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Identification of NFE2L2 as a key biomarker associated with pyroptosis in gliomas through bioinformatics and experiments.

Overview

Authors: Qiusi Tian1, Shiqun Chen2, Qun Zhang2, Juan Chen2,3, Yiguo Zhang2
  1. Department of Neurosurgery, 3201 Hospital of Xi’an Jiaotong University Health Science Center,Hanzhong, 723001 China
  2. The Laboratory of Cell Biochemistry and Topogenetic Regulation, College of Bioengineering, Faculty of Medical Sciences, Chongqing University,No. 174 Shazheng Street, Shapingba District, Chongqing, 400044 China
  3. Bishan Hosipital of Chongqing Medical university,9 Shuangxing Avenue, Biquan Street, Bishan District, Chongqing, 723001 China
Institutions: Xi'an Jiaotong University (China); Chongqing University (China); Chongqing Medical University (China)
Journal: Scientific reports, volume 16, issue 1, article 18914
Dates: received 8 July 2025; accepted 2 March 2026; published online 24 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41598-026-43219-y · PMID 42031779 · PMCID PMC13276307 · OpenAlex W7155516312
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: genetics / omics (modality), human (organism), other condition (population)
Methods: Statistics, Connectivity
Keywords: NFE2L2, Glioma, TCGA-GBMLGG, Pyroptosis, Prognosis, Survival, Biomarkers, Cancer, Computational biology and bioinformatics, Oncology
MeSH: Biomarkers, Tumor*, Brain Neoplasms*, Computational Biology*, Glioma*, NF-E2-Related Factor 2*, Pyroptosis*, Animals, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Prognosis, Retrospective Studies (* major topic)
Topic: Inflammasome and immune disorders (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (National Science Foundation of China) (8247102912)
Citations: not cited yet (Europe PMC); 48 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Code availability statement

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  • it says that the code is available on request

Read it in the paper: doi.org/10.1038/s41598-026-43219-y.

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1038/s41598-026-43219-y.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 5 authors, 10 keywords, 13 MeSH terms, 1 funder, 48 references.

Cite

This paper

Tian, Q., Chen, S., Zhang, Q., Chen, J., & Zhang, Y. (2026). Identification of NFE2L2 as a key biomarker associated with pyroptosis in gliomas through bioinformatics and experiments. Scientific reports, 16(1), 18914. https://doi.org/10.1038/s41598-026-43219-y

BibTeX

@article{tian2026identification,
author = {Tian, Qiusi and Chen, Shiqun and Zhang, Qun and Chen, Juan and Zhang, Yiguo},
title = {{Identification of NFE2L2 as a key biomarker associated with pyroptosis in gliomas through bioinformatics and experiments}},
journal = {Scientific reports},
year = {2026},
month = apr,
volume = {16},
number = {1},
pages = {18914},
publisher = {Nature Publishing Group},
issn = {2045-2322},
doi = {10.1038/s41598-026-43219-y},
url = {https://doi.org/10.1038/s41598-026-43219-y},
pmid = {42031779},
pmcid = {PMC13276307}
}

RIS

TY - JOUR
AU - Tian, Qiusi
AU - Chen, Shiqun
AU - Zhang, Qun
AU - Chen, Juan
AU - Zhang, Yiguo
TI - Identification of NFE2L2 as a key biomarker associated with pyroptosis in gliomas through bioinformatics and experiments
T2 - Scientific reports
J2 - Sci Rep
PY - 2026
DA - 2026/04/24
VL - 16
IS - 1
SP - 18914
SN - 2045-2322
PB - Nature Publishing Group
DO - 10.1038/s41598-026-43219-y
UR - https://doi.org/10.1038/s41598-026-43219-y
LA - en
ER -

CSL-JSON

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"language": "en",
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