Canada
31. Department of Molecular Genetics, University of Toronto, Toronto, Ontario Canada
32. Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario Canada
33. Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
34. National Center for Neurological Disorders, Shanghai, China
35. Department of Pathology, Johns Hopkins University, Baltimore, MD USA
36. Laboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan, Ann Arbor, MI USA
37. Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia Canada
38. Department of Pathology, Mass General Brigham, Harvard Medical School, Boston, MA USA
39. Department of Neurosurgery, Children’s Hospital of Fudan University, Shanghai, China
40. Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
41. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
42. Department of Neurosurgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
43. China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
44. Beijing Neurosurgical Institute, Beijing, China
45. Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
46. Chinese Institute for Medical Research, Beijing, China
47. Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan
48. University of North Carolina at Chapel Hill, Chapel Hill, NC USA
49. Adaptive Oncology, Ontario Institute for Cancer Research, Toronto, Ontario Canada
50. Department of Pediatrics, McGill University, Montreal, Quebec Canada
51. Research Institute of the McGill University Health Center, Montreal, Quebec Canada
52. Division of Haematology and Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario Canada
53. Brain Tumor Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH USA
54. Cancer Biology Program, UPMC Hillman Cancer Center, Pittsburgh, PA USA
55. Department of Surgery, University of Toronto, Toronto, Ontario Canada

@article{zhang2026androgen,
author = {Zhang, Jiao and Ong, Winnie and Rasnitsyn, Alexandra and Gonzalez, Ricardo Daniel and Lopez Gutierrez, Rodrigo and Balin, Polina and Saadeldin, Amr and Wu, Xiaochong and Vladoiu, Maria C and Santa-Maria Lopez, Vicente and Gonzalez-Salinas, Fernando and Yadav, Navneesh and Mohanakrishnan, Dinesh and Boosi Narayana Rao, Kannan and Mooli, Raja Gopal Reddy and Najem, Hinda and Pacheco, Sebastian and Kharas, Kaitlin and Richman, Cory and Przelicki, David and Wang, Evan Y and Su, Haipeng and Curry, Rachel Naomi and Yang, Runze and Kameda-Smith, Michelle Masayo and Livingston, Bryn and Scott, David and Luo, Zaili and Xia, Mingyang and Abeysundara, Namal and Erickson, Anders W and Mankahla, Ncedile and Hu, Lucas ZhongMing and Pan, Chu and Suarez, Raul and Huang, Ning and Wu, Yihao and Wang, Hao and Douglas, Tajana and Pallota, Jonelle and Hébert, Steven and Ng, Karen and Mantione, Krystin and Whetstone, Heather and Maan, Hassaan and Lakkis, Hussein and Lee, Juyeun and Ramakrishnan, Sadeesh K and Pei, Yanxin and Tang, Yujie and Lin, Frank Y and Aldave, Guillermo and Gallo, Marco and Friedlander, Robert M and Notta, Faiyaz and Donovan, Laura K and Chintagumpala, Murali and Wang, Bo and Li, Yun and De Carvalho, Daniel D and Zhang, Zhaolei and Mao, Ying and Hua, Wei and Eberhart, Charles and Lucas, Calixto-Hope G and Venneti, Sriram and Sorensen, Poul H and Delaidelli, Alberto and Li, Hao and Zhou, Wenhao and Kirk, Jason and Tang, Dean G and Jiang, Tao and Liu, Hailong and Lathia, Justin D and Suzuki, Hiromichi and Rich, Jeremy N and Stein, Lincoln D and Jabado, Nada and Ramaswamy, Vijay and Lu, Q Richard and Heimberger, Amy B and Daniels, Craig and Michealraj, Kulandaimanuvel Antony and Kleinman, Claudia L and Taylor, Michael D},
title = {{Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma}},
journal = {Nature},
year = {2026},
month = mar,
volume = {652},
number = {8110},
pages = {763--773},
publisher = {Nature Portfolio},
issn = {0028-0836},
doi = {10.1038/s41586-026-10264-6},
url = {https://doi.org/10.1038/s41586-026-10264-6},
pmid = {41882358},
pmcid = {PMC13083265}
}

TY - JOUR
AU - Zhang, Jiao
AU - Ong, Winnie
AU - Rasnitsyn, Alexandra
AU - Gonzalez, Ricardo Daniel
AU - Lopez Gutierrez, Rodrigo
AU - Balin, Polina
AU - Saadeldin, Amr
AU - Wu, Xiaochong
AU - Vladoiu, Maria C
AU - Santa-Maria Lopez, Vicente
AU - Gonzalez-Salinas, Fernando
AU - Yadav, Navneesh
AU - Mohanakrishnan, Dinesh
AU - Boosi Narayana Rao, Kannan
AU - Mooli, Raja Gopal Reddy
AU - Najem, Hinda
AU - Pacheco, Sebastian
AU - Kharas, Kaitlin
AU - Richman, Cory
AU - Przelicki, David
AU - Wang, Evan Y
AU - Su, Haipeng
AU - Curry, Rachel Naomi
AU - Yang, Runze
AU - Kameda-Smith, Michelle Masayo
AU - Livingston, Bryn
AU - Scott, David
AU - Luo, Zaili
AU - Xia, Mingyang
AU - Abeysundara, Namal
AU - Erickson, Anders W
AU - Mankahla, Ncedile
AU - Hu, Lucas ZhongMing
AU - Pan, Chu
AU - Suarez, Raul
AU - Huang, Ning
AU - Wu, Yihao
AU - Wang, Hao
AU - Douglas, Tajana
AU - Pallota, Jonelle
AU - Hébert, Steven
AU - Ng, Karen
AU - Mantione, Krystin
AU - Whetstone, Heather
AU - Maan, Hassaan
AU - Lakkis, Hussein
AU - Lee, Juyeun
AU - Ramakrishnan, Sadeesh K
AU - Pei, Yanxin
AU - Tang, Yujie
AU - Lin, Frank Y
AU - Aldave, Guillermo
AU - Gallo, Marco
AU - Friedlander, Robert M
AU - Notta, Faiyaz
AU - Donovan, Laura K
AU - Chintagumpala, Murali
AU - Wang, Bo
AU - Li, Yun
AU - De Carvalho, Daniel D
AU - Zhang, Zhaolei
AU - Mao, Ying
AU - Hua, Wei
AU - Eberhart, Charles
AU - Lucas, Calixto-Hope G
AU - Venneti, Sriram
AU - Sorensen, Poul H
AU - Delaidelli, Alberto
AU - Li, Hao
AU - Zhou, Wenhao
AU - Kirk, Jason
AU - Tang, Dean G
AU - Jiang, Tao
AU - Liu, Hailong
AU - Lathia, Justin D
AU - Suzuki, Hiromichi
AU - Rich, Jeremy N
AU - Stein, Lincoln D
AU - Jabado, Nada
AU - Ramaswamy, Vijay
AU - Lu, Q Richard
AU - Heimberger, Amy B
AU - Daniels, Craig
AU - Michealraj, Kulandaimanuvel Antony
AU - Kleinman, Claudia L
AU - Taylor, Michael D
TI - Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma
T2 - Nature
J2 - Nature
PY - 2026
DA - 2026/03/25
VL - 652
IS - 8110
SP - 763
EP - 773
SN - 0028-0836
PB - Nature Portfolio
DO - 10.1038/s41586-026-10264-6
UR - https://doi.org/10.1038/s41586-026-10264-6
LA - en
ER -

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