Androgen loss accelerates brain tumour growth via HPA axis activation.

1. Department of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH USA
2. Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL USA
3. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL USA
4. Rose Ella Burkhardt Brain Tumor Center, Cleveland Clinic, Cleveland, OH USA
5. Case Comprehensive Cancer Center, Cleveland, OH USA
6. Department of Pathology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH USA
7. TGen, Translational Genomics Research Institute, Phoenix, AZ USA
8. The Bartholin Institute, Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
9. Department of Clinical Medicine and Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark
10. Department of Neurosciences, Cleveland Clinic Research, Cleveland, OH USA
11. MOSAIC (Mathematical Oncology Systems Analysis of Imaging Center), Cedars-Sinai, Los Angeles, CA USA
12. Department of Neurosurgery, Computational Biomedicine, and Pathology & Laboratory Medicine, Cedars-Sinai, Los Angeles, CA USA
13. Department of Neurosurgery, Duke University School of Medicine, Durham, NC USA
14. Medical Scientist Training Program, Department of Medicine, Case Western Reserve University, Cleveland, OH USA
15. Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH USA
16. Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, OH USA
17. Department of Pediatrics, St Louis Children’s Hospital, Washington University School of Medicine, St Louis, MO USA
18. Department of Neuroscience, Washington University School of Medicine, St Louis, MO USA
19. Duke Cancer Institute, Duke University School of Medicine, Durham, NC USA
20. Preston Robert Tisch Brain Tumor Center, Duke University School of Medicine, Durham, NC USA

@article{lee2026androgen,
author = {Lee, Juyeun and Chung, Yoon-Mi and Silver, Daniel J and Hao, Yue and Harwood, Dylan Scott Lykke and Ealy, Alyssa and Serapiglia, Amanda M and Curtin, Lee and Benedetti, Julia R and Ballard, Christine Ann Pittman and Lapsley, Kamya and Alvarez-Vazquez, Andrea and Goldberg, Jessica and Li, Cathy and Kaur, Sehaj and Neal, Rian and Wang, Sabrina Z and Kay, Kristen E and Volovetz, Josephine and Hong, Ellen S and Fodor, R’ay and Jarmula, Jakub and Nicosia, Michael and Rubin, Joshua B and Swanson, Kristin R and Ostrom, Quinn T and Panicker, Nikhil and Kristensen, Bjarne Winther and Berens, Michael and Sharifi, Nima and Lathia, Justin D},
title = {{Androgen loss accelerates brain tumour growth via HPA axis activation}},
journal = {Nature},
year = {2026},
month = may,
volume = {653},
number = {8116},
pages = {1184--1195},
publisher = {Nature Portfolio},
issn = {0028-0836},
doi = {10.1038/s41586-026-10451-5},
url = {https://doi.org/10.1038/s41586-026-10451-5},
pmid = {42092136},
pmcid = {PMC13216072}
}

TY - JOUR
AU - Lee, Juyeun
AU - Chung, Yoon-Mi
AU - Silver, Daniel J
AU - Hao, Yue
AU - Harwood, Dylan Scott Lykke
AU - Ealy, Alyssa
AU - Serapiglia, Amanda M
AU - Curtin, Lee
AU - Benedetti, Julia R
AU - Ballard, Christine Ann Pittman
AU - Lapsley, Kamya
AU - Alvarez-Vazquez, Andrea
AU - Goldberg, Jessica
AU - Li, Cathy
AU - Kaur, Sehaj
AU - Neal, Rian
AU - Wang, Sabrina Z
AU - Kay, Kristen E
AU - Volovetz, Josephine
AU - Hong, Ellen S
AU - Fodor, R’ay
AU - Jarmula, Jakub
AU - Nicosia, Michael
AU - Rubin, Joshua B
AU - Swanson, Kristin R
AU - Ostrom, Quinn T
AU - Panicker, Nikhil
AU - Kristensen, Bjarne Winther
AU - Berens, Michael
AU - Sharifi, Nima
AU - Lathia, Justin D
TI - Androgen loss accelerates brain tumour growth via HPA axis activation
T2 - Nature
J2 - Nature
PY - 2026
DA - 2026/05/06
VL - 653
IS - 8116
SP - 1184
EP - 1195
SN - 0028-0836
PB - Nature Portfolio
DO - 10.1038/s41586-026-10451-5
UR - https://doi.org/10.1038/s41586-026-10451-5
LA - en
ER -

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