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Interaction between systemic arterial reservoir behavior and cerebrovascular vasoreactivity during acute controlled hypocapnia.

Overview

Authors: Yaren Alan1, Ahmet Tas2,3, Muhammed Ikbal Bayhan1,4, Alp Ozcan5, Irem Sezer6, Türker Kundak7, Sabahattin Umman1,8, Tim P van de Hoef9, Jan J Piek2, Kim H Parker10, Murat Sezer1,7,11
ORCID iDs: Yaren Alan, Murat Sezer
  1. Faculty of Medicine, Istanbul University, Istanbul, Turkey
  2. Department of Cardiology, Amsterdam UMC, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands
  3. Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey
  4. Department of Nuclear Medicine, Istanbul University, Istanbul, Turkey
  5. Department of Cardiology, Koc University School of Medicine, Istanbul, Turkey
  6. National Amyloidosis Center, Royal Free Hospital, London, UK
  7. Department of Internal Medicine, Acibadem International Hospital, Istanbul, Turkey
  8. Department of Cardiology, Istanbul University, Istanbul, Turkey
  9. Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
  10. Department of Bioengineering, Imperial College, London, UK
  11. Department of Cardiology, Acibadem International Hospital, Istanbul, Turkey
Institutions: Istanbul University (Türkiye); Amsterdam University Medical Centers (Netherlands); Amsterdam Cardiovascular Sciences (Netherlands); Mehmet Akif Ersoy Göğüs Kalp ve Damar Cerrahisi Eğitim ve Araştırma Hastanesi (Türkiye); Koç University (Türkiye); The Royal Free Hospital (United Kingdom); Acıbadem University (Türkiye); University Medical Center Utrecht (Netherlands); Imperial College London (United Kingdom)
Journal: Scientific reports, volume 16, issue 1, article 23125
Dates: received 5 June 2025; accepted 6 April 2026; published online 19 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41598-026-47967-9 · PMID 42156420 · PMCID PMC13396727 · OpenAlex W7161624539
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: other (modality), human (organism), stroke (population)
Methods: Spectral & time-frequency, Statistics, Connectivity, fMRI & imaging
Keywords: Cerebral carbon dioxide reactivity, Cerebrovascular resistance index, Neurovascular coupling, Neurometabolic coupling, Arterial reservoir–excess pressure analysis, Physiology, Cardiology, Health care, Medical research, Neurology
MeSH: Cerebrovascular Circulation*, Hypocapnia*, Adult, Arterial Pressure, Blood Flow Velocity, Blood Pressure, Carbon Dioxide, Female, Hemodynamics, Humans, Male, Middle Cerebral Artery, Ultrasonography, Doppler, Transcranial, Vascular Resistance, Young Adult (* major topic)
Topic: Traumatic Brain Injury and Neurovascular Disturbances (Neurology, Medicine), according to OpenAlex
Citations: cited by 1 paper (Europe PMC); 54 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41598-026-47967-9.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 10 keywords, 15 MeSH terms, 52 references.

Cite

This paper

Alan, Y., Tas, A., Bayhan, M. I., Ozcan, A., Sezer, I., Kundak, T., Umman, S., van de Hoef, T. P., Piek, J. J., Parker, K. H., & Sezer, M. (2026). Interaction between systemic arterial reservoir behavior and cerebrovascular vasoreactivity during acute controlled hypocapnia. Scientific reports, 16(1), 23125. https://doi.org/10.1038/s41598-026-47967-9

BibTeX

@article{alan2026interaction,
author = {Alan, Yaren and Tas, Ahmet and Bayhan, Muhammed Ikbal and Ozcan, Alp and Sezer, Irem and Kundak, Türker and Umman, Sabahattin and van de Hoef, Tim P and Piek, Jan J and Parker, Kim H and Sezer, Murat},
title = {{Interaction between systemic arterial reservoir behavior and cerebrovascular vasoreactivity during acute controlled hypocapnia}},
journal = {Scientific reports},
year = {2026},
month = may,
volume = {16},
number = {1},
pages = {23125},
publisher = {Nature Publishing Group},
issn = {2045-2322},
doi = {10.1038/s41598-026-47967-9},
url = {https://doi.org/10.1038/s41598-026-47967-9},
pmid = {42156420},
pmcid = {PMC13396727}
}

RIS

TY - JOUR
AU - Alan, Yaren
AU - Tas, Ahmet
AU - Bayhan, Muhammed Ikbal
AU - Ozcan, Alp
AU - Sezer, Irem
AU - Kundak, Türker
AU - Umman, Sabahattin
AU - van de Hoef, Tim P
AU - Piek, Jan J
AU - Parker, Kim H
AU - Sezer, Murat
TI - Interaction between systemic arterial reservoir behavior and cerebrovascular vasoreactivity during acute controlled hypocapnia
T2 - Scientific reports
J2 - Sci Rep
PY - 2026
DA - 2026/05/19
VL - 16
IS - 1
SP - 23125
SN - 2045-2322
PB - Nature Publishing Group
DO - 10.1038/s41598-026-47967-9
UR - https://doi.org/10.1038/s41598-026-47967-9
LA - en
ER -

CSL-JSON

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