Norepinephrine and dopamine sensor crosstalk depends on local innervation density.
Overview
- Department of Neurobiology, Harvard Medical School, Boston, MA USA
- Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland
- Neuroscience Center Zürich, ETH and University of Zürich, Zürich, Switzerland
- State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China
Abstract
G-protein-coupled receptor-based fluorescent sensors are widely used to correlate neuromodulatory signaling with brain function. Although experiments in transfected cells often reveal selectivity for individual neurotransmitters, sensor specificity in the brain frequently remains uncertain. Using imaging in mouse brains, we find that norepinephrine and dopamine cross-activate the respective sensors. Non-specific activation occurred when innervation of the cross-reacting transmitter was high, and silencing of specific innervation was indispensable for interpreting sensor fluorescence.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- zenodo:20255734, at Zenodo; found in “Data availability”
Data availability
Data points generated for this study are included in the figures whenever possible. Numerical data presented in figures are available on Zenodo (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 3, 28 September 2026
- Publisher: n/a → Nature Portfolio
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 4 keywords, 9 MeSH terms, 10 funders, 46 references, 11 RRIDs.
Cite
This paper
López, R. C., Noble, N., Özçete, Ö. D., Silenzi, L., Cai, X., Handy, G. E., Andersen, J. W., Patriarchi, T., Li, Y., & Kaeser, P. S. (2026). Norepinephrine and dopamine sensor crosstalk depends on local innervation density. Nature neuroscience, 29(9), 2103-2109. https://
BibTeX
@article{lopez2026norepi
author = {López, Ricardo C and Noble, Natalie and Özçete, Özge D and Silenzi, Leonardo and Cai, Xintong and Handy, Gillian E and Andersen, Jonathan W and Patriarchi, Tommaso and Li, Yulong and Kaeser, Pascal S},
title = {{Norepinephrine and dopamine sensor crosstalk depends on local innervation density}},
journal = {Nature neuroscience},
year = {2026},
month = aug,
volume = {29},
number = {9},
pages = {2103--2109},
publisher = {Nature Portfolio},
issn = {1097-6256},
doi = {10.1038/
url = {https://
pmid = {42557443},
pmcid = {PMC13533832}
}
RIS
TY - JOUR
AU - López, Ricardo C
AU - Noble, Natalie
AU - Özçete, Özge D
AU - Silenzi, Leonardo
AU - Cai, Xintong
AU - Handy, Gillian E
AU - Andersen, Jonathan W
AU - Patriarchi, Tommaso
AU - Li, Yulong
AU - Kaeser, Pascal S
TI - Norepinephrine and dopamine sensor crosstalk depends on local innervation density
T2 - Nature neuroscience
J2 - Nat Neurosci
PY - 2026
DA - 2026/
VL - 29
IS - 9
SP - 2103
EP - 2109
SN - 1097-6256
PB - Nature Portfolio
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
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