OSCR

Parthenogenote-derived brain unveils the critical role of paternal genome in neural development.

Overview

Authors: Marina Takechi1,2, Yezhang Zhu3, Zezhen Lu3, Ying Zeng4, Ken-ichi Mizutani4, Toru Nakano1, Li Shen3, Shinpei Yamaguchi1,2
  1. Graduate School of Frontier Biosciences, Osaka University, Osaka, 565-0871 Japan
  2. Stem Cells and Reprogramming Laboratory, Department of Biology, Faculty of Science, Toho University, Chiba, 274-8510 Japan
  3. The MOE Key Laboratory of Biosystems Homeostasis and Protection and Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310058 China
  4. Laboratory of Stem Cell Biology, Graduate School of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe, 650-8586 Japan
Institutions: Toho University (Japan); The University of Osaka (Japan); Zhejiang University (China); Kobe Gakuin University (Japan)
Journal: Scientific reports, volume 16, issue 1, article 24021
Dates: received 21 November 2025; accepted 27 May 2026; published online 8 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41598-026-55790-5 · PMID 42260083 · PMCID PMC13439475 · OpenAlex W7163889570
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), developmental (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Evoked potentials
Keywords: Genomic imprinting, Brain development, Neurogenesis, Notch signaling, Cell biology, Developmental biology, Genetics, Neuroscience, Stem cells
MeSH: Brain*, Genomic Imprinting*, Neurogenesis*, Parthenogenesis*, Animals, Calcium-Binding Proteins, Cell Differentiation, Female, Gene Expression Regulation, Developmental, Male, Mice, Neural Stem Cells, Neurodevelopment, Receptors, Notch, Signal Transduction (* major topic)
Topic: Fetal and Pediatric Neurological Disorders (Pediatrics, Perinatology and Child Health, Medicine), according to OpenAlex
Funding: Osaka University (CROSS-BOUNDARY Innovation program); Japan Society for the Promotion of Science (25H02581); Toho University (Toho University Grant for Research Initiative Program (TUGRIP))
Citations: not cited yet (Europe PMC); 53 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1038/s41598-026-55790-5.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 9 keywords, 15 MeSH terms, 3 funders, 49 references.

Cite

This paper

Takechi, M., Zhu, Y., Lu, Z., Zeng, Y., Mizutani, K.-i., Nakano, T., Shen, L., & Yamaguchi, S. (2026). Parthenogenote-derived brain unveils the critical role of paternal genome in neural development. Scientific reports, 16(1), 24021. https://doi.org/10.1038/s41598-026-55790-5

BibTeX

@article{takechi2026parthenogenote,
author = {Takechi, Marina and Zhu, Yezhang and Lu, Zezhen and Zeng, Ying and Mizutani, Ken-ichi and Nakano, Toru and Shen, Li and Yamaguchi, Shinpei},
title = {{Parthenogenote-derived brain unveils the critical role of paternal genome in neural development}},
journal = {Scientific reports},
year = {2026},
month = jun,
volume = {16},
number = {1},
pages = {24021},
publisher = {Nature Publishing Group},
issn = {2045-2322},
doi = {10.1038/s41598-026-55790-5},
url = {https://doi.org/10.1038/s41598-026-55790-5},
pmid = {42260083},
pmcid = {PMC13439475}
}

RIS

TY - JOUR
AU - Takechi, Marina
AU - Zhu, Yezhang
AU - Lu, Zezhen
AU - Zeng, Ying
AU - Mizutani, Ken-ichi
AU - Nakano, Toru
AU - Shen, Li
AU - Yamaguchi, Shinpei
TI - Parthenogenote-derived brain unveils the critical role of paternal genome in neural development
T2 - Scientific reports
J2 - Sci Rep
PY - 2026
DA - 2026/06/08
VL - 16
IS - 1
SP - 24021
SN - 2045-2322
PB - Nature Publishing Group
DO - 10.1038/s41598-026-55790-5
UR - https://doi.org/10.1038/s41598-026-55790-5
LA - en
ER -

CSL-JSON

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"language": "en",
"issued": {
"date-parts": [
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}

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