Time-resolved laser speckle contrast imaging (TR-LSCI) of cerebral blood flow response to intracranial pressure elevation.
Overview
- University of Kentucky, Department of Biomedical Engineering, Lexington, Kentucky, United States
- Bioptics Technology LLC, Advanced Science & Technology Commercialization Center (ASTeCC), Lexington, Kentucky, United States
- École polytechnique fédérale de Lausanne (EPFL), School of Engineering, Neuchâtel, Switzerland
- University of Alabama at Birmingham, Department of Biomedical Informatics and Data Science, Birmingham, Alabama, United States
- University of Kentucky, Markey Cancer Center, Biostatistics and Bioinformatics Shared Resource Facility, Lexington, Kentucky, United States
- University of Kentucky, Department of Neurosurgery, Lexington, Kentucky, United States
Abstract
Significance: Cerebral autoregulation (CA) reflects the dynamic coupling among cerebral blood flow (CBF), intracranial pressure (ICP), and arterial blood pressure (ABP); its failure contributes to secondary brain injury. Existing bedside methods rely on indirect or spatially limited CBF surrogates and cannot resolve microvascular flow dynamics across space, depth, and time.
Aim: To develop, optimize, and apply a scalable, noncontact time-resolved laser speckle contrast imaging (TR-LSCI) platform for depth-sensitive, high-speed, wide-field CBF imaging during controlled ICP perturbations.
Approach: TR-LSCI synchronized a 20-MHz pulsed laser with a time-gated, single-photon avalanche diode (SPAD) camera (512×512 pixels) to detect diffuse photons at varying path lengths, enabling depth-resolved microvascular CBF imaging. Noise-corrected diffuse speckle analysis was implemented to reduce bias at gates with low signal-to-noise ratio and depth sensitivity was assessed across multiple time gates. Benchtop and mobile TR-LSCI systems were applied in adult rats and a neonatal piglet with synchronized invasive ICP and ABP measurements.
Results: TR-LSCI captured spatially heterogeneous, pulsatile CBF dynamics at up to 52 Hz over large cortical fields of view, with heart rate estimates statistically equivalent to those from ICP and ABP. Consistent CBF trends across gates support robust physiological interpretation despite depth-dependent differences in absolute magnitude. Multivariable analysis identified reproducible, phase-dependent CA transitions encompassing preserved autoregulation, ABP-driven compensation, and ICP-constrained CBF suppression; notably, CBF alone exhibited distinct phase signatures.
Conclusion: TR-LSCI enables dynamic, physiology-informed neurovascular monitoring and supports future bedside CA assessment.
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
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Data underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 2, 28 September 2026
- Authors: added Mehrana Mohtasebi (0000-0002-4689-990X); Paul Mos (0009-0003-5909-5147); Edoardo Charbon (0000-0002-0620-3365); removed Mehrana Mohtasebi; Paul Mos; Edoardo Charbon
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 6 keywords, 12 MeSH terms, 5 funders, 74 references.
Cite
This paper
Fathi, F., Zhang, P., Mohtasebi, M., Mos, P., Bruschini, C., Charbon, E., Chen, J., Chen, L., Yu, G., & Chen, L. (2026). Time-resolved laser speckle contrast imaging (TR-LSCI) of cerebral blood flow response to intracranial pressure elevation. Journal of biomedical optics, 31(8), 086007. https://
BibTeX
@article{fathi2026time,
author = {Fathi, Faraneh and Zhang, Peiwen and Mohtasebi, Mehrana and Mos, Paul and Bruschini, Claudio and Charbon, Edoardo and Chen, Jin and Chen, Li and Yu, Guoqiang and Chen, Lei},
title = {{Time-resolved laser speckle contrast imaging (TR-LSCI) of cerebral blood flow response to intracranial pressure elevation}},
journal = {Journal of biomedical optics},
year = {2026},
month = aug,
volume = {31},
number = {8},
pages = {086007},
publisher = {Society of Photo-Optical Instrumentation Engineers},
issn = {1083-3668},
doi = {10.1117/
url = {https://
pmid = {42666724},
pmcid = {PMC13524067}
}
RIS
TY - JOUR
AU - Fathi, Faraneh
AU - Zhang, Peiwen
AU - Mohtasebi, Mehrana
AU - Mos, Paul
AU - Bruschini, Claudio
AU - Charbon, Edoardo
AU - Chen, Jin
AU - Chen, Li
AU - Yu, Guoqiang
AU - Chen, Lei
TI - Time-resolved laser speckle contrast imaging (TR-LSCI) of cerebral blood flow response to intracranial pressure elevation
T2 - Journal of biomedical optics
J2 - J Biomed Opt
PY - 2026
DA - 2026/
VL - 31
IS - 8
SP - 086007
SN - 1083-3668
PB - Society of Photo-Optical Instrumentation Engineers
DO - 10.1117/
UR - https://
LA - en
ER -
CSL-JSON
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"author": [
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