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Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.

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fuma.ctglab.nl/tutorial

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sites.google.com/a/broadinstitute.org

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bulik/ldsc

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genomicsem/genomicsem

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Zenodo 17478061

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noraistrom/anxgwas2025

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Overview

Authors: Nora I. Strom, Brad Verhulst, Silviu-Alin Bacanu, Rosa Cheesman, Kirstin L. Purves, Hüseyin Gedik, Brittany L. Mitchell, Alex S. Kwong, Annika B. Faucon, Kritika Singh, Sarah Medland, Lucia Colodro-Conde, Kristi Krebs, Per Hoffmann, Stefan Herms, Jan Gehlen, Stephan Ripke, Swapnil Awasthi, Teemu Palviainen, Elisa M. Tasanko
and 117 other authorsRoseann E. Peterson, Daniel E. Adkins, Andrey A. Shabalin, Mark J. Adams, Matthew H. Iveson, Archie Campbell, Laurent F. Thomas, Bendik S. Winsvold, Ole Kristian Drange, Sigrid Børte, Abigail R. ter Kuile, Joonas Naamanka, Tan-Hoang Nguyen, Sandra M. Meier, Elizabeth C. Corfield, Laurie Hannigan, Daniel F. Levey, Darina Czamara, Heike Weber, Karmel W. Choi, Giorgio Pistis, Baptiste Couvy-Duchesne, Sandra Van der Auwera, Alexander Teumer, Robert Karlsson, Miguel Garcia-Argibay, Donghyung Lee, Rujia Wang, Ottar Bjerkeset, Eystein Stordal, Julia Bäckman, Giovanni A. Salum, Clement C. Zai, James L. Kennedy, Gwyneth Zai, Arun K. Tiwari, Stefanie Heilmann-Heimbach, Börge Schmidt, Jaakko Kaprio, Martin M. Kennedy, Joseph Boden, Alexandra Havdahl, Christel M. Middeldorp, Fabiana L. Lopes, Nirmala Akula, Francis J. McMahon, Elisabeth B. Binder, Lydia Fehm, Andreas Ströhle, Enrique Castelao, Henning Tiemeier, Dan J. Stein, David Whiteman, Catherine Olsen, Zachary Fuller, Xin Wang, Naomi R. Wray, Enda M. Byrne, Glyn Lewis, Nicholas J. Timpson, Lea K. Davis, Ian B. Hickie, Nathan A. Gillespie, Lili Milani, Johannes Schumacher, David P. Woldbye, Andreas J. Forstner, Markus M. Nöthen, Iiris Hovatta, John Horwood, William E. Copeland, Hermine H. Maes, Andrew M. McIntosh, Ole A. Andreassen, John-Anker Zwart, Ole Mors, Anders D. Børglum, Preben B. Mortensen, Helga Ask, Ted Reichborn-Kjennerud, Jackob M. Najman, Murray B. Stein, Joel Gelernter, Yuri Milaneschi, Brenda W. Penninx, Dorret I. Boomsma, Eduard Maron, Angelika Erhardt-Lehmann, Christian Rück, Tilo T. Kircher, Christiane A. Melzig, Georg W. Alpers, Volker Arolt, Katharina Domschke, Jordan W. Smoller, Martin Preisig, Nicholas G. Martin, Michelle K. Lupton, Annemarie I. Luik, Andreas Reif, Hans J. Grabe, Henrik Larsson, Patrik K. Magnusson, Albertine J. Oldehinkel, Catharina A. Hartman, Gerome Breen, Anna R. Docherty, Hilary Coon, Rupert Conrad, Kelli Lehto, Veterans Affairs Million Veteran Program, FinnGen, 23andMe Research Team, Jürgen Deckert, Thalia C. Eley, Manuel Mattheisen, John M. Hettema
Published: 3 February 2026
Type: Research article
Status: code verified (how the code is found and verified)
License: CC BY
Institutions: Humboldt-Universität zu Berlin (Germany), Institut für Psychiatrische Phänomik und Genomik (Germany), Stockholm Health Care Services (Sweden), Aarhus University (Denmark), Texas A&M University (United States), Virginia Commonwealth University (United States), University of Oslo (Norway), King's College London (United Kingdom), SUNY Downstate Health Sciences University (United States), QIMR Berghofer Medical Research Institute (Australia), The University of Queensland (Australia), University of Bristol (United Kingdom), University of Edinburgh (United Kingdom), Vanderbilt University (United States), Vanderbilt University Medical Center (United States), University of Tartu (Estonia), University Hospital Bonn (Germany), University of Basel (Switzerland), University Hospital of Basel (Switzerland), Universität Hamburg (Germany), Charité – Universitätsmedizin Berlin (Germany), Massachusetts General Hospital (United States), University of Helsinki (Finland), University of Utah (United States), Norwegian University of Science and Technology (Norway), St Olav's University Hospital (Norway), Oslo University Hospital (Norway), Sørlandet Sykehus (Norway), South London and Maudsley NHS Foundation Trust (United Kingdom), University College London (United Kingdom), Central Institute of Mental Health (Germany), Dalhousie University (Canada), Norwegian Institute of Public Health (Norway), Lovisenberg Diakonale Sykehus (Norway), Yale University (United States), VA Connecticut Healthcare System (United States), Max Planck Institute of Psychiatry (Germany), Universitätsklinikum Würzburg (Germany), University of Lausanne (Switzerland), Institut du Cerveau (France), Universitätsmedizin Greifswald (Germany), Karolinska Institutet (Sweden), Örebro University (Sweden), Miami University (United States), Nord University (Norway), Namsos Hospital (Norway), Universidade Federal do Rio Grande do Sul (Brazil), Instituto Nacional de Psiquiatria do Desenvolvimento para Crianças e Adolescentes (Brazil), Centre for Addiction and Mental Health (Canada), University of Toronto (Canada), Broad Institute (United States), University of Duisburg-Essen (Germany), University of Otago (New Zealand), Child and Youth Mental Health Service, Children’s Health Queensland Hospital and Health Service,Brisbane, Queensland Australia, National Institutes of Health (United States), Brown University (United States), Johns Hopkins University (United States), Harvard University (United States), Erasmus MC (Netherlands), University of Cape Town (South Africa), 23andMe (United States) (United States), University of Oxford (United Kingdom), The University of Sydney (Australia), University of Copenhagen (Denmark), Forschungszentrum Jülich (Germany), University of Vermont (United States), Aarhus University Hospital (Denmark), University of California San Diego (United States), Amsterdam University Medical Centers (Netherlands), Vrije Universiteit Amsterdam (Netherlands), Tallinn University of Technology (Estonia), Imperial College London (United Kingdom), Universität Greifswald (Germany), University of Mannheim (Germany), University of Münster (Germany), University of Freiburg (Germany), Deutsches Zentrum für Psychische Gesundheit (Germany), Queensland University of Technology (Australia), University Hospital Frankfurt (Germany), University Medical Center Groningen (Netherlands), University Hospital Münster (Germany)

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