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Sound-evoked auditory neurophysiological signals are a window into prodromal functional differences in a preclinical model of Alzheimer's disease.

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Paper

Loaded from Europe PMC by your browser, not stored by OSCR: doi.org · Europe PMC

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The authors' code

Markdown · 16 lines · 1.7 KB · CC-BY-4.0

  1. # Instructions
  2. When creating these scripts, we used Matlab 2021A, with toolboxes listed in instructions.txt at the top level directory in the accompanying zip file.
  3. Scripts are separated by figure numbers, but in some cases, data and functions are shared across folders, so it is not recommended to take subdirectories out of the main directory.
  4. To ameliorate freezing issues on certain platforms (macOS using M1 processors, in our case), we’ve disabled showing the plots by default, and instead, the .TIF files are saved in the directory the scripts are run in.
  5. In the special case of K-means clustering visualizations in figures 10/12 where the results aren’t always deterministic, for the purposes of recreating similar visualizations with matching labels, we opted to continuously run the K-means clustering until the labels were the same as in the paper, rather than dynamically determining the correct labels at runtime. This is strictly for demonstration purposes.
  6. ## Troubleshooting
  7. 1. There is a small chance that there could be small issues in the code, due to the chance that all of the code may not be platform-independent. If there is an issue with the code, please make sure that the path separators are correct on your platform. To compare, on your Matlab installation, you can run ```matlab
  8. yourPath = [‘your’ filesep ‘path’ filesep ‘here’]
  9. ```
  10. and compare that output the path in the code that has the issue. The resulting output on my machine is ‘your/path/here’
  11. 2. The second common error when sharing Matlab code is dreaded PATH errors. We’ve taken every precaution to prevent these from being an issue. When running these scripts, please make sure you’re running them from the directory they belong in.

README.md, under CC-BY-4.0 · at the source

Overview

Authors: Aysegul Gungor Aydin1,2, Pranav Manoj3, Faiza Ramadan4, Sarah Rajan4, Elias Youssef4, Elizabeth B. Torres5,6,7,8, Kasia M. Bieszczad4,7,8
  1. Biomedical Research Institute of New Jersey,Cedar Knolls, NJ 07927 USA
  2. Atlantic Health System,Morristown, NJ 07960 USA
  3. Rutgers Robert Wood Johnson Medical School,New Brunswick, NJ 08901 USA
  4. Department of Psychology—Behavioral and Systems Neuroscience, Rutgers University-New Brunswick,327 Psychology Building, 152 Frelinghuysen Road, Piscataway, NJ 08854 USA
  5. Department of Psychology—Cognitive Psychology, Rutgers University,Piscataway, NJ 08854 USA
  6. Computational Biomedicine Imaging and Modelling, Rutgers University,Piscataway, NJ 08854 USA
  7. Rutgers Center for Cognitive Science (RuCCS), Rutgers University,Piscataway, USA
  8. Department of Head and Neck Surgery & Communication Sciences, Rutgers Robert Wood Johnson Medical School,New Brunswick, NJ 08901 USA
Journal: Scientific reports, volume 16, issue 1, article 23850
Dates: received 15 August 2025; accepted 30 April 2026; published online 9 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41598-026-51854-8 · PMID 42106438 · PMCID PMC13433988 · OpenAlex W4413211054
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: human (organism), rat (organism), Alzheimer's / dementia (population), clinical / translational (subfield)
Methods: Spectral & time-frequency, Statistics, Connectivity, Smoothing, state filtering, decompositions
Keywords: Auditory system, Alzheimer’s disease, Biomarker, Neuroplasticity, Memory, Auditory brainstem response (ABR), Biomarkers, Neurology, Neuroscience
MeSH: Alzheimer Disease*, Evoked Potentials, Auditory, Brain Stem*, Acoustic Stimulation, Amyloid beta-Protein Precursor, Animals, Biomarkers, Disease Models, Animal, Female, Humans, Male, Prodromal Symptoms, Rats, Rats, Transgenic (* major topic)
Topic: Neuroscience and Music Perception (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: Nancy Lurie Marks Family Foundation (Career Continuation Award); National Institute on Deafness and Other Communication Disorders (DC018561); School of Arts & Sciences, Rutgers University-New Brunswick; Busch Biomedical Grant Program, Rutgers University
Citations: not cited yet (Europe PMC); 79 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Repository

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Zenodo 6299560

License: CC-BY-4.0
State: the link answers, verified on 28 September 2026
Evidence: files inventoried
Size: 2 files
Software Heritage: not checked
Found in: “Data availability”
Holds: README
Not found: license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 28 September 2026: the link answers (HTTP 200)
  • 28 September 2026: the link answers (HTTP 200)
1 file

The paper's code and data availability statement is in the Data section.

Tracing map

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  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 0 scripts, each with its path and the digest of its content;
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Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41598-026-51854-8.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 9 keywords, 13 MeSH terms, 4 funders, 78 references.

Cite

This paper

Gungor Aydin, A., Manoj, P., Ramadan, F., Rajan, S., Youssef, E., Torres, E. B., & Bieszczad, K. M. (2026). Sound-evoked auditory neurophysiological signals are a window into prodromal functional differences in a preclinical model of Alzheimer's disease. Scientific reports, 16(1), 23850. https://doi.org/10.1038/s41598-026-51854-8

BibTeX

@article{gungoraydin2026sound,
author = {Gungor Aydin, Aysegul and Manoj, Pranav and Ramadan, Faiza and Rajan, Sarah and Youssef, Elias and Torres, Elizabeth B. and Bieszczad, Kasia M.},
title = {{Sound-evoked auditory neurophysiological signals are a window into prodromal functional differences in a preclinical model of Alzheimer's disease}},
journal = {Scientific reports},
year = {2026},
month = may,
volume = {16},
number = {1},
pages = {23850},
publisher = {Nature Publishing Group},
issn = {2045-2322},
doi = {10.1038/s41598-026-51854-8},
url = {https://doi.org/10.1038/s41598-026-51854-8},
pmid = {42106438},
pmcid = {PMC13433988}
}

RIS

TY - JOUR
AU - Gungor Aydin, Aysegul
AU - Manoj, Pranav
AU - Ramadan, Faiza
AU - Rajan, Sarah
AU - Youssef, Elias
AU - Torres, Elizabeth B.
AU - Bieszczad, Kasia M.
TI - Sound-evoked auditory neurophysiological signals are a window into prodromal functional differences in a preclinical model of Alzheimer's disease
T2 - Scientific reports
J2 - Sci Rep
PY - 2026
DA - 2026/05/09
VL - 16
IS - 1
SP - 23850
SN - 2045-2322
PB - Nature Publishing Group
DO - 10.1038/s41598-026-51854-8
UR - https://doi.org/10.1038/s41598-026-51854-8
LA - en
ER -

CSL-JSON

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The tracing map gets a citation of its own once an author has validated it and it has a DOI.

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